Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 453 for “"protein interaction"”.
-
Protein-Protein Interaction Network Alignment
Proteins are some of the building blocks of organisms. They usually perform their functions by interacting with each other and forming protein complexes. A protein -protein interaction network is a graph that consists of proteins as vertices and their interactions as edges. Protein-protein …
-
Human protein-protein interaction prediction
Protein-protein interactions are essential for the survival of all living cells, allowing for processes such as cell signalling, metabolism and cell division to occur. Yet in humans there are only >38k annotated interactions of an interactome estimated to range between 150k to 600k interactions and …
-
Localized methods for protein interaction prediction
Identification of protein-protein interactions is important for drug design and the treatment of diseases. We propose a novel threading algorithm, LTHREADER, which generates accurate local sequence-structure alignments and integrates various statistical scores and experimental binding data to …
-
Identifying Evolutionarily Conserved Protein Interaction Networks
Our goal is to investigate protein networks conserved between different organisms. Given the protein interaction networks for two species and a list of homologous pairs of protein in the two species, we propose a model for measuring whether two subnetworks, one in each protein interaction network, …
-
Targeting the p53/MDM2 protein-protein interaction
The p53/MDM2 protein-protein interaction is the most widely characterised proteinprotein interaction to date. As of 2014, there are over 20 compounds that have been shown to the p53-MDM2 protein-protein interaction, however many compounds have not progressed into clinical trials due to their high …
-
Tear protein interaction with hydrogel contact lenses
… environment in which it is used. Adsorption of proteins takes place almost instantaneously when a biomaterial comes into contact with most biological fluids. The eye is a unique body site for the study of protein interactions with biomaterials, because of its ease of access and deceptive …
-
Statistical analysis of protein interaction network topology
… of such systems. In this work we investigate the protein-protein interaction network of the KSHV herpesvirus, which is the first viral system available, and compare it to a prototypical cellular system. On the local level, we investigated the relationship between interaction and sequence …
-
Towards a comprehensive human protein-protein interaction network
Obtaining a reliable interaction data set describing the human interactome is a milestone yet to be reached. The past few years has seen tremendous progress in elucidating the yeast interactome. Experimental approaches for obtaining large-scale protein interaction data coupled with powerful …
-
Algorithms for the analysis of protein interaction networks
… of systems biology: the understanding of protein interactions. Such understanding is valuable: interactions between proteins are fundamental to many cellular processes. Over the last decade, high-throughput experimental techniques have allowed us to collect a large amount of …
-
The genetic landscape of protein-protein interaction specificity
Protein-protein interaction specificity is often encoded at the primary sequence level, and by just a few interfacial residues. Collectively, these residues have both positive and negative roles, promoting a desired, cognate interaction and preventing non-cognate interactions, respectively. …
-
Structure-based algorithms for protein-protein interaction prediction
Protein-protein interactions (PPIs) play a central role in all biological processes. Akin to the complete sequencing of genomes, complete descriptions of interactomes is a fundamental step towards a deeper understanding of biological processes, and has a vast potential to impact systems biology, …
-
Expanding the Spiroligomers Toolbox as Protein-Protein Interaction Inhibitors
… application of spiroligomers as inhibitors of protein-protein interactions. After the discovery of an acyl-transfer coupling reaction by Dr. Zachary Brown, a previous graduate student of Schafmeister group, the synthesis of highly functionalized spiroligomers that mimic the helical domain of …
-
Investigation of protein-protein interaction using atomic force microscopy
… approaches to measuring the kinetics of protein dissociation have the advantage that measurements can be performed in native environments, such as living cells, where concentrations of target molecules may be quite low. In addition, single molecule approaches allow for the measurement of …
-
Substrate-Protein Interaction in Tryptophanase Purified From Bacillus Alvei
Made available in DSpace on 2014-12-11T18:16:53Z (GMT). No. of bitstreams: 1 7405565.pdf: 8246734 bytes, checksum: 3f00bf52bb63d089cb1074dddafc0f8d (MD5) Previous issue date: 1973
-
On the structure and evolution of protein interaction networks
The study of protein interactions from the networks point of view has yielded new insights into systems biology [Bar03, MA03, RSM+02, WS98]. In particular, "network motifs" become apparent as a useful and systematic tool for describing and exploring networks [BP06, MKFV06, MSOI+02, SOMMA02, SV06]. …
-
A Study on the Protein Interaction with Different Platinum Compounds
… histidine and cysteine to form cisplatin-protein adducts which are responsible for most of its cytotoxicity and side effects. Recent articles on cisplatin-protein have shown that adding bulky adjuncts to cisplatin or using different platinum compounds varies the degree and extent of …
-
Design and Synthesis of Small-Molecule Protein-Protein Interaction Antagonists
Protein-protein interactions play a crucial role in a wide range of biological processes. Research on the design and synthesis of small molecules to modulate these proteinprotein interactions can lead to new targets and drugs to modulate their function. In Chapter one, we discuss the design and …
-
Structurally Motivated Deep Learning for Genome Scale Protein Interaction Prediction
Protein-protein interaction (PPI) networks have proven to be a valuable tool in systems biology to facilitate the discovery and understanding of protein function. However, experimental PPI data remains sparse in most model organisms and even more so in other species. Existing methods for …
-
Parameter Identifiability and Estimation in Gene and Protein Interaction Networks
… with respect to different measurements (proteins and mRNA), and propose a working definition for "biologically meaningful estimation". We also analyze the correlations between parameters, and use this analysis to consider effective approaches to determining parameters with biological …
-
Network to pology In Human Protein Interaction Data Predicts Functional Association
… system, have generated a huge amount of protein-protein interaction (PPI) data in the past decade. This tremendously increases the need for developing reliable methods to systematically and automatically suggest protein functions and relationships between them. With the available PPI …
Page 1 of 23