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Showing 1 to 18 of 18 for “"protective antigen"”.

  1. Protective antigen-mediated delivery of biomolecules

    Lu, Zeyu (Zeyu Mike)Massachusetts Institute of Technology2018

    … and proteins remains a key challenge today. Protective antigen, a naturally evolved protein translocase derived from Bacillus anthracis, has shown promise as a platform of protein delivery due to its ability to form a transmembrane pore that allows the cargo to have cytosolic access. We and …

    mit Repository record

  2. 19F-NMR studies on anthrax toxin protective antigen

    Chadegani, Fatemeh2014

    wichita-thes

  3. A Nanoliposomal Adjuvant Containing Cobalt-Porphyrin Phospholipids for Anthrax Protective Antigen

    Lin, CuiyanState University of New York at Buffalo2019

    M.S.

    buffalo Repository record

  4. Expression of Bacillus Anthracis Protective Antigen in Vaccine Strain Brucella Abortus Rb51

    Poff, Sherry AnnVirginia Tech1997

    … RB51 has been shown to be useful in eliciting protective cell mediated immunity and humoral responses against Brucella in cattle and other animal species. Since the protective antigen (PA) of B. anthracis is known to induce protective antibodies, it was decided that the objective of this …

    vt Repository record

  5. Biochemical characterisation of the translocation of material through the protective antigen (PA) Pore

    Shorter, Susan AmandaUniversity of Greenwich2017

    … lethal factor (LF) and oedema factor (EF), and protective antigen of 83 kDa (PA83). This toxin complex mediates cytosolic entry through the formation of an oligomeric PA pore, facilitating translocation of LF and EF, an event critical for EF and LF to exert their cytotoxic effects. The …

    greenwich Repository record

  6. Investigation of the pH dependent conformational changes of anthrax protective antigen and interactions with its cellular receptor

    Rajapaksha, Maheshinie2011

    wichita-thes

  7. Fluorescence studies on anthrax protective antigen pore formation and in the presence of the host receptor, CMG2

    Andra, Kiran K.2013

    wichita-thes

  8. Structural and stability studies on domain IV of anthrax toxin protective antigen (PA); its role in anthrax pathogenesis

    Mamillapalli, Sireesha2018

    wichita-thes

  9. THE ROLE OF OUTER MEMBRANE PROTEIN A IN ANAPLASMA MARGINALE CELLULAR INVASION AND ITS POTENTIAL AS A CROSS-PROTECTIVE ANTIGEN

    Emani, Sarvani2023

    … Both diseases can be severe, even fatal, and protective vaccines for each are lacking. We recently identified A. phagocytophilum outer membrane protein A (ApOmpA) as being critical for cellular invasion and is expressed during infection of mammalian but not tick cells. Disrupting ApOmpA-host …

    vcu Repository record

  10. The construction and characterization of recombinant sindbis virus vectors as a platform for anthrax vaccine development

    Thomas, JohnThe University of Texas Medical Branch2008

    … be maintained to ensure continued protection. Protective antigen (PA), the chief component of AVA, is an 83kDa protein responsible for binding host cell receptors and promoting toxin entry into susceptible cells. Analysis of the PA molecule has identified a specific region, termed domain four, …

    utmb Repository record

  11. Expression strategies for plant-based production of a vaccine adjuvant

    Verbiest, LeenVirginia Tech2000

    … plants. First, the expression level of foreign antigens tends to be low and second, co-expression of an adjuvant may be required to facilitate an appropriate immune response. Ricin, a plant toxin that survives the human digestive process, has been proven to stimulate an immune response and could …

    vt Repository record

  12. Analysis and optimization of immune responses elicited by Outer Membrane Vesicles (OMVs)

    Croia, LorenzoUniversità degli studi di Trento2023

    … lipoproteins and can be decorated with foreign antigens. Thanks to these properties OMVs are becoming an attractive vaccine platform. However, a systematic investigation on the potentiality of OMVs to design vaccines to elicit protective antigen-specific T and B cell responses is missing. In …

    trento Repository record

  13. Induction of Protection, Antibodies and Cell Mediated Immune Responses by Brucella Abortus Strain RB51, Ochrobactrum Anthropi and Recombinants Thereof

    He, YongqunVirginia Tech1999

    … and recombinant strain 49237 expressing Brucella protective antigen copper-zinc superoxide dismutase (Cu/Zn SOD) induced a mix of Th1 and Th2 type immune responses but failed to provide protection against virulent Brucella challenge. After changing the immune response to a predominantly Th1 type …

    vt Repository record

  14. Evaluation Of Immunogenicity Of Transgenic Chloroplast Derived Protect

    Koya, Vijay

    … anthracis with the principle component being protective antigen (PA83). Evaluation of anthrax vaccine given to nearly 400,000 US military personnel by Vaccine Adverse Event Reporting System (VAERS) showed adverse effects such as flu-like symptoms, local pain, large degree of inflammation, …

    ucf

  15. Development of Brucella abortus RB51 as a Vaccine to Protect Against Brucellosis and Anthrax

    Poff-Reichow, Sherry AnnVirginia Tech1999

    … RB51 has been shown to be useful in eliciting protective CMI and antibody responses against Brucella in cattle and other animal species. Since the protective antigen (PA) of B. anthracis is known to induce antibodies, the pag gene encoding PA was expressed in B. abortus RB51, producing a dual …

    vt Repository record

  16. Identification and Characterization of Novel Melioidosis Vaccine Candidates

    Schmidt, Lindsey2021

    … the literature we identified AhpC as a potential protective antigen. AhpC is a constitutively expressed peroxiredoxin involved in oxidative stress reduction. We first inactivated AhpC by introducing a glycine substitution at Cys57 (AhpCC57G), which is the peroxidatic cysteine residue critical for …

    unr Repository record

  17. Roles of Small Rnas and Paralogous Proteins In Bacillus Anthracis Virulence Gene Regulation

    Corsi, Ileana, <p>http://www.orcid.org/0000-0002-5422-9105</p>2023

    … bind DNA. The <em>pagA</em> gene, encoding the protective antigen component of the anthrax toxin of <em>B. anthracis</em>, is part of a bicistronic operon that codes for its own repressor, the dimeric protein PagR1. PagR1 also regulates <em>sap</em> and <em>eag</em>, two genes encoding …

    uthsc Repository record

  18. Prophylaxis of disease caused by bacterial pathogens of man

    TITBALL, RICHARD WILLIAM2001

    … tularemia is documented. Two surface antigens (lipopolysaccharide and FopA) have been evaluated as sub-unit vaccines. Of these, lipopolysaccharide shows potential as a protective antigen. However, because of the paucity of information available on this bacterium, a wider approach to …

    plymouth Repository record