Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"promoter mutations"”.
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Adenylyl Cyclase 2 Selectively Regulates IL-6 Expression in Human Bronchial Smooth Muscle Cells
… kinase A (PKA) assumed the larger role. IL-6 promoter mutations demonstrated that activator protein 1 (AP-1) and cAMP responsive element (CRE) transcription sites were required for cAMP mediated induction. Our findings indicate that AC2 participates in a cAMP-signaling compartment that …
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Circulating tumour DNA: A non-invasive biomarker for melanoma
… Notably, telomerase reverse transcriptase (TERT) promoter mutations are present in 50-70% of melanomas and confer a significantly poorer prognosis if found concurrently with BRAF or NRAS mutations relative to the occurrence of each mutation alone. Thus, the ability to monitor patients at all …
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Characterizing and targeting the genomic consequences of ATRX deficiency in glioma
… stress and genomic instability. These mutations are mutually exclusive with TERT promoter mutations, promoting the alternative lengthening of telomeres (ALT) pathway as a telomere maintenance mechanism in ATRX-deficient glioma. Recently, a class of agents known as G4 stabilizers …
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An Assessment of Universal Tumour Associated Antigens in Primary Liver Neoplasms
… study be increased. Genetic alterations in the promoter sequences were amplified and sequenced using DNA from archived samples. Attempts to quantify the transcribed component which have been locked away in tiny exosomes (which lack degradation enzymes) were made using a quantitative polymerase …
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Dissecting the genomic and epigenomic alterations underlying glioblastoma
… a lack of recurrent non-coding somatic small mutations (SSMs) apart from TERT promoter mutations. We identified loci under putative selection for SV recurrence, including those harbouring focal amplications and deletions, associated with complex SVs such as extrachromosomal DNA (ecDNA) and …
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Molecular Characterization of Fluoroquinolone Resistance in Streptococcus pneumoniae
… changes in fluoroquinolone susceptibility with mutations in the QRDRs, examine the role of efflux using phenotypic tests, and investigate the expression of several putative efflux pumps. The newer fluoroquinolone moxifloxacin was more active in vitro against S. pneumoniae than ciprofloxacin and …
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Interaction of Bacteriophage Mu Middle Transcription Activator Protein Mor with Promoter DNA
… middle and late. Transcription from the middle promoter Pm requires the 129-amino acid transcriptional activator Mor, a product of early transcription, and the Escherichia coli RNA polymerase. The Pm promoter has a recognizable -10 hexamer but lacks a -35 hexamer. Mor binds as a dimer to an …