Global ETD Search
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Showing 1 to 2 of 2 for “"protamine 2"”.
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The Role of 5-Hydroxymethylcytosine in Genome Instability
… Finally, this thesis also explores the role of protamine in mediating paternal genome stability. The protamines, PRM1 and PRM2, displace canonical histones during the final stages of sperm development, a process that must be correctly achieved to maintain male fertility. PRM2 is subject to …
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Characterization of the Genes Essential for Mouse Spermatogenesis
… of DNA to denaturation and elevated levels of protamine 2 precursors. Injection of mutant cauda epididymal sperm into intact oocyte showed normal fertilization rates, however, most zygotes didn't develop beyond the 2-cell stage. Single cell PCR revealed that the mRNA expression profile was …