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Showing 1 to 4 of 4 for “"proteasome assembly"”.
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Investigating the early events in proteasome assembly
Proteasome assembly is a rapid and highly sequential process that occurs through a series of intermediates. While the quest to understand the exact process of assembly is ongoing, there remains an incomplete understanding of what happens early on during the process, prior to the involvement of the …
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Role Of The Pkna And Pknb Kinases In Mycobacterium Tuberculosis
… Proteomic search led to identification of proteasome to be a substrate of PknA and PknB in M. tuberculosis. Furthermore, I demonstrate that the phosphorylation of PrcA and PrcB by PknA regulates processing of Pre-PrcB. Additionally, I show that PknA phosphorylation of pre-PrcB and PrcA …
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Inhibition of pancreatic cancer progression through EMT inhibition and induction of ER stress
… for 6 weeks. Mechanistically, C150 enhanced proteasome-mediated degradation of Snail protein, an important EMT-promoting transcription factor, and decreased the mesenchymal marker N-cadherin, while it increased the epithelial markers ZO-1 and Claudin-1. Findings from this first part of the …
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Compromising the 20S Proteasome Activates a Quality Control Pathway to Mitigate Proteotoxic Stress
<p>The regulation of the ubiquitin-proteasome system (UPS) has been the subject of a vast body of work because of its implication in normal development and a wide range of diseases. The UPS controls the degradation of a large number of cellular proteins and thereby regulates essential cellular …