Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 715 for “"protects"”.
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Gaucher Disease Protects Against Tuberculosis
Biallelic mutations in the glucocerebrosidase (GBA1) gene cause Gaucher disease, characterized by lysosomal accumulation of glucosylceramide and glucosylsphingosine in macrophages. This and other lysosomal diseases occur with high frequency in Ashkenazi Jews. It has been proposed that the …
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
<p>Reactive oxygen species are implicated in tissue damage in many cardiovascular diseases. The current study was designed to test the hypothesis that exposure to high inspired oxygen concentrations (100%) damages cardiac mitochondria and that a biogenic response is needed for cell survival. The …
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N-Glycosylation Protects Host from Mycobacterial Infection
Host immunity against tuberculosis (TB) is primarily mediated by macrophages. Macrophages phagocytose *Mycobacterium tuberculosis* and restrict their growth. Through a zebrafish forward genetic screen, we have identified the early steps of N-glycosylation are required for the macrophage to resist …
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The Apollo Nuclease Binds To TRF2 and Protects
<p>Members of the β-CASP family of proteins are involved in DNA repair and RNA processing. We identified a member of this family of enzymes, hSNM1B/Apollo, in complex with the telomere binding proteins TRF2/Rap1. Due to its low abundance at telomeres, we consider Apollo to be a telomere accessory …
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SIRT6 Overexpression Protects Against Diet-Induced Diabetes in Mice
Numerous studies in a variety of species indicate that caloric restriction (CR) elicits beneficial metabolic effects including reduced adiposity and improved glucose homeostasis, as well as enhanced insulin and leptin sensitivity. Conversely, chronic feeding on high caloric diets brings about …
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Heme Peroxidase Hpx-2 Protects Caenorhabditis Elegans From Pathogens
<p>Heme-containing peroxidases are important components of innate immunity. Many of them functionally associate with NADPH oxidase (NOX)/dual oxidase (DUOX) enzymes by using the hydrogen peroxide they generate in downstream reactions. In <em>Caenorhabditis elegans,</em> a ShkT-containing …
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Prolylcarboxypeptidase protects from vascular dysfunction and promotes vascular repair
… femoral artery. In sum, this work suggests PRCP protects from the pathological manifestations of vascular dysfunction and promotes angiogenesis and large vessel repair.
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Transcription factor Pax6 protects mouse cortical cell fate specification
… the results support the hypothesis that Pax6 protects cortical PC specification by inhibiting interneuron-inducing signals.
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Low-grade aldehyde stress protects mice from diet-induced obesity
DNA damage is a form of cellular stress that can have drastic consequences on the level of the cell, tissue, and whole organism. In mammals, DNA can be damaged through endogenous and exogenous damaging agents and intricate protection pathways have evolved to safeguard the genome, which include …
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Architectural Healing Spaces: How Design Protects, Rehabilitates Survivors of Abuse
This dissertation delves into an exploration of the profound potential of architectural interventions in facilitating the healing process for survivors of abuse, with a particular focus on women and children. Acknowledging the significance of environments that promote user comfort, personal …
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The mechanism by which manganese protects Escherichia coli from hydrogen peroxide
… to understand the mechanism by which manganese protects cells against reactive oxygen species, particularly H2O2. We showed while manganese transport mutants, mntH, have no growth defect, mntH mutants in strains that cannot scavenge H2O2, Hpx- mntH, failed to grow when cultured aerobically. Thus …
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West Nile virus vaccination protects against Usutu virus disease in mice
… against USUV. Whether prior WNV exposure protects against USUV disease is also unknown. The main goal of this thesis was to characterize how a primary flavivirus exposure would influence a secondary flavivirus exposure; specifically, we wanted to observe if WNV exposure would protect …
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A novel low-density lipoprotein receptor-related protein protects against environmental teratogens
Congenital malformations are the leading cause of infant mortality in the United States, and 2% of all live births have some form of malformation. While many of these malformations have known genetic or environmental causes, others have eluded explanation. These conditions are thought to be caused …
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Investigating the mechanisms by which PINK1 protects against Parkinson's disease
… to investigate the mechanisms by which PINK1 protects against PD, with a focus on PI3-kinase/Akt signalling. Akt signalling is central to cell survival, metabolism, protein and lipid homeostasis, and is impaired in PD. Akt activation is reduced in the PD brain, and by many PD-causing genes, …
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Endothelial Cell-Specific Knockout of Meis1 Protects Ischemic Hindlimb Through Vascular Remodeling
Peripheral artery disease (PAD) affects more than 200 million people worldwide. PAD refers to illness due to a reduction or complete occlusion of blood flow in the artery, especially to the extremities in disease conditions, such as atherosclerosis or diabetes. Critical limb ischemia (CLI) is a …
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Overexpression of Heat Shock Factor 1 Protects against Pathological Proteins in Neurodegenerative Diseases
A classical feature of neurodegenerative disorders is the accumulation of protein aggregates, such as TAR DNA/RNA binding protein (TDP-43) and superoxide dismutase 1 (SOD1), which lead to neuronal dysfunction and loss. Therefore, molecules that maintain protein homeostasis may be beneficial …
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RESPIRABLE SIRNA TARGETING AT THE NF-KB PATHWAY PROTECTS AGAINST INFLAMMATORY LUNG DISEASES
Asthma and chronic obstructive pulmonary disease (COPD) are common inflammatory pulmonary diseases. Cumulative evidences have shown the role of NF-kB signaling pathway in the pathogenesis of asthma and COPD. Ribosomal protein S3 (RPS3) is a subunit of NF-kB complex while receptor-interacting …
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The Transcription Factor ATF5 Protects Cortical Neurons from Toxicity Induced by Prostaglandin J2
<p>Mitochondrial dysfunction has been recognized to play a central role in the pathogenesis of neurodegenerative disorders, including Parkinson’s and Alzheimer’s disease. Transcription factor ATF5 has been shown to mediate an endogenous stress pathway known as the UPR<sup>mt</sup>, a prosurvival …
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STING safeguards epithelial genome integrity and protects from carcinogenesis via mitotic checkpoint control
The cGAS-STING pathway is widely recognized as a central mediator of innate immune responses to cytosolic DNA. However, whether cGAS-STING directly coordinates DNA damage response in non-immune cells and thereby contributes to cell-intrinsic prevention of oncogenesis is not known. The present work …
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