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Showing 1 to 1 of 1 for “"proinsulin synthesis"”.
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Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes
… II) of TCF7L2 that regulate β cell survival, proinsulin expression and insulin maturation. The expression of many of these TCF7L2 target genes, including T2DM associated genes/loci, correlated with TCF7L2 mRNA expression in CC, but not in CT/TT genotype carriers in human pancreatic islets. …