Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"protein kinase A (PKA)"”.
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Hormone-induced expression of the epithelial sodium channel in human airway cells
… the role of serum / glucocorticoid-inducible protein kinase 1 (SGK1) and protein kinase A (PKA) in the responses of hormone-stimulated H441 human airway cells. Dexamethasone, a synthetic glucocorticoid hormone, is thought to evoke expression of the gene encoding SGK1 and, to become …
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A Mis-Expression Screen Identifies a PKA -Anchoring Protein in Antenna Lobe Development
One of the genes recovered was the Drosophila A Kinase anchoring protein 200 (Akap200). This thesis discusses the further characterization of this gene. Akap200 is a Protein Kinase A (PKA) binding protein with multiple binding sites for other signaling molecules, including Protein Kinase C (PKC), …
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Crosstalk Signaling Between cAMP and mTORC1
… to regulate anabolic and catabolic processes. G-protein-coupled receptors (GPCRs) paired to Gs proteins increase cyclic adenosine 3'5' monophosphate (cAMP) to activate protein kinase A (PKA), which phosphorylates Raptor at Ser 791 resulting in potent mTORC1 inhibition. We identified a novel …
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Towards the full molecular investigation of protein kinase a mediated catalysis by NMR spectroscopy.
The reversible phosphorylation of proteins is fundamental to the modulation of myocardial contraction. A mechanism which controls this modulation occurs through alterations of Ca2+ flux formed across the sarcoplasmic reticulum (SR) membrane inside cardiomyocytes. Changes in this flux have a …
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Angiotensin-(1-9) prevents cardiomyocyte hypertrophy via miR-129-3p/PKIA/PKA signaling pathway
… signaling pathway at a transcription and protein level in a model of norepinephrine-induced cardiomyocyte hypertrophy. To further investigate the anti-hypertrophic mechanism of angiotensin-(1-9), we performed RNA-seq studies, identifying the upregulation of miR-129 under angiotensin-(1-9) …
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Central Role Of CGRP And Protein Kinase A In Promoting Trigeminal Sensitization In An In Vivo Model Of Temporomandibular Joint Disorder
… are mediated by increases in the activity of the protein kinase A (PKA), a protein known to cause neuronal sensitization. In my study, I tested the hypothesis that elevated levels of CGRP in the upper spinal cord promote both central and peripheral sensitization of trigeminal nociceptive neurons. …
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Observing the effects of acetylcholinesterase and brain-derived neurotrophic factor on the levels of soluble amyloid precusor protein α in lung cancer cell media
… to this the levels of soluble amyloid precursor protein α (sAPPα) were higher in H1299 cell media compared to A549 cell media. With these previous findings, we hypothesize that the levels of sAPPα are regulated by AChE and mBDNF. When cells were treated with AChE, sAPPα levels were decreased …
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Adenylyl Cyclase 2 Selectively Regulates IL-6 Expression in Human Bronchial Smooth Muscle Cells
… cellular localization, regulation, and protein interactions, and most cells express multiple isoforms. We hypothesized that cAMP produced by different AC isoforms regulates unique cellular responses. Overexpression of individual isoforms had distinct effects on forskolin (Fsk)-induced …
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Evaluation of Anti-Migraine Drugs in an in Vivo Rat Model of Chronic Migraine
… drugs could inhibit expression of a signaling protein implicated in peripheral and central sensitization. My results provide evidence that the two novel drugs significantly inhibited nocifensive responses and decreased expression of Protein Kinase A (PKA) in the trigeminal ganglion and STN. In …
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Hormonal regulation of phosphodiesterase 3B in adipocytes
… of PDE3B and PDE3B interactions with other proteins. As models to study activation of PDE3B we used primary rat and mouse adipocytes, 3T3-L1 adipocytes and caveolin-1 knock out mouse adipocytes. The study on PDE3B phosphorylation shows that PDE3B is multisite phosphorylated in response to …
