Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"prostaglandin synthase"”.
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Inhibition and inactivation of prostaglandin synthase-2 and horseradish peroxidase
Prostaglandin synthase (PGHS) is a bifunctional enzyme of particular pharmaceutical interest, containing both cyclooxygenase (COX) and peroxidase (POX) active sites. Development of PGHS-2-selective POX inhibitors may reduce the toxic and carcinogenic effects of PGHS-2 xenobiotic activation, as well …
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The Efficacy Of Prostaglandin Synthase Inhibition On Attenuating Pressure Overload Induced Cardiac Remodeling
… specific mechanistic pathways associated with prostaglandin D2 (PGD2) mediated fibrotic response. At the 14 day period, pressure overloaded animals shosignificant changes in LV structural and functional parameters. Cyclooxygenase-2 (COX-2) inhibition with Nimesulide significantly attenuated the …
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Biological role of conceptus derived factors during early pregnancy in ruminants
… conceptus as well as the endometrium synthesize prostaglandins (PGs) via prostaglandin synthase two (PTGS2) and cortisol via hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1). The central hypothesis is that factors from the ovary (progesterone), the conceptus (interferon tau, prostaglandins, and …
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ROLE OF OXYTOCIN AND OXYTOCINASE IN THE MATERNAL RECOGNITION OF PREGNANCY
… expression of both endometrial and luteal prostaglandin E synthase (PTGES). Furthermore, PTGES expression was higher in diestrous, pregnant and oxytocin treated mares, suggesting that prostaglandin E (PGE) may have a luteoprotective role. To further characterize the gene expression during …
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Production of prostaglandin E2 and thromboxane A2 by rat liver macrophages and involvement of nitric oxide and cytokines in mediator pathways under inflammatory conditions
… in the liver. Among them there are prostanoids (prostaglandin (PG) E2 and thromboxane (Tx) A2), cytokines (e.g. interleukin (IL)-1,-6, -10, tumor necrosis factor (TNF) α) and inorganic mediators like nitric oxide (NO). Macrophages-derived products play opposing roles in the development of liver …