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Showing 1 to 20 of 345 for “"proline"”.
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Genetic dissection of proline transport by Salmonella typhimurium
… the molecular mechanism of substrate transport. Proline transport by Salmonella typhimurium is a good model system for studying the molecular mechanism of ion-driven transport systems. The putP gene encodes proline permease, a sodium/proline symport system. In order to identify the active site of …
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Proline-rich acidic protein 1 in Life and Death
The Proline-rich acidic protein (PRAP1) was initially identified as a gene that was differentially expressed in pregnant mouse uterus. The rat and human homologues were subsequently identified and found to be expressed abundantly in the gastrointestinal tract. This thesis describes the …
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Structural, biochemical, and inhibition studies of proline biosynthetic enzymes
… reductase (PYCR) is the final enzyme in proline biosynthesis, catalyzing the NAD(P)H-dependent reduction of [Delta]1-pyrroline-5-carboxylate (P5C) to proline. Mutations in the PYCR1 gene alter mitochondrial function and cause the connective tissue disorder cutis laxa. Furthermore, PYCR1 …
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Biophysical Characterization Of A Proline Mutant Of Neural Cadherin
… difference in the strand swapped interface is a proline in ncad and a glutamate in ecad in position 16. Our hypothesis is that the slow kinetics of dimer disassembly of ncad is due to the steric restrictions of proline in position 16 of ncad. The purpose of this research is to mutate the proline, …
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The Metabolism of Proline, and The Isolation and Characterization of Proline-Dehydrogenase and Pyrroline-5-Carboxylate-Reductase From Pumpkin (Cucurbita Moschata, Poir.) Seedlings
Made available in DSpace on 2015-05-14T14:56:20Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7414607.PDF: 3578860 bytes, checksum: 9c58d0cc1d482d09db944521c29b84fc (MD5) Previous issue date: 1974
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Structural Analysis of STE20-Related Proline-Alanine-Rich Kinase (SPAK)
Ste20-related proline-alanine-rich kinase (SPAK) is a kinase that regulates ion cotransporters including KCC, NKCC1, NKCC2 and NCC. Recently, SPAK was identified as a target regulated by the WNK (With No lysine (K)) family of protein kinases. Overexpression of WNK1 has been associated to a …
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The Effect of L-Proline on Two Recombinant AMPA Glutamate Receptors
<p>L-proline is a non-essential amino acid and one of the major amino acid constituents of extracellular fluid. Specific mutations in genes that control proline metabolism lead to hyperprolinemia which is characterized by an increase in the level of blood and cerebrospinal fluid concentration of …
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Synthesis and catalytic testing of a proline functionalized amphiphilic block copolymer
… a hydrophobic O-methacryloyl-trans-4- hydroxy-L-proline and methyl methacrylate end and a hydrophilic acrylic acid end was characterized. The polymer was tested as an asymmetric catalyst for an aldol reaction in aqueous conditions. The polymer was able to successfully stereoselectively catalyze …
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Structure, function, and evolution of proline transport systems in Salmonella typhimurium
… and function of the substrate binding site of proline permease and the evolution of a new proline transport system.
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Coordinate regulation of Vegf signalling genes by the proline rich homeodomain protein
PRH is a transcriptional repressor that regulates development of the haematopoietic and vascular systems. VEGF is a mitogen that stimulates cell survival via cell surface receptors including VEGFR1 and VEGFR2. This thesis identifies Vegf, Vegfr1, and Vegfr2 as bona fide PRH target genes and shows …
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Protein -Dna Interactions Required for Regulation of the Proline Utilization Operon in Salmonella
… effects of the mutations in vivo was analyzed by proline dehydrogenase assays and beta-galactosidase assays using a putA::MudJ fusion downstream of each of the put control region mutant. Although the mutations isolated in the put control region are defective in PutA binding in vitro, they do not …
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Enantio-Selective Mechanism of the Poly-Proline Chiral Stationary Phase: a Molecular Dynamics Study
Poly-proline-based chiral stationary phases are relatively new stationary phases and have shown to be competitive to other commercially available chiral stationary phases for high performance liquid chromatography (HPLC). The conformational studies, solvation properties and enantio-selective …
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Targeting Mitochondrial Proline Dehydrogenase (PRODH) with a Suicide Inhibitor as a Novel Anticancer Strategy
<p>Proline dehydrogenase (PRODH) is a p53-inducible inner mitochondrial membrane protein linked to electron transport and capable of generating mitochondrial glutamate and intracellular ATP, especially under cellular stress conditions. Among a panel of 51 human breast cancer cell lines, PRODH and …
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Variation in proline-rich proteins and DNA methylation patterns in soybean seed color isolines
The I locus controls pattern expression of anthocyanin pigments in soybean seed coats. Using isolines of soybean cultivars varying only at the I locus, a seed coat cell wall protein that is affected by seed coat color was identified. A cDNA library was constructed using messenger RNA isolated from …
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