Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"prolines"”.
-
Enantioselective synthesis of alkenyl aziridine carboxylates and 4-phenylsulfenyl prolines
Chiral cyclic and acyclic allyl aminosulfoxonium ylides have been generated from aminosulfoxonium-substituted gamma,delta-unsaturated alpha-amino acids (method A) and 1-alkenyl aminosulfoxonium salts (method B) upon treatment with DBU. Their application to the asymmetric aziridination of …
-
Polyglutamine monomer structure and its implications for molecular self-assembly
… placed on the peptide backbone by inserted prolines, which in tum confines the peptide to native coil structure, discouraging transition towards the ~sheet structure required for aggregation. Such knowledge could prove quite useful to the design of future treatments for Huntington's and …
-
Structural and functional studies of sodium/dicarboxylate cotransporters
… for substrate binding. In this study, conserved prolines from TM 7 and 10 were mutated to alanine and glycine to understand structural as well as functional importance of these residues. Alanine is a strong alpha-helix former and is less flexible whereas glycine, with no side chain, is a strong …
-
Stereochemical aspects of virginiamycin biosynthesis: biosynthesis of antibiotic A33853
… unit and it was shown that both (R) and (S) prolines were incorporated into the dehydroproline unit. (2S,3R)-[3-³H] proline was synthesized and upon incorporation lost the (3-³H) label as evidence of stereochemical control in the formation of the dehydroproline unit from a saturated …
-
Experimental and Computational Dynamics of an Aminoacyl-tRNA Synthetase System
… for structuring the zinc binding knuckle. Eight prolines are found in the CP domain which were individually mutated to alanine. Circular dichroism, binding affinity, and steady-state kinetics were evaluated to determine how the CP domain variants affect the structure and function of the zinc …
-
Intrinsically Disordered Protein Polymer Libraries as Tools to Understand Protein Hydrophobicity
… repetitive biopolymers that, when enriched with prolines, glycines, and aliphatic amino acids, have observable lower critical solution temperature (LCST) phase transition behavior at physiologically relevant temperature and concentration ranges. This behavior is a striking feature of disordered …
-
Biochemical Characterization of Two Aminopeptidases Involved in Hemoglobin Catabolism in the Food Vacuole of Plasmodium falciparum
… the N-termini of peptides containing penultimate prolines. PfA-M1 is a member of the expansive M1 family of proteases and exhibits a broad specificity towards substrates. The two enzymes are ubiquitous, found in organisms across all kingdoms of life. Their presence in an acidic environment is …
-
Structure determination of proteins and peptides in solution: simulation, chirality and NMR studies
… structure. This is due to the presence of prolines, histidines and especially tyrosines, which form a hydrogen bond network in the hexarepeat region, only possible in the avian protein, and thus probably hampering the aggregation.
-
Asymmetrische Synthese 3-substituierter 4-Methylenproline und Untersuchungen zur Metathese mit vinylischen Sulfoximinen
… synthesis of 3-substituted 4-methylene prolines was developed. (S)-N,S-dimethyl-S-phenylsulfoximine was tansformed via an addition, elimination, isomerization route (AEI-route) into the corresponding mixture of E and Z allylic sulfoximines. This conversion yields in all cases more than …
-
Receptor- G Protein Interactions in the Visual System: A Study of Structures and Mechanisms That Couple the Cytoplasmic Surface of Rhodopsin to the Nucleotide-Binding Pocket of Transducin
… as did substitution of α5 residues with prolines. These results provided evidence that R* induced nucleotide exchange primarily by perturbing the structure of buried residues on α5 and not by opening the interdomain cleft. Structural analysis and biochemical data were used to propose a …
-
Atomistic Investigation of Nucleosomal H3 Histone Tail in Unmodified and Epigenetically Modified States
… H3 tail showed that the prolines function as segmental dividers or hinges of the H3 tail. We show that Segment I is more dynamic than Segments II and III, and Segment I makes multiple transient contacts with the DNA. The PTMs affect the tail'sII dynamics to different …
-
Development of New Synthetic Approaches to Biologically-Active Peptides
… molecules was investigated. Fluorinated prolines were used to explore protein-protein interactions and dynamics, specifically to study the peptidyl-prolyl isomerase cyclophilin D (CypD). First, short substrates were synthesised, including a section of Bcl2 (8 amino acids) and F0F1 ATPase …
-
Development of an Improved Proteogenomics Solution to Identify Comprehensive Catalogues of Novel Small Proteins in Prokaryotes
… proteogenomics workflow. The enrichment of prolines in the sequences of these proteins demonstrates the benefit of direct sequencing for the identification of proteins that are difficult to identify with a standard trypsin digestion and three novel small proteins predicted to form an operon …