Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"projection neurons"”.
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Spatial, temporal, and circuit-specific activation patterns of basolateral amygdala projection neurons during stress
… patterns of basolateral amygdala (BLA) projection neurons during exposure to acute stress. Additionally, we explicitly tested the role of the BLA in activation of the HPA axis, as this remains a poorly understood process. Chapter 1 describes how the BLA is anatomically well-situated for …
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Processing of plant-associated odors by a subset of projection neurons in the antennal lobe of the female moth, Manduca sexta
… focused on a small and identifiable subset of projection neurons within the AL, which have their cell bodies grouped on the anterior surface of the AL (AC neurons). The subpopulation of about 14-20 neurons was characterized physiologically and morphologically. The anatomical features of AC …
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Modeling projection neuron and neuromodulatory effects on a rhythmic neuronal network
Projection neurons shape the activity of many neural networks. In particular, neuromodulatory substances, which are often released by projection neurons, alter the cellular and/or synaptic properties within a target network. However, neural networks in turn influence projection neuron input via …
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The Role of Nogo-A During Development of the Chick Central Nervous System
… but showed an increased distribution in large projection neurons during organization of the neuronal network. In addition, we found <em>Nogo-A</em> to be regulated by FGF application, but not by synaptic activity. We identified evolutionarily conserved regulatory sequences surrounding the Nogo …
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Higher Brain Neurons Succumb to Acute Stroke-Like Insult While Lower Brain Neurons Strongly Resist
Pyramidal neurons (PyNs) in ‘higher’ brain are highly susceptible to acute stroke injury yet ‘lower’ brain regions better survive global ischemia, presumably because of better residual blood flow. Here we show that projection neurons in ‘lower’ brain regions of hypothalamus and brainstem …
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Transitioning Between Preparatory and Precisely Sequenced Neuronal Activity in Production of a Skilled Motor Behavior
… brain remains unclear. In songbirds, premotor projection neurons in the cortical song nucleus HVC are necessary for producing learned song and exhibit precise sequential activity during singing. Using cell-type specific calcium imaging we identify populations of HVC premotor neurons associated …
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Understanding the role of striosomes in learning a decision-making task
… of mice, I find that: 1) the activity of spiny projection neurons (SPNs) in striosomes correlate with learning ability; 2) an animal's attentiveness to the task is critical for learning; 3) anatomical circuit disassembly, specifically reduced connectivity of inhibitory Parvalbumin (PV) …
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Signal transformation at the input and output of the Drosophila visual system
… I studied the filtering property of visual neurons at two levels, biophysical and circuit levels. The first study looks at signal transformation at the biophysical level, at the input of the visual system, in photoreceptors. Voltage-gated potassium channels counteract the depolarization …
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Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction
… cocaine-induced hyperexcitability of pyramidal projection neurons within the medial prefrontal cortex (mPFC). Such hyperexcitability presumably results in increased glutamatergic input to reward-affiliated brain regions such as the ventral tegemental area (VTA) and nucleus accumbens (NAc), …
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Tuning of Neuronal Excitation by a Brain Specific Microrna MIR-128: From Targets to Behavior
… their role in the control of gene expression in neurons, which underpins neuronal identity and information processing, has not been fully addressed. In this thesis, I present studies that demonstrate a potent yet previously unknown regulation of neuronal intrinsic excitability by the microRNA …
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A sexually dimorphic circuit switch in higher olfactory centres
… female receptivity. However, olfactory receptor neurons and their second-order partners, the olfactory projection neurons, do not show significantly different physiological responses to cVA. Using in vivo whole-cell electrophysiology I have identified two distinct clusters of third-order …
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A Reductionist Approach to Modeling Human Corticogenesis
… can be differentiated into various classes of projection neurons. By utilizing genome modification strategies in hPSCs, we observe that single neural progenitors possess the capacity to give rise to callosal projection neurons (CPNs) and subcortical projection neurons (SCPNs), thereby lending …
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Dividing the Preplate: Characterization of Neuronal Subpopulations in the Early Murine Cerebral Cortex
… is comprised of the earliest generated cortical neurons. Preplate neurons are a heterogenous population of future Cajal-Retzius neurons and future subplate neurons, which are derived from multiple sources of progenitors. During the formation of the cortical layers, the preplate is split into an …
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Spinothalamic tract neurons in laminae I, III and IV of the rat: a retrograde neuronal tracing study
… and thermoceptive information. Spinothalamic neurons are widely distributed within the grey matter. Lamina I represents an important nociceptive zone and provides a significant source of projection neurons, some of which project to the thalamus. A projection from cervical superficial dorsal …
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The mGluR2/3 Agonist LY397268 Improves Morphometric and Behavioral Outcomes in R6/2 Huntington's Disease Mice
… can be excitotoxic in HD and leave striatal neurons vulnerable to damage. Activation of presynaptic mGluR2/3 by an agonist dampens glutamate release from corticostriatal terminals. Treatments that target excitoxicity and oxidative stress thus may improve some of the symptoms in HD patients …
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Cracking the Odor Code: Molecular and Cellular Deconstruction of the Olfactory Circuit of Drosophila Larvae
… animal. Each of the 21 larval olfactory sensory neurons (OSNs) expresses one or rarely two ORs, along with the highly conserved olfactory co-receptor Or83b. Second, odor response profiles of 11 larval OSNs were characterized by calcium imaging. A subset of larval neurons showed overlapping …
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Cell-specific roles for CASK in the pathology of Optic Nerve Hypoplasia
… ONH, I explored whether RGCs, the projection neurons of the retina and the cells whose axons comprise the optic nerve, generate CASK. Indeed, mRNA analysis revealed expression of CASK by a large cohort of RGCs. In order to assess whether loss of CASK from a majority of RGCs leads to …
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Developmental origins of cortical circuit dysfunction in a 22q11 deletion mouse model
… the developmental origin of upper layer 2/3 projection neuron (PNs) deficits in the LgDel mouse model of 22q11DS. Bulk and single cell RNA sequencing revealed transient, cell state dependent changes in intermediate basal progenitors at the peak of upper layer neurogenesis. These changes are …
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Enhanced striatal glutamatergic function upon chronic antipsychotic action
… Cell type-specific mRNA profiling on spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways following chronic antipsychotic administration revealed cell type-specific molecular alterations indicating increases in components of the glutamatergic postsynaptic …
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EZH1 variants disrupt neurogenesis in hPSC-derived neuronal models and cause neurodevelopmental disorders
… differentiations showed that EZH1 LOF-derived neurons are less mature than wild-type neurons. Consistently, using cortical brain organoids, we uncovered that EZH1 is necessary for the coordination of cortical neurogenesis timing. Specifically, EZH1 LOF cortical organoids showed delayed …
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