Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"prostate carcinogenesis"”.
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Estrogen receptor beta modulates prostate carcinogenesis
Prostate cancer (PC) is characterised by dependence upon androgen receptor (AR) as its driving oncogene. When organ-confined, radical treatment can be curative, however there is no cure for advanced, castration-resistant prostate cancer (CRPC). There is therefore a need to better understand the …
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Dietary interventions for reduction of prostate carcinogenesis in rodent models
Prostate cancer (PCa) is the second leading cause of cancer and cancer related deaths in U.S. men; thus, identifying strategies to reduce PCa incidence could have a significant impact on public health. Epidemiological studies have supported the hypotheses that dietary intake of soy foods or tomato …
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Enrichment of tomatoes and broccoli with specific bioactives for the reduction of prostate carcinogenesis
… and cruciferous vegetables to decreased risk of prostate cancer. Several bioactive components isolated from cruciferous vegetables and tomatoes exhibit anti-cancer properties. Previous studies have evaluated the cancer preventive potential of these individual bioactives, but few have examined …
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The role of tomato and lycopene consumption on prostate carcinogenesis and prostate cancer treatment
Prostate cancer (PCa) is most commonly diagnosed cancer among men in the United States. Following PCa diagnosis, men often seek information about foods and supplements that may improve their response to therapies, quality of life and survival. Tomatoes and their primary bioactive (lycopene) are one …
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The Influence of Beta-Carotene and Lycopene on Human Prostate Tumor Cells in Vitro and Human Prostate Tumors in Mice
… the influence of tomatoes, BC and lycopene on prostate carcinogenesis under biologically relevant conditions. To this end, a novel approach for the delivery of carotenoids to cells in culture and a murine model were developed. There was no evidence from the athymic model that whole tomato or …
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Testosterone, Lycopene Isomers, and Prostate Cancer
… (NMU)-testosterone-induced prostate cancer in rats. Survival was analyzed to include only rats that died with adenocarcinomas of the accessory sex glands. Only tomato powder-fed (RR = 0.570; P = 0.009) rats experienced significantly increased survival as compared to placebo …
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The Role of 5-Alpha Reductase 3 In Steroid Metabolism
… <p>The growth and development of prostate cancer is largely driven by androgen mediated signaling. The 5-alpha reductase family of enzymes plays an essential role in the conversion of testosterone to the more potent androgen, 5-alpha dihydrotestosterone (DHT), which is capable of …
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The Cellular and Molecular Properties of Flavinoids in Prostate Cancer Chemoprevention
… as candidate agents for chemoprevention in prostate cancer. Despite the large number of known flavonoids (over 9000), only a few have been studied in prostate cancer to date. The work presented in this thesis describes the identification of novel anti-proliferative flavonoids, their …
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Phage Display Library Screening For Psa-/Lo Prostate Cancer Cell-Binding Peptides
<p>Prostate cancer (PCa) is one of the leading malignancies affecting men worldwide. Our lab focuses on understanding the molecular mechanisms underlying prostate carcinogenesis and developing therapeutics that target the cells responsible for driving PCa and mediating therapy resistance. My master …