Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 121 for “"protein kinase A"”.
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Regulation of NeuroD/BETA2 by cAMP Dependent Protein Kinase A Signaling pathway
… PKA에 의한 NeuroD의 인산화 위치는 정제된 NeuroD의 in vitro kinase assay와 Mass spectrometric peptide mapping analysis 방법으로 찾아내었다. 또한 인산화 위치로 알려진 각 아미노산을 돌연변이 시킴으로써 이를 wild type과 비교하여 세포내 기능적 차이를 확인하였다. 그 결과, PKA에 의한 NeuroD S137의 인산화는 NeuroD S274의 ERK매개 인산화를 통해 나타나는Ubiquitination과정을 억제함으로써NeuroD 단백질의 안정성을 …
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Characterisation of cyclic adenosine monophosphate/protein kinase A signalling networks in blood platelets
… with PKA I being identified as a lipid raft protein. Our experimental data suggest that the localization of PKA I to lipid rafts is mediated by interaction with A-kinase anchoring proteins (AKAPs). Additionally, PKA signaling events were reversed when potential PKA type I interactions with …
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T3-induced hepatocyte proliferation requires β-catenin and is protein kinase A dependent
… Ctnnb1 expression, activity of Glycogen synthase kinase-3β known to phosphorylate and eventually promote β-catenin degradation, or E-cadherin-β-catenin association. However, T3 treatment increased β-catenin phosphorylation at Ser675, an event downstream of protein kinase A (PKA). Administration of …
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Towards the full molecular investigation of protein kinase a mediated catalysis by NMR spectroscopy.
The reversible phosphorylation of proteins is fundamental to the modulation of myocardial contraction. A mechanism which controls this modulation occurs through alterations of Ca2+ flux formed across the sarcoplasmic reticulum (SR) membrane inside cardiomyocytes. Changes in this flux have a …
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Protein kinase A-dependent phosphorylation and degradation of CDK8 : implications for yeast filamentous growth
… suggests that Cdk8p is regulated by another kinase, Tpk2p. In vitro kinase assays demonstrate that Tpk2p directly phosphorylates Cdk8p on residue Thr37, leading to the destabilization of Cdk8p after growth for 4 hours in SLAD media. Lack of phosphorylation on Thr37 yields a …
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A Structural Basis for Host Cytoskeletal Disruption and Virulence by Yersinia Protein Kinase A
… III secretion apparatus, to deliver virulence proteins directly into cells. These factors commandeer several signaling pathways, often targeting the Rho family of small GTPases which regulate actin cytoskeletal dynamics. A critical virulence determinant in Yersinia species is the Yersinia …
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Protein Kinase A regulates GATA-3 dependent Activation of IL-5 Gene Expression in T Helper Lymphocytes
… ektopische Expression einer katalytisch aktiven Proteinkinase A (PKA) zwar die Synthese von Th2-typischen Lymphokinen stimulieren, nicht jeder die Expression Th1-typischer Lymphokine inhibieren. Dies bedeutet, dass die Aktivierung von PKA selektiv an der Stimulation der Th2-Lymphokinexpression …
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Status Epilepticus Results in a Duration-Dependent Increased Protein Kinase A Activity in the Rat Pilocarpine Model
… blot analysis showed that alteration of PKA protein expression was not responsible for the increase in PKA activity. These results show that SE has a significant duration-dependent effect on PKA activity. Combined with other cellular changes these findings, could represent a mechanism for the …
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Investigating the regulation of the PCTAIRE-1 protein kinase : a new target of AMP-activated protein kinase and beyond?
PCTK1 is a Cdc2-related protein kinase that is poorly characterised. Several studies have investigated its role and regulation, and have provided some insight into its upstream regulation by PKA/CDK5 phosphorylation. Proposed physiological functions include vesicle trafficking and neurite …
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Interplay of Brain Derived Neurotrophic Factor and Protein Kinase A in Modulating Mitochondrial Structure and Function in Brain Homeostasis and Disease
… BDNF which binds and activates the Tropomyosin Kinase β (Trkβ) receptor to promote rapid endocytosis and translocation of the signaling endosome to the mitochondria leading to elevated activation of Protein Kinase A (PKA). BDNF-mediated activation of mitochondrial PKA led to an increase in …
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Protein Kinase A Regulates Hyphal Growth by Relieving the Interaction of MoSfl1 with the Cyc8-Tup1 Co-repressor in Magnaporthe oryzae
The cAMP-dependent protein kinase A (PKA) signal transduction pathway plays an important role in morphogenesis and virulence in plant pathogenic fungi. In the rice blast fungus Magnaporthe oryzae, it regulates surface recognition, appressorium turgor generation, and invasive growth. Two genes in M. …
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Central Role Of CGRP And Protein Kinase A In Promoting Trigeminal Sensitization In An In Vivo Model Of Temporomandibular Joint Disorder
… are mediated by increases in the activity of the protein kinase A (PKA), a protein known to cause neuronal sensitization. In my study, I tested the hypothesis that elevated levels of CGRP in the upper spinal cord promote both central and peripheral sensitization of trigeminal nociceptive neurons. …
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Angiotensin-(1-9) prevents cardiomyocyte hypertrophy via miR-129-3p/PKIA/PKA signaling pathway
… signaling pathway at a transcription and protein level in a model of norepinephrine-induced cardiomyocyte hypertrophy. To further investigate the anti-hypertrophic mechanism of angiotensin-(1-9), we performed RNA-seq studies, identifying the upregulation of miR-129 under angiotensin-(1-9) …
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Hormone-induced expression of the epithelial sodium channel in human airway cells
… the role of serum / glucocorticoid-inducible protein kinase 1 (SGK1) and protein kinase A (PKA) in the responses of hormone-stimulated H441 human airway cells. Dexamethasone, a synthetic glucocorticoid hormone, is thought to evoke expression of the gene encoding SGK1 and, to become …
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A Mis-Expression Screen Identifies a PKA -Anchoring Protein in Antenna Lobe Development
One of the genes recovered was the Drosophila A Kinase anchoring protein 200 (Akap200). This thesis discusses the further characterization of this gene. Akap200 is a Protein Kinase A (PKA) binding protein with multiple binding sites for other signaling molecules, including Protein Kinase C (PKC), …
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Crosstalk Signaling Between cAMP and mTORC1
… to regulate anabolic and catabolic processes. G-protein-coupled receptors (GPCRs) paired to Gs proteins increase cyclic adenosine 3'5' monophosphate (cAMP) to activate protein kinase A (PKA), which phosphorylates Raptor at Ser 791 resulting in potent mTORC1 inhibition. We identified a novel …
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Regulation of duodenal mucosal bicarbonate secretion
… enterocytes, activating adenylate cyclase and protein kinase A in sequence to initiate bicarbonate secretion. In addition, there is good evidence that the inositol phospholipid and protein kinase C cascade is also involved, possibly to a lesser extent, since tetradecanoyl-phorbolacetate and …
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