Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 73 for “"protein homeostasis"”.
-
Circadian Regulation of Protein Homeostasis
… processes. In various models, rhythms in protein abundance of 10-20% of the proteome have been reported. However, regulation of these rhythms is not well understood, as most of them are not accounted for at the transcript or even ribosomal occupancy level. It is also unclear how circadian …
-
Geroprotective and antineoplastic functions of protein homeostasis
La homeostasis proteica, o proteostasis, comprende una compleja red molecular encargada de mantener la estabilidad del proteoma, controlando la conformación, localización y concentración de proteínas dentro de las células. Su alteración afecta al correcto funcionamiento de las células y está …
-
Leveraging Protein Homeostasis as a Disease-modifying Strategy
Protein homeostasis (proteostasis) is a fundamental determinant of cellular health, and its impairment is causally linked to a wide range of human diseases. While extensive eHort has gone into characterising how the proteostasis network (PN) maintains proteins in their functional states, more work …
-
Transcriptomic studies of protein homeostasis perturbations in neurodegenerative disorders
… disorders associated with the aggregation of tau protein, which is a hallmark of AD and other diseases, in order to underline the importance of the balance between key molecular mechanisms in combatting the disease progression. The endpoint of this work is a unified picture of the biological …
-
Probing the protein homeostasis mechanisms in long-lived naked mole-rats
… diseases. Recent evidence suggests that protein homeostasis (proteostasis) mechanisms may play a vital role in mediating the resistance to multiple forms of stress and diseases and, subsequently, contribute to the exceptional longevity of the NMR. However, this view has been predominately …
-
Proteomics studies of protein homeostasis and aggregation in ageing and neurodegeneration
Upon ageing, a progressive disruption of protein homeostasis often leads to extensive protein aggregation and neurodegeneration. It is therefore important to study at the proteome level the origins and consequences of such disruption, which so far have remained elusive. Addressing this problem has …
-
TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
… particularly sensitive to perturbations in ion homeostasis, especially when ion gradients are perturbed in combination with MAP kinase inhibition. I hypothesized that melanoma cells preferentially require certain ion channels and transporters for growth and survival. I thus screened ion channels …
-
THE ARABIDOPSIS THALIANA ABC TRANSPORTERS TAP1, NAP8 AND ATH12 EXTRUDE PEPTIDES FROM CHLOROPLASTS AND ARE LINKED TO CHLOROPLAST PROTEIN HOMEOSTASIS MAINTENANCE.
… possiede un genoma che ancora esprime poche proteine plastidiali. Come diretta conseguenza, il proteoma del cloroplasto è un mosaico di proteine codificate dal nucleo e dal cloroplasto stesso. Questo richiede un importante scambio di informazioni tra i due genomi, per coordinare …
-
SURVIVING UNDER PRESSURE: TRANSLATIONAL REWIRING IN RESPONSE TO MECHANICAL STIMULI
… cellular density. Both cell size and density homeostasis are integral features of healthy tissues, intricately linked to the regulation of the cell cycle and biosynthesis processes. This connection suggested that achieving density homeostasis could involve a coupling mechanism between the …
-
Characterization of the Molecular Mechanisms of Xenobiotic-Induced NRF2 Activation for Disease Prevention and Intervention
… expression of genes involved in drug metabolism, protein homeostasis, anabolic metabolism, inflammation, proliferation, and survival. Understanding the molecular mechanisms of xenobiotic-induced NRF2 activation is crucial to guiding treatments for disease prevention and intervention. On the one …
-
Analysis of The Biochemical and Cellular Activities of Substrate Binding By The Molecular Chaperone Hsp110/Sse1
<p>Molecular chaperones ensure protein quality during protein synthesis, delivery, damage repair, and degradation. The ubiquitous and highly conserved molecular chaperone 70-kDa heat-shock proteins (Hsp70s) are essential in maintaining protein homeostasis by cycling through high and low affinity …
-
Molecular origins of tissue vulnerability to aberrant aggregation in protein misfolding diseases
… clear that, although the aggregation of specific proteins, including amyloid β (Aβ) and tau in AD and α-synuclein in PD, hallmark these disorders, such behaviour is a consequence of a wider, system-level disruption of protein homeostasis. In order to identify the genetic factors contributing to …
-
Overexpression of Heat Shock Factor 1 Protects against Pathological Proteins in Neurodegenerative Diseases
… disorders is the accumulation of protein aggregates, such as TAR DNA/RNA binding protein (TDP-43) and superoxide dismutase 1 (SOD1), which lead to neuronal dysfunction and loss. Therefore, molecules that maintain protein homeostasis may be beneficial therapeutic targets to correct …
-
Functional Analysis of Cytosolic Hsp70 Nucleotide Exchange Factor Networks In Yeast
… of molecular chaperones play critical roles in protein homeostasis via an ATP-dependent folding cycle. Cytosolic Hsp70s in the budding yeast <em>Saccharomyces cerevisiae, </em>Ssa and Ssb, interact with up to three distinct nucleotide exchange factors (NEFs) homologous to human counterparts; …
-
The Role of ATF5 in Mitochondrial Maintenance, Biogenesis and UPRmt Signaling Following Acute Exercise in Skeletal Muscle
Maintenance of the mitochondrial protein folding environment is essential for organellar and cellular homeostasis. The Mitochondrial Unfolded Protein Response (UPRmt) is a protein quality control mechanism that relieves intraorganellar proteotoxic stress in a manner dependent on activating …
-
Defect of Mitochondrial Translation Machinery Enhances Hepatoma Cell Invasiveness
… in SNU hepatoma cells. 10 2. Mitochondrial protein homeostasis is associated with mitochondrial dysfunction. 12 3. Mitochondrial translation machinery defect may be a key event in mitochondrial dysfunction in hepatoma cells 14 4. Mt-TMD-related invasive behavior induced by doxycycline in …
-
Unveiling the Intercompartmental Signaling Axis: Mitochondrial to ER Stress Response (MERSR) and Its Impact on Proteostasis
<p>Maintaining protein homeostasis is essential for cellular health. During times of protein stress, cells deploy unique defense mechanisms to achieve resolution. Our previous research uncovered a cross-compartmental Mitochondrial to Cytosolic Stress Response (MCSR), a unique stress response …
-
Statistical methods to infer biological interactions
… classes of important biological interactions: protein-protein interactions and the link between genotypes and phenotypes. In the first part of the thesis, we introduce methods to infer protein-protein interactions from affinity purification mass spectrometry (AP-MS) and from luminescence-based …
-
Investigating the protein targets of the neuroprotective E3 ligase, CHIP
Identifying early defects in protein homeostasis (“proteostasis”) in neurodegeneration could shed light into disease-promoting events and provide promising therapeutic targets for disease modification. A key player in the regulation of proteostasis is the dual function chaperone and E3 ligase …
-
Hsp70-Mediated Regulation of Hsf1 Transcriptional Activity In Saccharomyces Cerevisiae
<p>In eukaryotic cells, protein homeostasis and cellular fitness is promoted by the transcription factor heat shock factor 1 (HSF1) during exposure to proteotoxic stress. HSF1 controls the basal and stress-induced expression of molecular chaperones and other protective targets. Dynamic regulation …
Page 1 of 4