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Showing 1 to 20 of 93 for “"prostaglandin E2"”.
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Einschränkung hepatischer Abwehrreaktionen während einer Entzündung durch Prostaglandin E2 über Gs-Protein-gekoppelte Prostaglandin E2-Rezeptoren
… des EP2-R und EP4-R induzieren, wodurch PGE2 cAMP-abhängig die IL-6-stimulierte Bildung des Haupt-Akutphase-Proteins der Ratte, des alpha2-Makroglobulin, durch eine Verringerung der Aktivität des Transkriptionsfaktors STAT3 hemmen konnte. In Kupfferzellen der Ratte und der Maus konnten …
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Modulation der Insulinsignalgebung durch Prostaglandin E2 und Endocannabinoide
… Antwort auf dieses Entzündungsgeschehen wird PGE2 unter anderem von Kupffer Zellen der Leber freigesetzt und kann seine Wirkung über vier PGE2-Rezeptorsubtypen (EP1-EP4) vermitteln. In vorangegangenen Arbeiten konnte gezeigt werden, dass PGE2 in Rattenhepatozyten über den EP3 R ERK1/2-abhängig …
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Localization of Human Prostaglandin E2 Receptors in Polarized Epithelial Cells
… in subcellular localization of the human prostaglandin E2 receptors. The EP receptors are all GPCRs, which differ in their second messenger pathways. The EP3 receptor is unique in that it has eight different isoforms that differ in the lengths of the carboxyl tail. The EP3 isoforms, as …
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Targeting Prostaglandin E2 Receptor EP2 for Treatment of High-Risk Neuroblastoma
<p>Prostaglandin E2 (PGE2) is a predominant proinflammatory regulator that plays pivotal roles in regulating tumor cell proliferation, migration, and invasion. It fosters an inflammation-enriched microenvironment that facilitates angiogenesis and immune evasion. Neuroblastoma (NB) is a lethal …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… pathway which play a key role in synthesising prostaglandin E2 (PGE2) from arachidonic acid. PGE2 has been implicated in preclinical stages of Alzheimer’s disease, where elevated levels of PGE2 in the cerebrospinal fluid can be found, as well as aberrant amyloid processing in experimental …
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The role of nitric oxide and prostaglandin E2 in prolonged hemorrhagic shock
… of NO might be further worsen when coupled with prostaglandin E2, a known vasodilator, in prolong hemorrhagic shock. Nitric oxides being a vasodilator might be responsible for the loss of vascular hyporesponsiveness in the presence of a potent vasoconstrictor, angiotensin II, in our model of …
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Investigating Prostaglandin E2 activation of the p38 pathway of oesophageal squamous cell carcinoma
… In that context, it was postulated that prostaglandin E2 (PGE2), a hormone derived from a main component of maize, continuously triggers activation of proliferation and inflammation pathways. This work aimed at assessing the role of p38, a mitogen-activated protein kinase (MAPK), in the …
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Tumor-induced immunosuppression: Contribution of a high molecular weight inhibitor and Prostaglandin E2
… supernatants. Concentrated supernatants were prostaglandin E₂ (PGE₂)-free and yet inhibited proliferation in the mixed lymphocyte reaction (MLR) and mitogen assays. The high mw inhibitory factor was apparently >67 kd, as shown by S-200 Sephacryl chromatography and gel electrophoresis. …
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PROSTAGLANDIN E2 PATHWAY AS A TARGET TO PREVENT AND TREAT OVARIAN CANCER IN LAYING HENS
Chronic inflammation has been linked to cancer. Prostaglandin E2 (PGE2) is the most pro-inflammatory lipid and one of the downstream products of 2 isoforms of cyclooxygenase (COX) enzymes: COX-1 and COX-2. Although both COX isoforms have similar structure and function, they are encoded by different …
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Effect of Prostaglandin E2 on the Expression of Adhesion Molecules in Mouse Cerebrovascular Endothelial Cells
Prostaglandin E2 (PGE2) is known to be the principal pro-inflammatory prostanoid and play an important role in brain disease through binding to four G protein-coupled receptor (EP1-4). However, there have been contradictory reports on its actions in inflammation processes. For instance, PGE2 …
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Genetic Polymorphism Study of Prostaglandin E2 Receptor Subtype EP4 gene (PTGER4) in Aspirin - Intolerant Urticaria
… 약 어 = viii I. 서 론 = 1 Ⅱ. 재료 및 방법 = 4 A. 프로스타글란딘 E2 수용체(PTGER4)의 단일염기다형성 연관성 연구 = 4 1. 직접염기서열 분석을 이용한 프로스타글란딘 E2 수용체의 단일염기다형성의 조사 = 4 2. 연구 대상 및 표현형 = 5 3. 유전자형 분석 = 5 B. 프로스타글란딘 E2 수용체의 단일염기다형성의 기능적 연구 = 11 1. 세포배양 = 11 2. 역전사 중합효소연쇄반응(RT-PCR)을 이용한 다양한 세포주에서의 PTGER4 유전자의 발현 = 11 3. Promoter …
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Fas ligand expression and tumour immune evasion; the role of prostaglandin E2 and the EP1 receptor
… in colon carcinogenesis, via the production of prostaglandins, in particular PGE2. PGE2 signals through four different receptor subtypes, EP1 – EP4. Thus, the aim of this study was to investigate the effect of targeting the PGE2-FasL signaling pathway. Results: (i) PGE2 induces FasL expression …
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Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
… of cyclooxygenase-2 (COX-2) and COX-2 generated prostaglandin E2 (PGE2) during pancreatic fibrosis. Pancreatic stellate cells (PSC) are the predominant source of extracellular matrix production (ECM), thus being the key players in both diseases. Given this background, the primary objective is to …
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Maternal Exposure to Prostaglandin E2 Affects Hippocampal Synaptic Plasticity in Mice Offspring -A Link to Autism Spectrum Disorder
Prostaglandin E2 (PGE2) is a lipid signaling molecule involved in early healthy brain development. Exposure to environmental risk factors such as air pollutants, infections, and drugs such as acetaminophen during early pregnancy have shown to impact PGE2 levels and have all been linked to Autism …
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Effect of Prostaglandin E2 on Mechanical Stresses Applied by MC3T3-E1 Osteoblast-like Cells on a Soft Hydrogel Substrate
… are sensitive to mechanical stimuli and release Prostaglandin E2 (PGE2) when exposed to a fluid shear stress. The exact mechanism by which these cells sense mechanical stress is not well established. A study of the stresses applied by the osteoblasts, under the influence of PGE2, on a hydrogel …
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Effect of a single intra-articular injection of bupivacaine on synovial fluid prostaglandin E2 concentrations in normal canine stifles
… is unknown, but may involve inflammation. Prostaglandin E2 (PGE2) is an inflammatory mediator and a marker of joint inflammation. The aim of this study was to compare synovial fluid PGE2 concentrations after a single intra-articular injection of bupivacaine with a saline control in normal …
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