Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 104 for “"protective immunity"”.
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Protective Immunity in Atherosclerosis
… inhibit the development of atherosclerosis. The protective immunity induced by the apoB-100 peptide vaccine aBp210 is associated with an activation of Tregs indicating that specific activation of Tregs could be a promising target in immune modulating therapies. Activation of the inhibitory …
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Trichuris Muris Whey Acidic Protein Induces Type 2 Protective Immunity Against Whipworm
… be an ideal, cost-effective strategy to induce protective immunity, leading to control of infection and transmission. Here we report the identification of whey acidic protein, a whipworm<em> </em>secretory protein, as a strong immunogen for inducing protective efficacy in a surrogate mouse …
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Identifying Merozoite Targets of Protective Immunity Against <i>Plasmodium falciparum</i> Malaria
… infected with <i>P. falciparum</i> can acquire immunity, first to severe, then to uncomplicated clinical episodes of malaria, and finally to high parasite densities, provides hope that a vaccine is achievable. Immunoglobulins have been identified as a key component of naturally acquired immunity …
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MyD88-Mediated Signaling in Protective Immunity against an Attenuated West Nile Virus Infection
… underlying mechanisms of WNV NS4B-P38G induced protective immunity. Toll-like receptor (TLR) 7/myeloid differentiation factor 88 (MyD88)-mediated signaling pathways protect host against wild-type WNV infection. Both MyD88-/- and TLR7-/- mice had reduced effector T cell functions compared to …
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Protective Immunity in Mice Immunized with the Nfa1 Protein for Pathogenic Naegleria fowleri Infection
… animals. In the present study, to examine the protective immunity of the Nfa1 protein for N. fowleri infection in a mouse model, BALB/c mice were immunized with the Nfa1 protein either by intraperitoneal or intranasal route, and then infected intranasally with N. fowleri trophozoites. In …
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The role of cell type-specific tumour necrosis factor in protective immunity against neurotuberculosis
… of cerebral M. tuberculosis infection and its protective immune response. In this study, we investigated the role of tumour necrosis factor derived from neurons, microglia/macrophages, neutrophils, CD4+ and CD8+ T cells in host immunity against M. tuberculosis; using an experimental murine …
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Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells
… have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that is currently not well defined. Recently, it has been …
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Correlates of protective immunity in individuals who are exposed to Hepatitis C but appear uninfected
… against repeated exposures. In summary, cellular immunity against HCV is evident in some seronegative high risk subjects, suggesting that the cellular immune responses may efficiently facilitate viral clearance. Understanding the mechanisms of this immune response pattern will allow better …
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Measurement of the Cell-Mediated Immune Response in Cattle Induced by Virulent and Attenuated Strains of Anaplasma Marginale Introduced in Both Live and Killed Form and Correlation With Protective Immunity
Made available in DSpace on 2014-12-14T13:28:15Z (GMT). No. of bitstreams: 1 7606715.pdf: 5690049 bytes, checksum: 0d989004947e09c1834a52f8fc8701c2 (MD5) Previous issue date: 1975
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Resistance to hepatitis C virus : potential genetic and immunological determinants
… to infection. In addition, evidence for protective immunity has been found in some HESN groups, such as sex workers in the Gambia. Population studies of those at high risk for hepatitis C virus (HCV) infection suggest that a HESN phenotype exists. There is a growing body of evidence for …
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The role of the cytolytic mediators, granulysin and perforin, in tuberculosis
Protective immunity against mycobacterial infection requires an effective cytolytic response, in addition to an intact Type l (Th1) cytokine pathway. Natural killer (NK) cells and cytolytic T-cells (CTL) are essential components of protective immunity against tuberculosis (TB) and mediate …
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The Function of PTPN22 and the Autoimmune Risk Variant LypW in Immune Responses to Vaccination
… and Interferon upregulation all contribute to protective immunity that occurs in humans following influenza immunization. Hematopoietic cell-specific PTPN22 encodes Lymphoid Phosphatase (Lyp), which regulates lymphocyte antigen receptor and Pattern Recognition Receptor (PRR) signaling. A PTPN22 …
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Development of a Nanoparticle Vaccine Delivery System with Polymeric Oral Adjuvants for Poultry
… a lack of new adjuvants to enable development of protective immunity using different vaccine delivery methods. A vaccine delivery system using oral adjuvants would be applicable across species for both individual and mass vaccination in both the medical and veterinary fields. We sought to create …
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Development of a Murine Model of Severe Scrub Typhus And Its Use to Elucidate the Immune Response to and The Pathology that Occurs during Orientia Tsutsugamushi Infection.
… vaccine for scrub typhus, and the mechanisms of protective immunity are poorly understood. Scrub typhus is a disseminated infection of endothelial cells by the obligately intracellular bacterium Orientia tsutsugamushi. Mechanistic studies of immunity have been performed primarily in …
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Growth of luciferase-transfected BCG in whole blood : use of a novel assay to study immune responses to mycobacteria in children
… vaccine, a comprehensive understanding of protective immunity in adults and children is needed. Studies involving host-pathogen interactions are complex and have been hampered by the slow growth of mycobacterial organisms.
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The role of TNFRp55 and TNFRp75 in the host immune response to Mycobacterium tuberculosis
… factor alpha (TNFα) is critical for host protective immunity against Mycobacterium tuberculosis infection. TNFRp55 and TNFRp75 can both bind TNFα and conduct signaling, however the respective roles, in particular that of TNFRp75 in an M. tuberculosis aerosol inhalation infection was poorly …
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Innate Immunity to Listeria monocytogenes Infection: Regulation of Dendritic Cell and Neutrophil Responses by MyD88 and the Type I IFN Receptor
… to the host cytosol, and this correlates with protective immunity.
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The role of dendritic cells in rickettsial infection; initation of early immunity to spotted fever group Rickettsiae
… in determining the characteristics which elicit protective immunity. Previous data imply that Th1 responses are essential for immunity to rickettsiae; however, they do not address mechanisms important in initiating early immunity, particularly those involving dendritic cells. Dendritic cells are …
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Characterization of Alpha-Galactosylceramide As A Mucosal Adjuvant
… which are more biologically relevant for protective immunity against pathogens transmitted by the mucosal routes. Adjuvants possess the inherent capacity to bridge innate and adaptive immune responses through activating innate immune mediators. Here evidence is presented in support of the …
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The effect of HIV-exposure on immune responses to expanded programme on immunization vaccines and antigens
… to infectious diseases and makes induction of protective immunity via vaccines a challenge. HIV-exposed infants are HIV uninfected and born to HIV-infected mothers and have increased morbidity and mortality of unknown aetiology. We hypothesise that T cells of HIV-exposed uninfected (HEU) …
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