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Showing 1 to 9 of 9 for “"proprotein convertase"”.
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The New Role of Proprotein Convertase Subtilisin/Kexin Type 9: A Connection of Proprotein Convertase Subtilisin/Kexin Type 9, Apolipoprotein B, and Autophagy
… achieved by the uptake via LDL receptor (LDLR). Proprotein convertase subtilisin/kexin type 9 (<em>PCSK9</em>) is a newly discovered gene, playing an important role in LDL metabolism. Gain-of-function mutations of <em>PCSK9</em> lead to hypercholesterolemia and loss-of-function mutations of …
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PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, ATHEROSCLEROSIS AND EXTRACELLULAR VESICLES ¿ EXPERIMENTAL AND CLINICAL EVIDENCE
… are packed into extracellular vesicles (EVs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is expressed and secreted by VSMCs. This study aimed to unravel the role of PCSK9 on VSMCs-derived EVs in terms of content and functionality. EVs were isolated from human VSMCs overexpressing …
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Characterization of PCSK9-mediated LDLR Degradation in Hepatic and Fibroblast Cells
The discovery that proprotein convertase subtilisin/kexin type 9 (PCSK9) mediates degradation of low-density lipoprotein receptors (LDLR) indicates a critical role in LDL metabolism. PCSK9 is a secreted protein that binds to the epidermal growth factor-like (EGF)-A domain of LDLR and directs the …
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Microarray Analysis Identifies Novel Cholesterol Regulated Genes, Including Pcsk9 Which Regulates LDL Receptor Function and LDL Cholesterol Levels
… target genes. One of the down-regulated genes, Proprotein convertase subtilisin kexin 9 (Pcsk9) was cloned from mouse liver. Pcsk9 was found to be synthesized as a pro-form in the endoplasmic reticulum (ER) and expressed as a processed form in the trans-Golgi network. In mice, Pcsk9 was found to …
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The Role of Slow-Twitch Skeletal Muscle in the Musculoskeletal Endocrine Axis
… Dmp1-driven Cre. MBTPS1 is a widely expressed proprotein convertase involved in proprotein processing within the secretory pathway. In bone, MBTPS1 is required for normal skeletal development and mineralization. Ex vivo contractility of cKO EDL and soleus muscles revealed an age-related …
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Characterization of the Non-Proteolytic Mechanism and Cellular Site of Action of PCSK9-Mediated Degradation of the Low-Density Lipoprotein Receptor
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a serine protease that has emerged as a central regulator of plasma low-density lipoprotein cholesterol levels. Here, it is demonstrated that PCSK9 is secreted into the blood and that the secreted PCSK9 binds and degrades LDLRs in liver. To …
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APOE, PCSK9, and CETP genetic variants as potential biomarkers of dyslipidaemia in black South Africans with Type 2 Diabetes Mellitus
… component is evident. Apolipoprotein E (APOE), proprotein convertase subtilisin/kexin type 9 (PCSK9), and cholesteryl ester transfer protein (CETP) are key regulators of plasma cholesterol levels. Thus, genetic variation in the genes coding for these proteins contributes to dyslipidaemia. In …
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Type 2 diabetes mellitus and dyslipidaemia: effects of genetic variation in African populations
… enzymes such as Apolipoprotein E (ApoE) and proprotein convertase subtilisin/kexin type 9 (PCSK9). ApoE and PCSK9 are involved in clearance of lipoproteins and therefore, influence lipid profiles. Association between ApoE and T2DM in cardiovascular diseases have been widely reported. PCSK9 on …
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Channel activating proteases: molecular targets for correction of sodium channel dysfunction in cystic fibrosis airways disease
Cystic fibrosis (CF) is an autosomal recessive disease, caused by mutations in the gene which codes for the CF transmembrane conductance regulator (CFTR). Mutations in CFTR cause multi-organ dysfunction, including in the lungs, pancreas, gastro-intestinal system and the reproductive system. …