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T3-induced hepatocyte proliferation requires β-catenin and is protein kinase A dependent
… Ctnnb1 expression, activity of Glycogen synthase kinase-3β known to phosphorylate and eventually promote β-catenin degradation, or E-cadherin-β-catenin association. However, T3 treatment increased β-catenin phosphorylation at Ser675, an event downstream of protein kinase A (PKA). Administration of …
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Vasopressin kontrolliert die Proteinmenge des Wasserkanals Aquaporin-2 durch Hemmung des proteosomalen Abbaus
… signaling pathway in which the activation of protein kinase A (PKA) by cyclic adenosine monophosphate (cAMP) leads to the phosphorylation of AQP2, e.g., an increase in serine-256 phosphorylation. In addition, AVP causes activation of the transcription factor CRE (cAMP responsive element) and …
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Protein Kinase A Regulates Hyphal Growth by Relieving the Interaction of MoSfl1 with the Cyc8-Tup1 Co-repressor in Magnaporthe oryzae
The cAMP-dependent protein kinase A (PKA) signal transduction pathway plays an important role in morphogenesis and virulence in plant pathogenic fungi. In the rice blast fungus Magnaporthe oryzae, it regulates surface recognition, appressorium turgor generation, and invasive growth. Two genes in M. …
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Epac-mediated modulation of neurotransmitter release from cultured hippocampal neurons
… beeinflusst sekretorische Prozesse sowohl durch Protein Kinase A (PKA)-abhängige als auch durch PKA-unabhängige Signaltransduktionsprozesse. Dennoch ist der jeweilige Anteil an einer cAMP-vermittelten Regulation der Neurotransmission nur unzureichend bekannt. In verschiedenen Preparationen von …
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NDE1 in the DISC1 pathway: interactions of schizophrenia-related proteins
… illness a large Scottish family. The DISC1 protein is believed to act as a molecular scaffold within the cell, binding to a large number of other proteins. Three of these protein interactors, Phosphodiesterase 4B (PDE4B), Nuclear Distribution Factor E (Aspergillus nidulans)-homologue 1 …
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The Development of a Time-Resolved, Vesicle-Based, Fluorescence Assay for the Activity of the Lipid Kinase Pik1
Pik1 is a yeast phosphatidylinositol-4 kinase that is critical for vesicular traffic to the plasma membrane and endosomes from the trans-Golgi (1, 2). Pik1 is a soluble enzyme, and the small myristoylated, Ca2+ binding, EF hand protein, Frequenin (Frq1) facilitates its membrane localization (3). It …
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On the transmission properties of synapses made between granule cells and cerebellar Purkinje cells
… 4-16Hz for 15s. This form of LTP is dependent on protein kinase A (PKA) and nitric oxide (NO), and can spread to distant synapses. Application of an extracellular NO scavenger, cPTIO, was found to prevent the spread of LTP to distant PF synapses in rat cerebellar slices. G-substrate may be an …
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Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
… The effects of cAMP are mediated mainly by protein kinase A (PKA) and the more recently discovered exchange protein directly activated by cAMP (Epac). Epac has two isoforms, the ubiquitously expressed Epac1 and the more tissue restricted Epac2. The biological functions of Epac1 have been …
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Interplay of Brain Derived Neurotrophic Factor and Protein Kinase A in Modulating Mitochondrial Structure and Function in Brain Homeostasis and Disease
… BDNF which binds and activates the Tropomyosin Kinase β (Trkβ) receptor to promote rapid endocytosis and translocation of the signaling endosome to the mitochondria leading to elevated activation of Protein Kinase A (PKA). BDNF-mediated activation of mitochondrial PKA led to an increase in …
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Regulation of IL-6 signal transduction, contributions of the Signal Regulatory Protein (SIRP) and cyclic AMP
The transmembrane glycoprotein “signal regulatory protein/SHP-substrate” (SIRP alpha/SHPS-1) has been implicated in growth factor- and cell adhesion-induced signalling. In the first part of this thesis it is shown for the first time that SIRP alpha contributes to IL-6-type cytokine signalling. SIRP …
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