Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"prohormones"”.
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From Prohormones to Neuropeptides: Mass Spectrometric and Bioinformatic Approaches
To test the predictive models on a larger dataset, another organism was studied. The genome of the western honey bee, Apis mellifera, is being sequenced. After deducing the neuropeptide genes through bioinformatic and mass spectrometric approaches, the neuropeptides are predicted with the …
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First survey and functional annotation of prohormone and convertase genes in the pig
… that originate as a result of cleavage of prohormones by convertases as well as other posttranslational modifications of the prohormones. Neuropeptides are important for their roles in intercellular communication as well as regulation of many processes including growth, development, immune …
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Evaluation of database search programs for accurate detection of neuropeptides in tandem mass spectrometry experiments
… other peptides resulting from the processing of prohormones. This is due to the unique characteristics of neuropeptides including release after complex processing of prohormones, potentially intense post-translational modifications and their small size. The aims of this study were: (1) to …
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Sampling Strategies for Characterization of Neuropeptides Using Mass Spectrometry and Functional Implications Into Cell -Cell Signaling
… that Hes1 influences the processing of different prohormones having possible roles during development and opens new directions for further developmental studies.
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Sampling strategies for characterization of neuropeptides using mass spectrometry and functional implications into cell-cell signaling
… including 20 unique peptides from known prohormones. This study includes mass spectrometric analysis even from individually isolated magnocellular neuroendocrine cells, where vasopressin and several other peptides are detected. At the same time, it was shown that the same approach could …
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Immunocytochemistry, Mass Spectrometry and Microengineering for the Study of Cell Signaling
… of proteolytic processing of neuropeptide prohormones and posttranslational modifications of mature peptides in individual identified neurons. Many of the aspects of neuronal signaling would better be understood, if studied in vivo. The structural and chemical complexity of the brain, …
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Novel Roles of Gastrin and Cholecystokinin in Islet Beta Cell Proliferation
… explain the effect of overexpression of these prohormones on islet replication, including a lack of effect of exogenously added gastrin and cholecystokinin peptides. These results could be attributable to an intracrine mode of signaling that will require further investigation as a possible …
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The Allatoregulatory Neuropeptides and their Genes in the fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae)
… confirms the overall tissue distribution of the prohormones as shown by RT-PCR and supports the pleiotropic functions of the peptides. Spofr-AST type-A gene is expressed in the brain, midgut, and reproductive organs of S. frugiperda larvae and adults in a time- and tissue-specific manner. Data …
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Regulation Mechanisms of Peptide Hormones in Neuroendocrine Cancers
… to detect and quantify calcitonin (CT) and its prohormones glycyllysyllysine-extended CT (CTGKK), glycyllysine-extended CT (CTGK) and glycine-extended CT (CT-G) for the first time, in DMS53 small cell lung carcinoma (SCLC) cell culture medium and lysate. Additionally, novel glycosylated versions …
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Regulation Mechanisms of Peptide Hormones in Neuroendocrine Cancers
… to detect and quantify calcitonin (CT) and its prohormones glycyllysyllysine-extended CT (CTGKK), glycyllysine-extended CT (CTGK) and glycine-extended CT (CT-G) for the first time, in DMS53 small cell lung carcinoma (SCLC) cell culture medium and lysate. Additionally, novel glycosylated versions …
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A peptidomic investigation into enteroendocrine cells and islets of humans and mice
Enteroendocrine cells (EECs) of the gastrointestinal (GI) tract and islets of Langerhans (islets) of the pancreas are endocrine cells capable of sensing nutrient intake or the nutrient content of the blood and responding by secreting peptide hormones to control various physiological functions. This …