Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"protein adhesion"”.
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Investigating the molecular origins of biocompatibility : intermolecular interactions between human serum albumin and various chemically modified surfaces via high resolution force spectroscopy
… i.e. thrombosis and inflammation, is the adhesion of blood plasma proteins to the biomaterial surface, which may then initiate platelet adhesion and activation, and thereby set in motion a cascade of adverse host responses. If devices could be developed that prevent that first step from …
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Novel hydrogel polymers
… an in vitro ocular spoilation model and single protein adhesion studies. The results indicate that the sequence distribution and the polarity of the surface affect the adhesion of biological species. Finally, a range of 2-hydroxyethyl methacrylate based copolymer hydrogels containing both …
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Trajectory features as surrogate measures of the nanoparticle-microenvironment interaction space
… space using neural networks, including protein adhesion and nanoparticle cell uptake. We apply similar methods to investigate the role of key nanoparticle features (surface functionality, PEG grafting density, PEG chain length) in determining in vitro and ex vivo transport behavior. This …
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Development and evaluation of anti-biofouling nano-composite coatings
… polymer nanocomposite coatings reduced bacterial adhesion by 70% and 94% respectively, compared with Ni–P–PTFE and stainless steel. The experimental results showed that both type and content of the doped elements in DLC coatings had significant influence on bacterial adhesion. The new doped DLC …
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Synthesis and Characterization of Multicomponent Polyesters via Step-growth Polymerization
… improved the biocompatibility and decreased protein adhesion. The PEG end groups also plasticed the ionic clusters of PET ionomers to decrease melt viscosity, and resulted in a water soluble polyester. Hyperbranched polymers contain a well-defined plurality of peripheral functionalities. …
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Bioadhesion to model thermally responsive surfaces
… and quantitative measurements of the fibroblast adhesion data are provided that support the hypothesis of the mixed SAM exhibiting a dominantly non-fouling molecular conformation at 25 °C whereas it exhibits a dominantly fouling molecular conformation at 40 °C. The adhesion of six model proteins: …
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MOLECULAR PHYSIOLOGY OF BLOOD-BRAIN BARRIER TIGHT JUNCTIONS
… its tight junctions (TJ). Tight junctions are a protein-protein adhesion structures that seal the paracellular space for small solutes. Tight junctions are a common feature in many epithelial and endothelial tissues and a crucial component of the BBB. The BBB tight junctions are shown to be …
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A systematic study of ion-induced nanopatterning on photonic crystal-based label-free optical biosensor
… and chemistry are two main factors affecting protein affinity and conformation on biointerfaces, and the topography and chemistry can be tailored to improve their affinity and adhesion to the surface. It is also known that the presence of nanostructures can increase sensor sensitivity by …
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Protein FOG at the interface between G streptococci and human host defence lines
… human defence lines are investigated. A novel M protein from GGS, denoted FOG, was isolated, recombinantly expressed, and purified. FOG-positive strains survive in human whole blood wheras a FOG-negative strain did not. Addition of soluble FOG, but not protein G, leads to restoration of survival …