Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"proline-rich domain"”.
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The Evolution of Platelet Responses to Collagen Under Conditions of Hemodynamic Flow
… do not express GPVI. Here we show that the GPVI proline-rich domain accelerates GPVI signaling kinetics and is required for maximal adhesion to collagen under flow. The proline-rich domain accelerates signaling through binding and directly activating the Src-family kinase Lyn. Chicken …
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Analysis of the Interaction and Functional Determinants of Arc and Its Regulation of Dynamin
… binding studies show Arc interacts with the proline-rich domain of dynamin and not the pleckstrin homology domain. All together, these results provide a mechanism to explain the previously reported role of Arc in glutamate receptor internalization.
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Characterization of a Putative Activation Domain in the Hulk Gene Family
… proteins encoded by these genes share conserved domain structures including a proline-rich region (PRR) in the carboxyl-terminus. Based on sequence analysis and the presence of a proline-rich domain, it has been suggested that the HULKs are putative transcription factors in which HUA2 is known to …
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Principles of COPII Coat Assembly
… between Sec23 and the Sec31 disordered proline-rich domain. The Sec31 unstructured domain comprises known Sec23 binding sites, namely the ‘active fragment’ and short PPP motifs. My data demonstrate that although these interfaces are important for the inner/outer layer interaction, they …
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Biochemical Reconstitution and Functional Characterization of the WAVE Regulatory Complex
Members of the Wiskott-Aldrich syndrome protein (WASP) family (WASP, N-WASP, WAVE 1-3) have a central role in the transmission of the extracellular signals to the actin cytoskeleton. These proteins use their C-terminal VCA domain to stimulate the actin-nucleating activity of Arp2/3 complex in …
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Regulation of The Escrt Function of Alix
… interaction between N-terminal Bro1 domain and C-terminal PRD (proline-rich domain), leading to a closed conformation of ALIX that cannot interact with CHMP4. This predicts that ALIX involvement in ESCRT-mediated processes requires an activation step that relieves the intramolecular …
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Eukaryotic Transcriptional Activation Mechanism: Protein-Protein Interactions
… the function of distinct kinds of activation domains in yeast and human. The results showed that the proline-rich activation domain of CTF1 can, like acidic activation domains, activate transcription in yeast and human. Based on this, I compared the activation pathways by acidic and …
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Diversity in APOBEC3 and CCR5 host genes and HIV-1 in a South African population
… all samples except in 4 samples. The functional domain and motifs, such as Zn binding motifs, proline-rich domain, human casein kinase, and the N and C-terminal CBF interaction site were highly conserved. APOBEC binding motifs and the nuclear localization signal were less conserved in the South …