Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"protein dimerization"”.
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Development of a human plasmacytoma cell line with inducible expression of activated B-cell factor-1
<p>The basic helix-loop-helix protein, activated B-cell factor-l (ABF-l), is a transcription factor involved in cellular proliferation and differentiation. ABF-1 shows patterns of expression that are stimulated in activated B cells, which may suggest ABF-1 is involved in the regulation of B-cell …
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Biochemical Evaluation of SRH Analogs as Potential LuxS Inhibitors
… of LuxS inhibitors that function by preventing protein dimerization. This assay requires that purified LuxS be conjugated with an appropriate fluorophore, likely via a cysteine residue. An appropriate LuxS variant i.e. LuxS Y71C to which a single fluorophore would attach was acquired after …
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The characterization of the ABF-1 promoter
… family oftranscription factors consists of proteins involved in cellular proliferation and differentiation. The HLH structure plays a key role in protein-protein dimerization and with the DNA target sites, referred to as E boxes containing the consensus DNA sequence CANNTG. One class of …
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Statistical Design And Imaging Of Position-Encoded 3D Microarrays
… identification. Here targets: such as mRNAs, proteins, antibodies, and cells) are captured by the microspheres on one side, and are tagged by nanospheres embedded with quantum-dots: QDs) on the other. We use the lights emitted by these QDs to quantify the target concentrations. The imaging is …
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Fret Studies of DNA Binding By Lambda Cro Variants
Proteins bind to DNA to form switches and circuits that control the flow of genetic information from DNA sequence to the physical components of cells and organisms. The dynamic performance of genetic switches depends on the coupling of the comprocesses of transcription and translation to …
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Identification and characterization of gene and microRNA networks associated with cancer survival and drug abuse
… signaling pathway and the molecular functions of protein dimerization and leucine zipper transcription factor were enriched in response to acute exposure. This study was able to detect the progression of drug exposure pathways using meta, functional, and network analyses.
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DNA Recognition by Helix-Loop-Helix Proteins
… factors comprises a large number of proteins which play key roles in homeostasis, the regulation cell proliferation, and differentiation. These proteins share a phylogenetically conserved bipartite b/HLH domain responsible for specific DNA binding and dimerization. The HLH region …