Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"protective group"”.
-
Catalytic antibodies for amide cleavage and prodrug activation
… showed that the nucleophilic phenolic hydroxyl group is essential for catalysis, much like amide hydrolysis catalyzed by serine proteases. The second part of the thesis describes the generation of catalytic antibodies capable of removing a protection group for the simultaneous activation of …
-
Conjugate Additions and Transposition of the Allylic Alcohols of Enol Ethers of 1, 2-Cyclohexanedione.
… problems were encountered and so an alternative protective group the methoxymethyl acetal was prepared and studied. Alkylation of these derivatives was successful; however, the oxidation was problematic and although evidence for rearrangement was observed in one case, it did not provide the …
-
Ring-Opening of Aziridine -2 -Carboxamides by Carbohydrate C1-O Nucleophiles. Stereoselective Preparation of O-Linked Glycopeptides
… the presence of the native carbohydrate C2-NHAc group. Other classes of 0-glycosyl serine constructs, such as the beta-GlcNAc-Ser and alpha-Man-Ser linkages, are also prepared by this approach. In the course of these studies, the ortho-allylbenzyl (ABn) moiety was developed as a new C-terminus …
-
Photocontrol of Antibacterial Activity
… approach and the use of photoreleasable protective groups to cage drugs. Photopharmacology is based on bioactive molecules that incorporate in their structure a molecular switch. The photoactive moiety can undergo an isomerization process that induces changes in the molecule properties …
-
Palladium catalysis in the synthesis of polyaniline-related materials
… reaction, in conjunction with an orthogonal protective group scheme, forms the basis of two routes to oligoaniline precursors. One method consists of a bidirectional chain growth from a symmetric core piece, whereas the other involves a divergent-convergent synthesis of nonsymmetric …
-
Regioselective Synthesis of Cellulose Derivatives
… a simple homopolymer with three hydroxyl groups, differing only subtly in reactivity. The position of substitution has a powerful influence on physical properties of cellulose derivatives. To better understand the structure and property relationships of cellulose derivatives, it is …
-
Non-heme iron C-H oxidation: tolerance of nitrogen-containing motifs with application to amino-acid and peptide oxidation
… of predictable selectivity and even directing group effects. In addition, the PDP ligand framework has been shown amenable to various steric and electronic modifications, allowing for tuning of reactivity and selectivity. Key limitations are still prevalent in the methodology, however, …
-
Control of regioselectivity:oxidation and deprotection
… isotope effect is found. The use of benzyl (Bn) groups is one of the most common methods used in synthesis to protect alcohols and amines. The method of choice for the removal of Bn groups is hydrogenolysis over a palladium catalyst. Oxidative deprotection methods are also available, particularly …
-
Optimalisation de la radiosynthèse et production au niveau de la curie d'acides aminés aromatiques marqués au fluor-18
… Different starting precursors with more labile protective groups than the methoxy were synthesized and evaluated. Among these compounds, the isopropyl ether protective group seems the more advantageous. By exploiting the advantages of the improvements to the chemistry described in this work and …
-
Asian immigrants’ psychological well-being: the interplay of perceived racial discrimination, group membership, and coping strategies
… the moderating effects of immigrants’ group membership and coping factors. The main research hypotheses and exploratory research questions include the following: 1) Does perceived discrimination effect Asian immigrants’ psychological well-being (i.e., psychological stress and overall …