Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"proneural"”.
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Proneural Genes in Neocortical Development
… development is regulated by both intrinsic proneural genes Neurog2 and Ascl1, and extrinsic signals. However, how these intrinsic factors and extrinsic signals coordinatedly control neural cell fate decisions was not well understood at the start of my studies. Neurog2 and Ascl1 were known to …
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Quantitative analysis of signaling networks in proneural glioblastoma
… in a genetically engineered murine model of proneural GBM, we quantified signaling networks using mass spectrometry. We identified oncogenic signaling associated with the GBM model, such as increased phosphorylation of ERK1/2, P13K, and PDGFRA, relative to murine brain. Phosphorylation of …
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Transcriptional Regulation of Neuronal Fate Specification by Proneural Genes in the Developing Neocortex
… the timing of cortical neurogenesis are the proneural basic helix-loop-helix (bHLH) transcription factors encoded by Neurog1, Neurog2, and Ascl1. The activities of these proneural genes are tightly regulated, ensuring that neocortical neurons are born at their correct times and with their …
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Covalent modification and intrinsic disorder in the stability of the proneural protein Neurogenin 2
Neurogenin 2 (Ngn2) is a basic Helix-Loop-Helix (bHLH) transcription factor regulating differentiation and cell cycle exit in the developing brain. By transcriptional upregulation of a cascade of other bHLH factors, neural progenitor cells exit the cell cycle and differentiate towards a neuronal …
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The Role of the Proneural Transcription Factor ASCL1 in Neuroblastoma Cell Division and Differentiation
Neuroblastoma is the most common solid childhood cancer and typically has a very poor prognosis. Neuroblastoma is a ‘cancer of improper development’ and is thought to arise from sympathetic neuroblast precursors that fail to engage the neuronal differentiation programme; instead they are locked in …
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The Role of Transcription Factors in Regulating Adult Neurogenesis after Excitotoxic Brain Injury
… OPCs were recruited into the lesioned striatum. Proneural genes can repress Olig2 lineage cells, and substantially increase neurogenesis when overexpressed in the adult brain. Proneural Dlx2-GFP and Pax6-GFP retroviruses were injected into the SVZ on the day of lesioning, or two days post lesion …
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Regulation and function of genes involved in drosophila ciliogenesis
Proneural proteins are transcription factors of the bHLH family and have a conserved role in directing neurogenesis from invertebrate to mammals. In Drosophila, proneural proteins are required for early developmental specification of precursor cells of sense organs (SOPs). Despite considerable …
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Unraveling the neurogenin/ngn-1 gene regulatory network of C. elegans using classical genetics and comparative transcriptomics
… neural development, specifically cascades of proneural transcription factors, can better elucidate which genes are most essential in governing early neurogenesis. Neurogenins are a family of such factors that are both sufficient and necessary for the development of neural sub-types in mice, …
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Roles of Neurogenin and Geminin in Vertebrate Neurogensis
… and geminin in vertebrate neurogenesis Proneural basic helix-loop-helix transcription factors regulate cell fate commitment and differentiation in neurogenesis. However, their proneural functions are not well understood, in part due to a lack of information about their target genes. …
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A three-dimensional agent-based model of glioblastoma with applications towards in vitro and in vivo therapy simulation
… of three different subtypes of glioblastoma: proneural, classical, and mesenchymal. The distinct genetic alterations in these subtypes lead to downstream differences in cell migration speed and immune system activation status. Despite these behavioral differences, glioblastomas are treated …
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Function of the forkhead gene fd3F in Drosophila chordotonal neuron differentiation
… early in development by expression of the proneural gene atonal in the proneural cluster and sense organ precursors (SOPs) (Jarman et al., 1993). However little is known about how chordotonal SOP specification is linked to differentiation of Ch organs. fd3F encodes a forkhead transcription …
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TIS21 inhibits cell migration by downregulating expression of matrix metalloproteinases
… TIS21 regulates cell cycle progression and proneural genes expression by acting as a transcription coregulator that enhances or inhibits the activity of transcription factors. And In human tissue, BTG2 has a critical role in cancer cell migration and invasion. The matrix metalloproteinases …
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Characterization of split ends function during Drosophila eye development
… for establishing and refining the expression of proneural Atonal (Ato). Ato promotes the EGFR pathway's reiterative signaling for progressive and sequential recruitment of cells within each ommatidial facet of the eye.
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Molecular Consequences of High Taz Expression In Gliomas
… transcriptional subtypes, the most notable being Proneural (PN) and Mesenchymal (MES) classes. The most aggressive forms of the disease have a Mesenchymal expression signature, with reported PN-to-MES transition occurring with tumor progression. Master regulatory analysis has identified the …
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Role of the ubiquitin-proteasome pathway in the inner ear : identification of an E3 ubiquitin ligase for Atoh1
Atoh1, the proneural basic-helix-loop-helix transcription factor, is critical for the differentiation of inner ear hair cells. Hair cells do not develop in mice that lack Atoh1, and overexpression of the transcription factor in embryonic ears induces differentiation of extra hair cells. The level …
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Validating ngn-1 transcriptome targets in C. elegans
… that <em>ngn-1</em> functions broadly as a proneural transcription factor during C. elegans neurogenesis.</p>
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Characterization of Neural Stem Cells Using the Nestin Enhancer
… in ectopic sites. These results indicate that proneural ngn1 promotes the nestin expression through a E-box located in the nestin second intron. Finally, we also performed microarray to characterize the GFP positive and negative cells in nestin-GFP tg mice neurosphere. The microarray profile …
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Malignant Gliomas Originate From Neural Stem/Progenitor Cells and Are Maintained By Cancer Stem Cells
… similarity with human GBM and showed a generally proneural marker gene expression profile. We also found that tumors from the same initial genetic mutations can be further divided into several subtypes. Previous studies suggested a neural stem/progenitor cell (NSC) origin for gliomas, however …
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Generation of cells for cell-replacement therapy: Specification of neural precursors in vivo and in neural stem cell cultures
… of this thesis has focused on the role of the proneural gene Neurogenin2 in specification of the midbrain dopaminergic (mesDA) neurons, the cell population that degenerate in Parkinson’s disease. Additionally, we have studied to what extent neural stem cells isolated from the developing brain …
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Context-dependent activity of a pioneer transcription factor, ASCL1, in early development
… to address these unanswered questions, using the proneural ASCL1 as a model pioneer TF. Using a mouse embryonic stem cell line with inducible ASCL1 activity, I showed that cells undergo ASCL1-directed neuronal differentiation after priming towards a neuroectoderm identity. However, pluripotent …
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