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Showing 1 to 20 of 37 for “"proteasome inhibitor"”.
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STRUCTURAL AND FUNCTIONAL STUDIES OF F-BOX-ONLY PROTEIN FBXO7 AND ITS INTERACTIONS WITH PROTEASOME INHIBITOR PI31
… interaction with its protein partners, such as proteasome inhibitor PI31. The best known biological function of Fbxo7 is its role as the substrate-recognition subunit of the SCFFbxo7 (Skp1-Cul1-F-box protein) E3 ubiquitin ligase that catalyzes the ubiquitination of hepatoma up-regulated protein …
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Mechanisms Underlying The Heterogeneous Sensitivities of Cancer Cells to Proteasome Inhibitors
<p>The mechanisms underlying cellular response to proteasome inhibitors have not been clearly elucidated in solid tumor models. Evidence suggests that the ability of a cell to manage the amount of proteotoxic stress following proteasome inhibition dictates survival. In this study using the …
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Proteasome Inhibition As A Potential Anti-Breast Cancer Therapy: Mechanisms Of Action And Resistance-Reversing Strategies
<p>AMPK activation and Ubiquitin Proteasome System (UPS) inhibition have gained great attention as therapeutic strategies for the treatment of certain types of cancers. While AMPK serves as a master regulator of cellular metabolism, UPS regulates protein homeostasis. Although the crosstalk between …
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Investigating new roles of the ubiquitin proteasome system in cell death and innate immune signalling
… of some regulators of the ubiquitination and proteasome systems in cell death and innate immune signalling pathways in macrophages. Initial studies focused on a form of regulated cell death termed necroptosis, a type of cell death mediated by the receptor-interacting protein kinases (RIP). RIP …
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Proteasome Inhibition Enhances The Effect of Bikdd Gene Therapy
… pancreatic cancer. In this study, we proposed proteasome inhibition as a combinational therapy strategy with BikDD gene therapy to enhance the clinical benefits. Proteasome inhibition stabilized exogenously expressed BikDD protein, and significantly enhanced the apoptosis induction effect of …
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Role of ATG 5 in ER stress-induced apoptosis in meniscus.
… that alleviates ER stress or with MG-132, a proteasome inhibitor, restored normal levels of ATG 5. Taken together our data suggest that FFA palmitate induces ER stress in meniscus cells, decreases autophagy and promotes cell death. This is the first study to demonstrate that ER stress …
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New Roles for the Integrated Stress Response in Cancer and Proteostasis
… proteostasis in response to the chemotherapy and proteasome inhibitor, bortezomib. We found this second finding to be mechanistically linked to a previously-undescribed role for the ISR in regulating the microtubule cytoskeleton to promote the removal of aggregated proteins. As a second goal of …
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Exploring the link between RAG1 Cellular Distribution and Components of the CRL4DCAF1 E3 Ligase
… the CRL4DCAF1 E3 ubiquitin ligase, and the 26S proteasome. RAG1 sequestration in nucleoli and nuclear puncta have been implicated in regulating its activity. RAG1 nucleolar egress and puncta formation are dependent on the same domain as DCAF1 association. We investigated whether DCAF1 or the …
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Evaluation of the therapeutic potential of Akt inhibition in a translational model of histiocytic sarcoma
… effective treatment options. Akt signaling and proteasome dysfunction have been implicated in the pathogenesis of the disease, both in humans and dogs. Our work aims to investigate the importance of the Akt signaling pathway and evaluate the potential of Akt-targeted therapy in a canine model of …
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Nutlin-3 sensitizes cancer cells to bortezomib via induction of paraptosis-associated cell death
The ubiquitin-proteasome system is a complex and tightly controlled system in charge of degrading 80-90% of proteins, and is central to regulating cellular function and keeping protein homeostasis. Since proteasome inhibition can lead to the accumulation of the misfolded proteins and subsequent …
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Activation Of Tumor Cell Death Program By Targeting The Ubiquitin-Proteasome Pathway: Significance In Cancer Treatment And Prevention
… CELL DEATH PROGRAM BY TARGETING THE UBIQUITIN-PROTEASOME PATHWAY: SIGNIFICANCE IN CANCER TREATMENT AND PREVENTION</p> <p>by</p> <p>MICHAEL FREZZA</p> <p>August 2010</p> <p>Advisor: Dr. Q. Ping Dou</p> <p>Major: Cancer Biology</p> <p>Degree: Doctor of Philosophy</p> <p>The ubiquitin-proteasome …
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Molecular Studies On The Anti-Tumor Effects Of Metal-Based Complexes: Involvement Of The Ubiquitin-Proteasome And Apoptotic Pathways
<p>The ubiquitin-proteasome pathway is crucial to normal cellular function, and as such, has been extensively investigated as a potential target for cancer therapeutics. Many compounds have been tested for their proteasome inhibitory ability, including various small peptide aldehydes, and, …
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Ehrlichia chaffeensis TRP32 is a Nucleomodulin that Regulates Host Gene Expression and Post-Translational Modifications Determine its Localization and Function
… TRP32 was not responsive to treatment with the proteasome inhibitor carfilzomib. An electromobility shift assay (EMSA) demonstrated TRP32 binding to host DNA via its tandem repeat domain. TRP32 DNA binding and motif preference were further confirmed by supershift assays, as well as competition …
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Induction of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma
… of only 14 months with current treatment. The proteasome inhibitor bortezomib (BTZ) shows efficacy in cancers like myeloma, but its clinical utility in other cancer types has been more limited. Newer proteasome inhibitors such as marizomib (MRZ) have unique inhibitory and death inducing …
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Mechanisms of Astrocyte Contribution to Bortezomib-Induced Peripheral Neuropathy
<p>Bortezomib is a proteasome inhibitor used in the treatment of multiple myeloma and other non-solid malignancies, alone or in combination with other chemotherapy drugs. Like other chemotherapeutic agents, bortezomib treatment is frequently accompanied by chemotherapy-induced peripheral neuropathy …
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Proteolysis-targeting chimeras as a novel strategy for targeting epigenetic mechanisms in Plasmodium falciparum parasites
… efforts aim to identify small-molecule inhibitors that bind to the active site of essential target proteins, thereby killing the causative organism, Plasmodium falciparum. However, such active site-dependent inhibitors face the major challenge of resistance development. We therefore …
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Mesenchymal Stem Cells Therapy in Progressive Rat Model of Parkinson's Disease
… and progressive SD rat model of PD using MG-132, proteasome inhibitor. Immunocytochemical analyses in primary mesencephalic culture revealed that hMSC treatment increased dopaminergic neuronal survival compared to dopaminergic neuronal death in MG-132 treatment. Additionally, hMSCs treatment …
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Molecular Adaptation of Pancreatic Beta-Cell Function During Endoplasmic Reticulum Stress
… insulin synthesis and secretion with the proteasome activity to regulate protein concentrations in the endoplasmic reticulum (ER). During this process, reactive oxygen species (ROS) may originate as byproducts from the oxidative protein folding machinery in the ER, especially during an …
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Expression of the repressor element-1 silencing transcription factor (REST) is regulated by IGF-I and PKC in human neuroblastoma cells
… Supporting these data, the exposure to PKC inhibitors (GF10923X and Gö6976) and PMA (16nM) reverted the effects observed with PMA alone. REST levels were related to morphological differentiation, expression of growth coneassociated protein 43 (GAP-43; a gene not regulated by REST) and of …
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