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Showing 1 to 5 of 5 for “"protein arginine deiminase"”.
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Kinetic Characterization of the Protein Arginine Deiminase Family: Mechanistic and Inhibition Studies
<p>The family of Protein Arginine Deiminases (PADs) include five mammalian isozymes (PAD1, 2, 3, 4, and 6) that catalyze the post-traslational modification of peptidyl-arginine to peptidyl-citrulline in numerous protein substrates. This modification results in numerous physiological and …
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Unlocking thePadlock: Elucidation of Protein Arginine Deiminase 4 Function, Activity and Activation Dynamics
The Protein Arginine Deiminase (PAD) family contains five known mammalian isozoymes (PADs 1, 2, 3, 4, and 6) that catalyze the post-translational modification of peptidyl-arginine to form peptidyl-citrulline in a variety of protein substrates. Over the past decade the importance of this post …
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Vitamin D Inhibits Expression of Protein Arginine Deiminase 2 and 4 in Experimental Autoimmune Encephalomoyelitis Model Of Multiple Sclerosis
… collection of symptoms. Two enzymes, protein arginine deaminases type 2 and 4 (PAD2 and PAD4) have been implicated to play an etiologic role in demyelination and neurodegeneration by catalyzing a post-translational modification of arginine peptide residues to citrulline. The …
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Kinetic, Mechanistic, and Inhibition Studies On the Deiminase Family of Enzymes
<p>Protein arginine deiminase (PAD) and agmatine deiminase (AgD) both belong to the guanidino-group modifying enzymes superfamily. Although these two enzymes catalyze a similar reaction, the conversion of a guanidinium to a ureido and ammonia, their substrates differ greatly, i.e., …
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Development of Novel Small-Molecule Therapeutics for Multiple Sclerosis
Protein arginine deiminase (PAD) activity is upregulated in MS and the overactive enzymes convert peptidyl arginine on myelin structural proteins to neutral citrulline variants. Hypercitrullination disrupts key ionic interactions between myelin proteins and lipid bilayers that are necessary to …