Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"promoter hypermethylation"”.
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Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia
Promoter hypermethylation mediated gene silencing is a frequent epigenetic finding in many cancers that affects genes known to have important roles in several aspects of cell biology. Hematological malignancies have been reported to harbor multiple genes aberrantly silenced by promoter …
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Zur epigenetischen Inaktivierung der Wnt-Antagonisten SFRP-1, -2, -4 und -5 bei der Akuten Myeloischen Leukämie
… gene expression by aberrant CpG methylation in promoter regions is an established epigenetic principle in carcinogenesis. The Wnt signaling pathway plays a key role in cell proliferation as well as differentiation and has been shown to be important for normal hematopoiesis. The family of …
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Mismatch Repair Deficient Tumors Lacking Known Sporadic Causes: Are They All Due to Lynch Syndrome?
… (EC) cancers in the absence of <em>MLH1 </em>promoter hypermethylation and <em>BRAF</em> mutations are suggestive of Lynch syndrome (LS). Positive germline genetic test results confirm LS. It is unclear if individuals with MMRD tumors but no identified germline mutation or sporadic cause …
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Micrornas in Breast Cancer Metastasis: Molecular Regulation of Endothelial Recruitment by Cancer Cells & Regulation of Metastasis Suppressor Micrornas
… undergoes both genetic deletion and epigenetic promoter hypermethylation in metastatic derivatives obtained from independent patients' tumours. Additionally, matched primary tumour-metastases pairs revealed the silencing of miR-335 expression to occur at least partially through genetic deletion. …
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Multigenerational Neurobehavioural and Reproductive Toxicity of Arsenic in Zebrafish (Danio rerio)
… of drd1, mao, and bdnf in the brain. Promoter hypermethylation of these genes across F0 to F2 generations provided mechanistic evidence for epigenetic inheritance of arsenic-induced neurotoxicity. In Chapter 4, the sex-specific reproductive and developmental toxicity of chronic dietary …
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Hypermethylierung-assoziierte Dysregulation der WNT-Antagonisten SFRP 1, 2, 4 und 5 beim Multiplen Myelom
… changes, especially DNA methylation affecting promoter-associated CpG islands, play an important role in the pathogenesis of hematopoietic malignancies. In this study, we detected simultaneous hypermethylation of multiple WNT inhibitors in both MM cell lines and primary samples from patients …
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Integrative Genetic and Epigenetic Studies to Identify Prostate Cancer Genes at Chromosomal 8p
… study, we found three candidate genes with promoter hypermethylation within these three regions. Bisulfite sequencing verified TNFRSF10C promoter was differentially methylated in 46 out of 59 (78%) tumor samples compared to paired normal samples. And this gene was hemizygously deleted in 44 …
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Investigating the molecular dynamics of gene re-silencing following treatment with epigenetic therapies
Aberrant transcriptional silencing of genes by promoter hypermethylation is an important mechanism of tumour suppressor gene (TSG) inactivation in cancer. DNA hypomethylating agents such as 5-Aza-2’deoxycytidine (5-Aza-dC) are approved for the treatment of myelodysplastic syndrome and show promise …
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Regulation of RUNX3 in gastric and breast cancer
… of cytoplasmic mislocalization as well as promoter hypermethylation. Recent studies in our lab have shown that RUNX3 knockout mice have an approximate 20% increased chance of ii developing breast cancer compared to WT mice. At the same time, MCF7 cells expressing RUNX3 resulted in smaller …
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ZNF300 may influence the metastatic properties in pancreatic ductal adenocarcinoma
Aberrant DNA methylation of promoter CpG islands (CGI) is a contributing factor that facilitates the dysregulation of gene expression to promote the tumorigenesis of pancreatic ductal adenocarcinoma (PDAC). Moreover, due to the overwhelming number of PDAC patients presented with metastasis at the …
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Development of novel RNA- and protein-based cancer therapeutics by either silencing of potential oncogenes or active restoration of a tumor suppressor gene
… Hodgkin lymphoma-derived tumor cells by DNA promoter hypermethylation and that receptor-specific targeting of those cells with a constitutively-active version of DAPK2 fused to the CD30 ligand can restore this kinase activity and induce cell death in vitro and in vivo. For this purpose a …
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Genistein suppresses colon cancer metastasis through epigenetic regulations
… the silencing of NDRG1 in SW620 was not due to promoter hypermethylation. Chromatin immunoprecipitation revealed gene-wide decrease in histone H4 acetylation (H4Ac) and increase in phosphorylated histone H3 serine 10 (pH3S10) at the NDRG1 promoter in SW620. Meanwhile, the NDRG1 coding region …