Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"protein biogenesis"”.
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Mechanisms of multipass membrane protein biogenesis
… All these processes require integral membrane proteins (IMPs), which are embedded within all cellular membranes. Highlighting their importance is a myriad of human diseases observed upon disruption of their biogenesis. This thesis aims to describe our recent contributions to the understanding …
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Studies on the mechanisms that contribute to the endoplasmic reticulum quality control system in Saccharomyces cerevisiae
… Reticulum (ER), which serves as a site for protein biogenesis in budding yeast, contains a quality control system that ensures that only proteins that have attained a native conformation are deployed to other destinations in the cell. In order to gain insight into the mechanisms that …
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Uncovering the biogenesis pathways for human mitochondrial alpha-helical outer membrane proteins using genome-wide approaches
… membrane (OMM) contains ~110 different proteins which are encoded in the nuclear genome, synthesized in the cytosol and must be targeted to the membrane. OMM proteins are defined by the secondary structure of their transmembrane domains (TMDs), as two classes – beta-barrel proteins, …
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Characterization of Host Factors and Anti-viral Compounds for Diverse Mosquito-borne Flaviviruses
… with published literature, implicated a larger protein, the ER Membrane Protein Complex (EMC), as a pan-flavivirus HDF. The EMC is a poorly characterized multiprotein complex that may function in ER-associated protein biogenesis and/or lipid metabolism. Based on our screen data, we hypothesized …
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Biogenesis of Multipass Membrane Proteins
… of all genes code for integral membrane proteins. Most membrane proteins pass back and forth across the lipid bilayer multiple times. Multipass membrane proteins, such as ion channels and receptors, are essential for nearly all transport and communication across the plasma membrane. In …
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Organization of the Streptococcal ExPortal and its Interaction with Cationic Antimicrobial Peptides
… are highly dependent on secreted virulence proteins for their ability to colonize a host and evade the immune effectors that act on pathogens to prevent this. Unlike eukaryotes and Gram-negative bacteria, all Gram-positive pathogens lack a cellular compartment dedicated to folding and …
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A role for a predicted E. coli inner membrane lipoprotein in cell envelope integrity
… is composed of phospholipids, glycolipids, and proteins. A large portion of the bacterial cellular proteome is composed of membrane proteins. Despite this, the functions of several membrane proteins are as yet undefined. Therefore, defining the physiological roles of uncharacterized membrane …
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Energetics of [alpha]-helix formation in peptides and proteins
… energetics of !-helix formation in peptides and proteins. The [alpha]-helix is the most prevalent type of secondary structure found in proteins, and has arguably dominated our thinking about protein structure since its discovery, as it plays an important role in the early stages of protein …
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Protein quality control in the mammalian endoplasmic reticulum
Quality control is an important part of protein biogenesis. Aberrant proteins must be destroyed before they aggregate and cause deleterious effects. Failure to do so can result in cell death or malfunction and, ultimately, disease. Quality control involves the recognition of misfolded proteins and …
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Mechanisms Of Presynaptic CaV2 Calcium Channel Localization In Caenorhabditis Elegans
… in vivo assay system to monitor calcium channel biogenesis in intact animals. In my thesis, I established an in vivo system to visualize the UNC-2 alpha1 subunit of the C. elegans CaV2 channel. I showed that GFP-tagged UNC-2 is localized to presynaptic active zones of sensory and motor neurons. …
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Structural Studies of Protein Transport
Most new proteins are made in the cytosol and then targeted to their mature destinations. In the case of integral membrane proteins (IMPs), this targeting concludes with integration into the target membrane, a process typically facilitated by protein-conducting channels. This thesis examines the …