Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"proliferating cells"”.
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Diverse Roles Of Nuclear Intermediate Filaments In Proliferating Cells
… an adult. DNA damage can arrest some embryonic cells but genetic instability is a hallmark of cancer. This thesis studies the contrasting role of two nuclear intermediate filaments - Lamin A and Lamin B1 in the proliferating cells of embryonic hearts and cancer. Lamin B1 is upregulated together …
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The role of respiration in supporting cell proliferation
Compared to non-proliferating cells, proliferating cells such as cancer cells have additional metabolic requirements for generating biomass. However, despite these additional requirements the components of the mammalian metabolic network in both proliferating and non-proliferating cells are largely …
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Liver fluke development: a target for parasite control?
… have identified a population of proliferative cells within Fasciola hepatica (Fasciola proliferative cellsFPCs) that resemble neoblast-stem cells, both morphologically and behaviourally. These cells are the only proliferating cells in Fasciola hepatica and can be localised using thymidine …
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Bioenergetics and metabolism of eukaryotic cell proliferation
… accumulation and proliferation in eukaryotic cells. We first determined that the underlying mechanism behind why rapidly proliferating cells preferentially ferment the terminal glycolytic product pyruvate is due to an intrinsic deficiency of respiration to regenerate electron acceptors. We …
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Developmental Appearance of Phosphorylated Intermediate Filaments in Nuclei of Glioma and Neuroblastoma Cells
… skeleton in the nucleus of eukaryotic cells, termed the nucleoskeleton, is only vaguely known. Investigations into the role of intermediate filaments (IF) in the nucleus have primarily focused upon lamins, however some studies have suggested that there may be a role for non-lamin …
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Artemis Interacts With The Cul4A Ubiquitin E3 Ligase Complex and Regulates The Cell Cycle Progression
… critical for cell cycle progression in normally proliferating cells and in response to serum withdrawal. Finally, I provide evidence showing that Artemis may be also a part of other Cullin-based E3 ligase complexes, and it has a role in controlling p27 levels in response to different cellular …
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Organ and primary culture of medaka (Oryzias latipes) testis: Test systems for the analysis of cell proliferation and differentiation
In cultured medaka testis fragments, cells remained viable for the entire culture period (17h), and spermatids that developed from spermatocytes were viable and motile. Primary cultures were characterized over a period of two days with respect to cell viability and the distribution of adherent and …
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Defining the contributors to mammalian cell mass
… demands. Metabolic alterations associated with proliferating cells have been characterized, and increasing research interest seeks to provide mechanistic and teleological insight into these metabolic alterations. The following dissertation provides a framework for understanding how proliferating …
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The Impact of Opioids and Opiates on Adult Hippocampal Neurogenesis
… proliferation and survival of progenitor cells in the adult rat and mouse hippocampus. Here, I show that endogenous opioids may act through the mu opioid receptor (MOR) to similarly decrease survival of new hippocampal neurons. An exon 1 MOR knockout mouse showed increased survival of new …
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Cellular and genetic mechanisms of new tissue production in the regenerating planarian Schmidtea mediterranea
… for studies of regenerative biology in which proliferating cells known as "neoblasts" provide the source of new cellular material for regeneration. Stem cells that might be present within the neoblast population, however, have not yet been defined. Such cells could therefore be either …
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The Role of Insulin-Like Growth Factor-I in Myeloid Cell Differentiation
… are specifically induced as myeloid progenitor cells undergo differentiation toward macrophages. However, the potential role of IGF-I in myeloid cell differentiation has not yet been investigated. The data in this thesis demonstrate that IGF-I combined with either RA or vitamin D$\sb3$ enhances …
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Negative Regulation of the Hippo Pathway by the Ajuba LIM Proteins
… inactivation of YAP only in low density, proliferating cells, suggesting that the Ajuba LIM proteins function to keep the Hippo pathway off in contexts where cell proliferation is needed, but are unable to prevent activation of the pathway by signals such as cell density. We demonstrate …
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Transcription Regulates Biased Mitochondrial DNA Inheritance
… making mtDNA of critical importance to cells. However, mtDNA inheritance in proliferating cells is not fully understood. There is a set of mtDNA mutants in Saccharomyces cerevisiae, called hypersuppressives, that exhibit biased inheritance when competed with wild-type (rho+) mtDNA. A …
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Effect of probiotics or high incubation temperature on gene expression and cell organization of the small intestine and yolk sac of chicks
… villi with tight junctions between adjacent cells. Probiotics have been reported to improve chicken growth performance and gut health including promotion of intestinal morphology. However, there are few studies that show the effect of probiotics on ontogeny of intestinal epithelial cells and …
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Viral Inhibition of Mammalian Cell DNA Synthesis
<p>Eukaryotic cells replicate their DNA during a defined time period in the interphase between mitoses. Non-proliferating cells are generally found to be blocked in interphase prior to the DNA-synthetic period. It therefore appears that the control of cellular proliferation may be intimately …
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Regulation of neuronal genomic integrity through histone deacetylase cooperativity
… preserving genomic integrity are well defined in proliferating cells, corresponding pathways in postmitotic neurons remain poorly understood. In this report, I characterize the functions of two lysine deacetylases, SIRT1 and HDAC1, in the neuronal response to DNA double strand breaks (DSBs). Both …
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Regulation of Oligodendrogenesis in a Rat Contusive Spinal Cord Injury
… traumatic spinal cord injury (SCI). Although proliferating glial progenitor cells (GPCs) are present in the lesioned spinal cord, spontaneous remyelination is extremely limited. The failure of remyelination after SCI may be due to inadequate signaling to generate sufficient OLs from GPCs. In …
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NON-GENETIC MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA
… leukemic drugs. Drug resistance in leukemic cells has been associated with intratumoral heterogeneity, among which quiescence, specifically, is considered a key factor for cell survival. Experimental evidence collected both from patients and model systems suggests that relapse is due to rare …
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Metabolic regulation of mammalian cell growth and proliferation
Proliferation requires that cells acquire sufficient biomass to produce two daughter cells. To accomplish this, cells must utilize available nutrients to generate new components of cell mass, including proteins, lipids, and nucleic acids. In addition, cells must coordinate biosynthesis and …
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Post-genomic studies on the neuropeptide signalling system of Juvenile <i>Fasciola hepatica</i>
… Combining this staining with the localisation of proliferating cells, or neoblasts, supports a potential link between NPF signalling and neoblasts. Significant improvements have been made to an existing chromogenic in situ hybridization (CISH) protocol to include a more sensitive fluorescent …
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