Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"protein disaggregation"”.
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Investigating the protein disaggregation machinery in the early secretory pathway
Protein misfolding and subsequent aggregation represent key pathological features in various forms of dementia, notably Alzheimer’s disease (AD). AD is characterised by the presence of extracellular plaques, comprised of aggregated amyloid beta (Aβ) peptides, and intracellular neurofibrillary …
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Investigation of the role of HSP70 in the uptake of Granzyme B by Malaria parasite-infected erythrocytes
… changes, resulting in upregulation of heat shock proteins (Hsps). These Hsps facilitate protein folding and protein disaggregation. Hsp70 is a molecular chaperone whose function is to facilitate protein folding. P. falciparum Hsp70-x is the only member of this family of proteins that is exported …
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Functional Analysis of Cytosolic Hsp70 Nucleotide Exchange Factor Networks In Yeast
… of molecular chaperones play critical roles in protein homeostasis via an ATP-dependent folding cycle. Cytosolic Hsp70s in the budding yeast <em>Saccharomyces cerevisiae, </em>Ssa and Ssb, interact with up to three distinct nucleotide exchange factors (NEFs) homologous to human counterparts; …
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Untersuchungen zur Struktur und Substratspezifität des AAA+-Chaperons ClpB in Escherichia coli
… und inhibiert die ClpB-vermittelte Auflösung von Proteinaggregaten. <br>(2) Poly-L-Lysin ist kein Substrat von ClpB, sondern ein Effektor, der durch Stimulation der ATPase-Aktivität die Disaggregationsaktivität von ClpB erhöht. <br>(3) Peptide, die als ClpB-Binder in Peptidbibliotheken …