Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"protein formulation"”.
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Upgrading the Protein Formulation Toolbox through Predictive and Explanatory Models
Native proteins are metastable molecules; slight perturbations in environmental conditions— temperature, moisture, pH, etc.— can quickly (and often irreversibly) degrade these biological structures. The implications of this instability are directly related to a myriad of diseases, biologic …
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Functional characterization of pH and ultrasound treated soy protein based nanoemulsions with lutein
… this research, a pH and ultrasound treated soy protein isolate was used as emulsifier to create nanoemulsions with lutein. Two types of nanoemulsions were successfully created with 10 mg/ml soy protein and 0.054 mg/ml lutein. One contained 0.25% oil and was homogenized with ultrasound (SEO); and …
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Modulation of Endothelial Cell Adhesion to Synthetic Vascular Grafts Using Biotinylated Fibronectin in a Dual Ligand Protein System
… cell seeding onto the sequentially adsorbed protein surface was examined as a function of surface immobilized protein and Trypsin/EDTA concentration. SPR results showed statistical differences in α5β1 and αvβ3 integrin binding to RGD cell binding motifs introduced by bFN(9) and RGD-SA. …
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Mass Spectrometry-Based Strategies for Biomolecular Structure Analysis: Steroid Metabolites Structures and Protein-Protein Interactions
… small molecules and large biomolecules (e.g., proteins). The majority of the applications prior to 1970 were focused on small molecules, owing to the limited ionization methods which posed difficulties in producing gas-phase ions for large biomolecules then. Beginning in the 1980's, with the …
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Application of fluorescence spectroscopy for the in-vial investigation of protein solutions
Therapeutic protein formulations are subjected to various stressors during manufacturing, transport, and storage, causing destabilisation, in turn leading to deleterious effects such as immunogenic reactions or inefficacy upon administration. An essential part of this production and supply process …
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Molecular Dynamics Simulations to Enhance Stability in Biopharmaceutical Formulations - A Focus on Cyclodextrins and Interfaces
L'abstract è presente nell'allegato / the abstract is in the attachment