Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"promoter methylation"”.
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Characterization of Glucocorticoid Receptor Promoter Methylation in Breast Cancer
… can affect epigenetic programming of GR, and methylation of the GR promoter has been reported in colorectal tumourigenesis. Decreased GR expression has also been observed in breast cancer. In addition, it has been previously demonstrated that unliganded GR can serve as a direct activator of …
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Clinical importance of microsatellite instability and promoter methylation of DNA in colorectal cancer // Клинично значение на микросателитната нестабилност и промоторното метилиране на ДНК при колоректален карцином
Проучват се проспективно 189 пациента с колоректален карцином (КРК), от които 98 българи и 81 германци. Събрани са данни относно фамилната обремененост с карцином, локализацията на КРК по хода на дебелото черво, хистологията и стадия по TNM класификацията. При 82 пациенти е проследена 5 г. …
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Identifizierung und Charakterisierung von neuen DNA-Methylierungs-Biomarkern für das humane Mammakarzinom
… benefit of a cancer patient. Since aberrant DNA methylation is essentially involved in tumorigenesis, this alteration may provide a rich source of such molecular biomarkers. In this study, six genes were analyzed for a potential utility as a DNA methylation biomarker in human breast cancer. Five …
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Epigenetic Changes in the Innate Response of Gingival Epithelium
In this study we showed TLR2 CpG promoter methylation in periodontitis affected human gingival tissues and in primary human gingival epithelial cells chronically stimulated with P. gingivalis that may instigate epithelial dysbiosis that may create a unique pathogen niche in the gingival crevice and …
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Regulation of the Glucocorticoid Receptor Promoter and Its Prognostic Value in Tamoxifen-Treated ER+ Breast Cancer
… poor outcome in tamoxifen-treated patients. GR promoter methylation occurs frequently in ER+ tumors and coincides with particularly low GR expression. To investigate GR methylation as a potential biomarker, we developed a targeted multiplex bisulfite sequencing assay to detect promoter …
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ROLE OF SPARC IN DORMANCY OF PROSTATE CANCER IN THE BONE
… epigenetically silenced in Aggressive cells by promoter methylation, but the 5-Azacytidine treatment reactivated the expression. Furthermore, high SPARC promoter methylation negatively correlated with disease-free survival of prostate cancer patients. We also found that the COX2 inhibitor, …
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Integrative Genetic and Epigenetic Studies to Identify Prostate Cancer Genes at Chromosomal 8p
… epigenetic methods. Following the pilot global methylation study, we found three candidate genes with promoter hypermethylation within these three regions. Bisulfite sequencing verified TNFRSF10C promoter was differentially methylated in 46 out of 59 (78%) tumor samples compared to paired normal …
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CANCER-RELATED GENE REGULATION MECHANISMS
… factor activity and modification of promoter functions are therefore important changes in the development of cancer. In the first paper a bioinformatical method is developed that identify transcription factors important for a given tumor type. The basic assumption is that genes that …
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Cxcr2 Expression In Tumor Cells Is A Poor Prognostic Factor and Promotes Invasion and Metastasis In Lung Adenocarcinoma
… factor inhibition (i.e., gefitinib). We studied promoter methylation in 70 human non-small cell lung cancer cell lines and discovered that <em>CXCL5</em> was regulated by promoter methylation. We concluded that the <em>CXCR2 </em>axis may be an important target in smoking-related lung …
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Prediction of Dna Methylation Based On Genomic Architecture and Applications of Positional Weight Matrices
… role in the suppression and promotion of DNA methylation. In our investigation we found a high rate of SINE and LINEs retrotransposon elements near the transcription start site of unmethylated genes when compared to methylated genes. The presence of these elements were positively associated …
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Dietary Soy Protein Isoflavonoid Effects on the Reproductive Tract of the Nonhuman Primate and Neoplastic Human Prostate Gland
… prostate cancer. We hypothesized that ERβ DNA promoter methylation would decrease in prostate cancer with soy isoflavonoid treatment and this would result in an increase in ERβ expression. DNA promoter methylation density of a gene is inversely correlated with the gene’s transcription and …
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Effects of arsenic and UVB radiation on induction of cyclin D1 in human keratinocytes.
… indicates that both arsenic and UVB affect promoter activity in various ways, including methylation. We undertook to examine the effects of arsenite and UVB on activation of the cyclin D1 promoter related to changes in promoter methylation. While data had been inconclusive in identifying …
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The Epigenetics of Small Cell Prostate Cancer
… Interestingly, we observed a low frequency of AR promoter methylation found in samples that lacked AR expression despite previous publications, which led to further analysis of possible silencing mechanisms. Using ChIP-qPCR, we found that the AR promoter is enriched in silencing histone …
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A clinicopathological and molecular genetic analysis of low-grade glioma in adults
… such as IDH1 and IDH2 mutation analysis, MGMT methylation analysis, copy number analysis using array comparative genomic hybridisation and identification of differentially expressed miRNAs using miRNA microarray analysis. IDH1 mutation was present at a frequency of 71% in low grade glioma and …
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Analysis of methylation status of CGB genes in common nontrophoblastic cancer
… factors AP2α, SP1, OCT3/4 and possibly DNA methylation. DNA methylation is a repressive mark found in cytosines in DNA. The aim of this study is to investigate the role of DNA methylation in relation to CGB3-9 genes activation and hCG/hCGβ production in non-trophoblastic cancer cell lines. …
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Consequences of telomerase inhibition and telomere dysfunction in BRCA1 mutant cancer cells
… ovarian cancers, and the gene is silenced via promoter methylation and loss of heterozygosity in a proportion of sporadic breast and ovarian cancers. The objective of this study was to determine whether GRN163L, a telomerase inhibitor, currently in clinical trials for the treatment of cancer, …
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Integrative network modeling of large multidimensional cancer datasets
… the model also predicted that Annexin A2 (ANXA2) promoter methylation and mRNA expression were linked to the signature target genes of the clinically aggressive mesenchymal molecular subtype. Our findings were validated by knockdown of ANXA2 in glioblastoma-derived cell cultures. Paper III …
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The Role of the Methyl DNA Binding Domain Protein 2 (MBD2) in Breast Cancer
… of epigenetic information encoded in cytosine methylation. Their ability to translate DNA methylation into local transcriptional repression has sparked interest in the role of Methyl-Binding Domain Proteins (MBDs) in cancer, where repatterning of CpG methylation is common. In this dissertation …
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REDEFINING PROMOTER DNA METHYLATION CHANGE IN CANCER
Promoter DNA methylation has been recognized for decades as one of the major mechanisms of epigenetic gene regulation and has consistently been found to be perturbed during cancer development. However, among the many genomic regions that have been found to display altered methylation in different …
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Expression Analysis and Stem Cell Engineering
… allows for a degree of multiplexing. Second, DNA methylation was explored as a tool to measure cell fate as ES cells are differentiated into neural cells. We tested the hypothesis that promoter DNA methylation correlates to gene silencing. Promoter methylation of a pluripotency and neural fate …
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