Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"projection neuron"”.
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Modeling projection neuron and neuromodulatory effects on a rhythmic neuronal network
Projection neurons shape the activity of many neural networks. In particular, neuromodulatory substances, which are often released by projection neurons, alter the cellular and/or synaptic properties within a target network. However, neural networks in turn influence projection neuron input via …
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Pitx3Null Mutant (Striatal Dopamine-Deficient) Mice Have Exaggerated Spiny Projection Neuron Responses to l-DOPA and D1 Agonism and Lack Baseline Striatonigral Spiking
… as electrophysiological differences in striatal projection neuron (SPN) spike rates, SPNs <em>should </em>increase spiking during the motor response to l-DOPA. In fact, stimulating specific subsets of these neurons to spike in freely-moving wild type and parkinsonian animals causes or inhibits …
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The Roles of Wnt5 and the Drl Receptor in the Development of the Drosophila Olfactory System
… Drosophila olfactory system, olfactory receptor neurons expressing the same odorant receptors converge their axons precisely onto a specific set of projection neuron dendrites, forming glomeruli in stereotypic positions of the antennal lobe. Although many studies have revealed the crucial role of …
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Developmental origins of cortical circuit dysfunction in a 22q11 deletion mouse model
… of progenitor proliferation, neurogenesis, and neuronal maturation. Disruptions in these processes contribute to the cortical circuit pathology observed in neurodevelopmental disorders such as schizophrenia and autism, intellectual disability. The 22q11.2 deletion syndrome (22q11DS) is a major …
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The organisation of a third-order olfactory brain region in the vinegar fly
… by combining patterns of second-order olfactory projection neuron (PN) activity. While most odorants only elicit a strong behavioural response after associative learning, ecologically meaningful and evolutionarily significant odour channels trigger innate behavioural responses, likely through …
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A Reductionist Approach to Modeling Human Corticogenesis
… brain is unique in terms of its progenitor and neuronal composition, cortical areas, scale, and gene expression. Limitations in the availability of non‐human primate and human fetal material, the longer timescale of developmental processes, as well as the ethical considerations involved preclude …
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The circuit basis of olfactory mate recognition and localisation
… We discovered a previously unknown second order projection neuron class (PN) that senses cVA, and relays this signal to a neural hub for sexual behaviours - including female receptivity. We imaged the activity of sensory neurons and second order PNs in the cVA pathway while presenting the female …
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Signal transformation at the input and output of the Drosophila visual system
… I studied the filtering property of visual neurons at two levels, biophysical and circuit levels. The first study looks at signal transformation at the biophysical level, at the input of the visual system, in photoreceptors. Voltage-gated potassium channels counteract the depolarization …
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Octopaminergic Regulation of Olfactory Discrimination in the Drosophila Larval Mushroom Body Calyx
… from stereotypic olfactory input channels, the Projection Neurons (PNs). Mushroom body neurons, Kenyon cells (KCs), integrate these inputs through a combinatorial coding mechanism that allows discrimination among them. The calyx is innervated by extrinsic neurons that regulate its activity; …