Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"prosaposin"”.
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Modelling saposin deficiency in Drosophila: progressive neurodegeneration, storage and physiological decline
… The disorder is caused by mutations in the prosaposin gene, which encodes 4 activator proteins: saposins A - D. Mutations affecting individual saposins lead to different LSDs. Therefore, modelling saposin deficiency in Drosophila provides great scope for understanding childhood …
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IMPROVING GLYCOSYLATION EFFICIENCY IN ESCHERICHIA COLI BY MAMMALIAN-CELL-INSPIRED PROTEIN-PROTEIN INTERACTIONS
… novel model acceptor protein based on the human prosaposin was developed. While the proposed designs were ineffective under the conditions tested, we discovered that fusion proteins of the Campylobacter jejuni PglB were able to improve the expression of challenging acceptor proteins without …
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Repulsive cues and signalling cascades of the axon growth cone
The aim of the work described in this thesis is to investigate the nature and mechanisms of action of repellent cues for growing axons. In particular I try to resolve the controversy in the literature regarding the need for protein synthesis in the growth cone in response to external guidance cues. …