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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"protein dynamics"”.
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Solvent viscosity and protein dynamics
Submitted by Carolyn Mead (cmead2@illinois.edu) on 2011-06-16T16:14:28Z No. of bitstreams: 1 1981_marden.pdf: 2229185 bytes, checksum: e08cab5b997b888be1fc137c39869f7c (MD5)
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Ligand and Protein Dynamics of CYP3A4
… of the linkage between ligand binding and protein conformational dynamics with theoretical considerations of their impact on CYP3A4 catalysis using biophysical and theoretical methodologies. Specifically, the results herein demonstrate the complexity (requiring more than 2-states) in the …
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Single-molecule imaging studies of protein dynamics
… focuses on single molecule studies of the dynamics of Green Fluorescent Protein: GFP) and other fluorescent-labeled proteins by utilizing Total Internal Reflection Fluorescence: TIRF) microscopy and imaging. The single molecule experiments of this thesis covered three broad topics. First, …
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Crystalline Protein Dynamics : A Simulation Analysis of Staphylococcal Nuclease
Understanding motions in protein crystals is likely to furnish insight into functional protein dynamics and will improve models for refinement against diffraction data. In this thesis, molecular dynamics (MD) simulations of crystalline Staphylococcal nuclease are reported and analysed in terms of …
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Coarse-grained Modeling of Protein Dynamics using Elastic Network Models
Dynamics is crucial for the functioning of biological macromolecules. Because of severe limitations in studying protein dynamics experimentally or with all-atom simulations, coarse-grained methods, especially elastic network models (ENMs), are frequently employed. In the last years, studies on …
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Protein Dynamics and its Correlation to Protein Activity and Stability
… this thesis is to investigate the role of fast protein dynamics (picosecond timescale) in enzyme activity and stability, and specifically to test the hypothesis that enzyme activity and stability are inversely related by their internal dynamics. Activity Dynamics (flexibility) 1/Stability In …
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Temperature- and pressure-induced protein dynamics from microseconds to minutes
For the past two decades, protein folding experiments have been speeding up from the second or millisecond time scale to the microsecond time scale, and full-atom simulations have been extended from the nanosecond to the microsecond and even millisecond time scale. Where the two meet, it is now …
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NMR Studies on Protein Dynamics and Its Relevance to Functional Kinetics.
Existence of a strong relationship between protein's dynamics and its functional kinetics was suggested decades ago. Even though different groups investigated this relationship, technical difficulties and lack of appropriate methodology make full understanding of this relationship quite …
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Protein Dynamics : Comparison of Incoherent Neutron Scattering and Molecular Dynamics Simulation
Proteindynamik und deren Beziehung zur biologischen Funktion von Proteinen ist Gegenstand zahlreicher experimenteller und theoretischer Untersuchungen. In der vorgelegten Arbeit werden Aspekte der Proteindynamik im Pico- und Nanosekundenbereich untersucht. Experimentelle Untersuchungen haben eine …
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Computational investigations of protein dynamics and its implications for biological functions
… simulation is a powerful approach to study protein dynamics and functions. We employed molecular dynamics (MD) simulations to investigate large conformational changes in proteins, including folding, dimerization, and unfolding, and how these conformational changes help the proteins perform …
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Membrane and membrane protein dynamics studied with time-resolved infrared spectroscopy
Proteins are the machinery of the cell, performing functions essential for life. Proteins do not operate in isolation, however. Their function is intimately coupled to their environment; changes in this environment modulate the behavior of the protein. One of the most striking examples of …
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Probing biology on its home turf: Tools for ethology and protein dynamics
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Computational methods to design biophysical experiments for the study of protein dynamics
… and data acquisition. In the field of protein biophysics, computational simulations such as molecular dynamics and spectroscopy-based experiments such as double electron-electron resonance and Fluorescence resonance energy transfer techniques have emerged as critical experimental tools …
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Dissecting nuclear protein dynamics and structural changes with single-molecule spectroscopy and microscopy
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-08-01
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Pigment-Pigment Interactions and Protein Dynamics in Light-Harvesting Complexes: a Single-Molecule Study
… to monitor conformational fluctuations of the protein residues in their binding pocket. Looking at the spectral diffusion of individual chromophores allowed to elucidate the organisation of the protein-energy landscape in tiers. In addition a clear correlation for the transition rates between …
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Properties of immunoglobulin Fv domains: Influence of valence and protein dynamics on antibody/antigen interactions
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by Howard Ding (hding2@illinois.edu) on 2011-05-07T14:44:43Z Item is restricted indefinitely.
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Enabling tools for biological analysis : technologies for the study of protein dynamics, detection and interaction
The study of proteins in biological systems requires a comprehensive approach: investigating dynamics, interaction and identification. This thesis will examine several technological approaches we have developed to address these needs. To enable the study of the dynamics of biological systems, we …
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Biophysical Investigation into the Protein Dynamics Governing the Allosteric Regulation of Plant and Animal 15-Lipoxygenases
… driven. We also employed HDX-MS to study the dynamics of 15-LOX-1 compared to previously collected data of 15-LOX-2 to reveal structural differences between the two isozymes that may explain their altered catalytic behavior.
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Spectroscopic Studies of Protein Folding and Protein Dynamics Using Single-Tryptophan Mutants of E. Coli Adenylate Kinase
"An ""atlas"" of the various equilibrium states of E. coli adenylate kinase is presented in the final summary chapter."
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