Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"proneural genes"”.
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Proneural Genes in Neocortical Development
… development is regulated by both intrinsic proneural genes Neurog2 and Ascl1, and extrinsic signals. However, how these intrinsic factors and extrinsic signals coordinatedly control neural cell fate decisions was not well understood at the start of my studies. Neurog2 and Ascl1 were known to …
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Transcriptional Regulation of Neuronal Fate Specification by Proneural Genes in the Developing Neocortex
… that control the timing of cortical neurogenesis are the proneural basic helix-loop-helix (bHLH) transcription factors encoded by Neurog1, Neurog2, and Ascl1. The activities of these proneural genes are tightly regulated, ensuring that neocortical neurons are born at their correct times …
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The Role of Transcription Factors in Regulating Adult Neurogenesis after Excitotoxic Brain Injury
While compensatory striatal neurogenesis is well documented in many injury models, cells of the correct lineage for endogenous repair are not always regenerated. To understand why, the molecular profile of subventricular zone (SVZ)-derived neural progenitor cells (NPCs), and their response to …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… TIS21 regulates cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors. And In human tissue, BTG2 has a critical role in cancer cell migration and invasion. The matrix metalloproteinases …
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Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
… this thesis I have identified expression of the proneural gene Neurogenin2 (Ngn2) in a restricted pattern in the embryonic VM during mesDA neurogenesis. The protein was expressed in the progenitor population in the ventricular zone but not in mature neurons in the mantle zone. When isolating the …