Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"protein E"”.
-
The Colonization Strategies of Nontypeable Haemophilus influenzae - Bacterial Colonization Factors and Vaccine Development
… We have shown that the NTHi virulence factor Protein E mediates innate immune evasion by interacting with the C-terminus of host complement down-regulatory protein vitronectin. This interaction delayed the formation of the membrane attack complex on the bacterial surface and increased the …
-
The dissemination of oncogenic RasV12-transformed cells in the adult Drosophila intestine
… Moreover, we demonstrate that the cell adhesion protein E-cadherin (E-cad) is necessary for the invasiveness of RasV12-transformed cells in vivo, challenging the prior perceived principle of the inverse relationship between E-cad levels and cell invasion. We demonstrate that Drosophila …
-
Site-Specific Labelling of the Flavivirus Envelope Protein using Genetic Code Expansion
… global public health burden. The envelope protein (E) orchestrates the processes of virus assembly, budding, and entry into cells and is the primary target of neutralising antibodies. The E proteins arranged on the surface of the virion are not static and pose a dynamic landscape for …
-
Anchoring Energy of Dengue E Protein into Host Membranes and Quaternary Assembly Depend upon Lipid Composition
… structural rearrangements of the envelope protein E leads to the formation of fusogenic E trimers that facilitate membrane fusion with late endosomes. The fusion mechanism is not fully understood, but poses as a key target for inhibiting the viral infection pathway. An important aspect of …
-
Analysis of Synaptotagmin-SNARE Complex Interactions by One-Dimensional NMR Spectroscopy
… neurotransmitter release is mediated by numerous proteins at the neuronal synapse. The SNARE proteins form a complex that mediates fusion between the synaptic vesicle and plasma membrane. The protein synaptotagmin-1 is the major sensor for the calcium concentration. Synaptotagmin-1 and the SNARE …
-
Thioaptamers Targeting Dengue Virus Type-2 Envelope Protein Domain III
… the host cell membrane using surface envelope protein (E). The E protein ectodomain contains three domains, EDI, EDII and EDIII. The highly immunogenic EDIII is the putative receptor binding domain that also binds neutralizing antibodies. Thus, EDIII is an attractive target for development of …
-
Effect of Monounsaturated Fat Rich Almonds on Hemostatic and Inflammatory Factors in Healthy Adults
… by reducing serum total and low-density lipoprotein (LDL) cholesterol. Markers of inflammation including C-reactive protein, E-selectin and interleukin-6 have been proposed to be newer risk factors for cardiovascular disease. However, the influence of nuts such as almonds on markers of …
-
Haemophilus influenzae adhesins and the innate immune response
… H. influenzae expresses several outer membrane proteins of which the adhesins play an important role in the initial interactions with the airway epithelium. In this thesis, we have studied two Haemophilus influenzae adhesins and their interactions with innate defense mechanisms. Vitronectin is a …
-
Proteoliziniu aktyvumu pasižyminčių fermentų biosintezė /
… of a suitable Escherichia coli strain for target protein synthesis, determination of optimal inducer concentration and optimal induction duration. Lastly, purification of target proteins. During the work, seven hypothetical keratin hydrolyzing proteins from Streptomyces sp. SK-91 strain were …
-
Expression and Requirement of Epithelial Fatty Acid- Binding Protein in Neuronal Axon Growth
<p>Epithelial fatty acid-binding protein (E-FABP) is expressed in the dorsal root ganglia following sciatic nerve injury and in migrating and differentiating neurons during neuronal development. It was hypothesized that E-FABP expression is required for the robust outgrowth of axons from developing …
-
New Tools for Structural Biology and Biophysics: High-Throughput Fluorine Solid-State NMR and Applications to Membrane Proteins
… applied to biomolecular systems such as membrane proteins, it can provide access to information about structure and dynamics in native environments, on targets that are difficult to characterize by other biophysical methods. Membrane proteins in particular are critical for biological function and …
-
Energy Landscapes of Hybrid Potentials Based on NMR Data
… topology, and conformational dynamics of proteins is a central tenet of the structure-function paradigm. The NMR hybrid potential, which facilitates the direct incorporation of experimental information into the biomolecualr simulations within the energy landscape framework, is presented. …
-
The regulation of LIV-1 mRNA in MDA-MB-231 human breast cancer cells and its association with E-cadherin (CDH1)
… with the expression of the cell adhesion protein, E-cadherin (CDH1), thought to play a role in metastasis. In the present study, we investigated the regulation of LIV-1 and its relationship to CDH1 in MDA-MB-231 ER<sup>-</sup> breast cancer cells. Cells were treated with insulin and EGF …
-
Caracterización funcional de Snail2 como represor de cadherina- E y como regulador del proceso de carcinogenésis química
The loss of expression of intercellular adhesion protein E-cadherin is a key event in the process of epithelial-mesenchymal transition (EMT), which allows cell migration during embryonic development and invasion of tumor cells of epithelial origin (carcinomas). The transcriptional repression is one …
-
Invasive disease by Haemophilus influenzae in Sweden in the era of the H. influenzae type b vaccine
… the extracellular matrix through the adhesin Protein E was confirmed. Binding to complement regulators was not higher in invasive as compared to nasopharyngeal NTHi isolates, and thus did not seem central for invasive capacity. Speculation, but no comprehensive conclusion as to what host …
-
Crosstalk Between Calcium Signaling and Lipid Metabolism at Endoplasmic Reticulum-Plasma Membrane Junctions
… PI from the ER to the PM by PI transfer proteins (PITPs) is therefore postulated to support PM PIP2 replenishment. Such transfer is more likely to take place at ER-PM junctions, since the close apposition of the ER and the PM enables PITPs to efficiently interact with two heterologous …
-
Isolierung und strukturelle Charakterisierung von E-Selektin-bindenden Gangliosiden aus humanen Granulozyten
… drei bekannten Selektine (L-, E- und P-Selektin) Proteine identifiziert, die die Fähigkeit zur Adhäsion zeigten. Das Hauptepitop des E-Selektin-Rezeptors ESL-1 konnte als das Tetrasaccharid sLe x (Neu5Ac[alpha]2-3Gal[beta]1-4(Fuc[alpha]1-3)GlcNAc) charakterisiert werden. Da auch Glykolipide …
-
The Role of GM-CSF/IL-3/IL-5 Receptor Common β Subunit (CBS) in Hematopoietic Stem and Progenitor Cell (HSPC) Expansion, Monocytosis and Atherosclerosis
… models of atherosclerosis including Apolipo protein E knockout (Apoe-/-) mice and ATP binding cassette transporter A1(ABCA1) and ATP binding cassette transporter G1 (ABCG1) knockout (Abca1-/-Abcg1-/-) mice demonstrated that cellular cholesterol retention leads to Hematopoietic Stem and …
-
Structural Dynamics and Signaling Roles of the Aer PAS and F1 Regions
… and signal transduction. I found that Aer mutant proteins did not require FAD binding for maturation and stability. However, lesions that appeared to disrupt PAS-HAMP interaction and/or proper folding of the FAD binding pocket inhibited maturation and increased proteolysis. The most consequential …