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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 262 for “"protein binding"”.
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Protein binding of vitamin B12
Thesis (M.S.)--Michigan State University. Dept. of Food Science, 1967
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Confirmation of Emx2 Protein Binding Partners
… the molecular mechanisms that involve these proteins. An important step in this process is identifying proteins that bind these various transcription factors. The goal of this project was to confirm protein binding partners for the neocortical transcription factor Emx2, which were previously …
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Plasma protein binding of vitamin B₁₂
[Typescript]; 239 leaves
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Deciphering protein binding specificity with deep learning
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Novel pharmacophore clustering methods for protein binding site comparison
Proteins perform diverse functions within cells. Some of the functions depend on the protein being involved in a protein complex, interacting with other proteins or with other entities (ligands) through specific binding sites on their surface. Comparison of protein binding sites has potential …
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Computational methods for the structure-based design of protein-binding peptides
… de novo design of peptides that bind to target proteins could enable binding to specific epitopes, inhibition of natural interactions, and targeted degradation of proteins. Despite advances in protein engineering, this remains a challenging task due to the large space of peptide structures and …
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Identification of Protein-Phosphate Contacts in the R17 Coat Protein Binding Site
Small RNAs of defined length and sequence can be synthesized enzymatically using T7 RNA polymerase and synthetic DNA templates which contain the T7 promoter. The templates are base paired from $-17$ to +1 and contain a long 5$\sp\prime$ overhang. The products of the transcription reactions have the …
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IN-VITRO METABOLISM AND PROTEIN BINDING OF 5-HMF, A POTENTIAL ANTISICKLING AGENT
… in-vitro studies were done to characterize 5-HMF binding kinetics with human Hb and albumin (HSA). Methods. NAD+ reduction was monitored at 340 nm in human hepatic cytosol for 5-HMF (26 mM) and prototypical ADH and ALDH substrates in the presence or absence of their inhibitors. Furthermore, …
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Proteins on the edge : transitions of structure ensembles in protein unfolding and protein-protein binding
Proteins move. Their incessant fluctuations are governed by a complex interplay between thousands of atoms. Experimental structures, providing exact coordinates for every atom, hence only represent the average of a diverse ensemble of interchanging conformations. Molecular motion is often the …
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Platinum-modified DNA : solution structure and protein-binding preferences of 1,2-intrastrand d(GpG) adducts
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.
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Effects of a putative Reb1 protein binding site on IME4 sense and antisense transcription and sporulation in Saccharomyces cerevisiae
… are currently unknown. The a1-alpha2 heterodimer binding in the downstream 3' region of IME4 is one component required for repression of IME4 antisense transcription. However, this thesis shows that the general regulatory protein Reb1 is also required in this system. Reb1 involvement is most …
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Scanning Probe Investigations of Magnetic Nanoparticles, Protein Binding and the Synthesis of Rare Earth Oxide Nanoparticles Using Nanoscale Lithography
… studies of the chemical steps for patterning proteins are critical for the integration of biomolecules into miniature biological-electronic devices for protein sensing. Rare earth oxide (REO) nanomaterials have useful properties such as upconversion, catalysis, and magnetism. For commercial …
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Molecular interactions in pharmaceutical preformulation and supramolecular complexes. Structural properties governing drug-plasma protein binding and investigation of amino acids co-crystals
… in the formulation. The study of drug-Plasma Protein Binding (PPB), and the lipophilicity, solubility, and ionic behaviours of the desired drug molecules addresses the gap and enhances our undertraining related to the behaviour of the drug molecules in the body. The High-Performance Liquid …
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A structural classification of protein-protein interactions for detection of convergently evolved motifs and for prediction of protein binding sites on sequence level
… era of Bioinformatics is the prediction of protein-protein interactions, and ultimately the prediction of protein functions. The problem is intrinsically harder, when only amino acid sequences are available, but a solution is more universally applicable. So far, the problem of uncovering …
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The Influence of ampC Expression and Penicillin Binding Protein Binding on the Variation of ß-lactam Induction Potential in Three Genera of Enterobacteriaceae
… The interaction of ß-lactams with penicillin binding proteins (PBPs) disrupts cell wall synthesis and in the case of some ß-lactams, initiates the ampC induction pathway. Several factors are involved in the induction of ampC in all genera including the interaction of a ß-lactam inducer with …
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Evaluation of the Pharmacokinetic-Pharmacodynamic relationship, Metabolism and Plasma Protein Binding of the novel antitumor agent, 2-Methoxyestradiol (2ME2), following oral administration in patients with solid tumors.
… will exhibit linear pharmacokinetics; 3) Plasma protein binding will be extensive and linear; 4) Sulfation will be the major metabolic pathway for 2ME2.This was a phase I dose escalation study. Twenty patients with refractory solid tumors were enrolled. 2ME2 was administered orally starting at …
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