Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"proline-rich tyrosine kinase 2"”.
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THE ROLE OF THE PROLINE-RICH TYROSINE KINASE 2 PROTEIN IN THE REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALLING
… involved in their signalling. We have identified proline-rich tyrosine kinase 2 (Pyk2) as an mGluRl/5 interacting protein, and our objective was to investigate its contribution to the downstream activation of extracellular signal-regulated kinases (ERKs) by Group I mGluRs. In HEK 293 cells, ERK1/2 …
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Regulation of osteoblast activity by Pyk2-targeted approaches
… formation are not completely understood. The proline-rich tyrosine kinase 2 (Pyk2) is important for osteoblast (OB) activity and bone formation. However, female mice lacking Pyk2 (Pyk2-KO) exhibit elevated bone volume/total volume. Previously, our laboratory found ovariectomized Pyk2-KO mice …
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Roles of GSK-3beta and PYK2 signaling pathways in synaptic plasticity
… of two signaling pathways, glycogen synthase kinase 3 beta (GSK- 3beta) and proline-rich tyrosine kinase 2 (PYK2), in LTD at rat hippocampal synapses. GSK-3beta, a serine/threonine kinase implicated in the pathophysiology of schizophrenia, mood disorders, and Alzheimer's disease, is known to …
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Calcium Remodeling through Different Signaling Pathways in Heart Failure: Arrhythmogenesis Studies of Pyk2, Dystrophin, and β-adrenergic Receptor Signaling
… β adrenergic receptor signaling pathway.</p><p>Proline-rich tyrosine kinase 2: Pyk2) is a non-receptor protein kinase regulated by intracellular Ca. It mediates a typical stress activated signaling pathways along with c-Src, P38 MAPK and regulates a broad range of key biological responses. By …