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Showing 1 to 4 of 4 for “"protein fatty acylation"”.
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Develoment and Application of Chemical Strategies to Study Protein Fatty-Acylation in Eukaryotes
… confers spatiotemporal control of protein function by modulating protein stability, trafficking and activity as well as protein-protein and membrane-protein associations. While it is evident that palmitoylation is regulated in vivo, mechanisms that mediate cellular stimuli-driven …
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METABOLISM-COUPLED PROTEIN POST-TRANSLATIONAL MODIFICATIONS IN C. ELEGANS AND MAMMALIAN MODELS
… which often rely on metabolic feedback on protein function, for example, by way of product inhibition of enzymes and protein post-translational modifications (PTMs). PTMs are chemical modifications that occur on proteins after their synthesis, enabling rapid and often reversible functional …
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DHHC PROTEIN ACYLTRANSFERASES CATALYZES THE LYSINE PALMITOYLATION OF MEMBERS OF THE RAS SUPERFAMILY OF SMALL GTPASES
Protein fatty acylation is the attachment of a long-chain fatty acyl group, generally 14–16 carbons in length to the side chain of an amino acid. Cysteine palmitoylation or S-palmitoylation is best understood and widespread post-translational modification in this class, followed closely by …
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Enzymology of DHHC-mediated Protein S-Acylation
Protein <italic>S</italic>-acylation is the post-translational modification of proteins with long-chain fatty acids at cysteine residues via a thioester linkage. The most commonly attached lipid is 16-carbon palmitate, thus the process is often called palmitoylation. Unlike other lipid …