Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"prohormone"”.
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First survey and functional annotation of prohormone and convertase genes in the pig
… that originate as a result of cleavage of prohormones by convertases as well as other posttranslational modifications of the prohormones. Neuropeptides are important for their roles in intercellular communication as well as regulation of many processes including growth, development, immune …
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Genome-wide census and expression profiling of chicken neuropeptide and prohormone convertase genes
… The complex processing of neuropeptides from prohormone proteins by prohormone convertases, combined with the evolutionary distance between the chicken and mammalian species that have experienced extensive neuropeptide research, has led to the empirical confirmation of only 18 chicken …
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The p24 family of putative cargo receptors in the early secretory pathway of a prohormone-producing cell
Contains fulltext : 19035_p24_faofp.pdf (Publisher’s version ) (Open Access)
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Chlorinated amino acids in peptide production
… small peptides human gastrin releasing peptide prohormone, cholecystokinin prohormone and oxytocin, lacking isoleucine, leucine and methionine, respectively, expressed as fusion proteins. Through simultaneous replacement of two amino acids, deuterated and fluorinated analogues of the peptides …
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Chlorinated amino acids in peptide production
… small peptides human gastrin releasing peptide prohormone, cholecystokinin prohormone and oxytocin, lacking isoleucine, leucine and methionine, respectively, expressed as fusion proteins. Through simultaneous replacement of two amino acids, deuterated and fluorinated analogues of the peptides …
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Evaluation of database search programs for accurate detection of neuropeptides in tandem mass spectrometry experiments
… other peptides resulting from the processing of prohormones. This is due to the unique characteristics of neuropeptides including release after complex processing of prohormones, potentially intense post-translational modifications and their small size. The aims of this study were: (1) to …
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Sampling strategies for characterization of neuropeptides using mass spectrometry and functional implications into cell-cell signaling
… including 20 unique peptides from known prohormones. This study includes mass spectrometric analysis even from individually isolated magnocellular neuroendocrine cells, where vasopressin and several other peptides are detected. At the same time, it was shown that the same approach could …
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Measurement of neuropeptides: From presence to release
… predicted peptide processing of the putative prohormone AC2. However, the peptides were found to be absent in the forms given by the predictive software when analyzed with MALDI MS. Later studies used Rattus norvegicus brain tissue or microdialysate to look at dynamic peptide responses. The …
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Novel Roles of PACS-1 Within the Nucleus and the Regulated Secretory Pathway
… of calcium ion channels, and retaining essential prohormone processing proteins within the regulated secretory pathway, this research truly underscores the multifunctional roles PACS-1 executes to maintain cellular homeostasis.
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Rapid social regulation of 3β-HSD activity in the songbird brain
… are non-detectable. In contrast, levels of the prohormone dehydroepiandrosterone (DHEA) are elevated year-round in the plasma and brain. The local conversion of brain DHEA to potent androgens may be critical in regulating non-breeding aggression. 3β-hydroxysteroid dehydrogenase/Δ4-Δ5 isomerase …
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Ghrelin Processing and Maturation: Developing a Molecular-Level Framework for Hormone Activation and Biological Function
… its expression and maturation, proghrelin (the prohormone of ghrelin) undergoes a unique posttranslational modification whereby a serine side chain is esterified with octanoic acid. Proghrelin then undergoes subsequent proteolysis to yield ghrelin. This octanoylation modification has been …
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Molecular and cellular insights into iron regulation
… and the role of the pro-region of the hepcidin prohormone in regulation of iron homeostasis. Iron overdose in Chinese hamster ovary-transferrin receptor variant (CHO TRVb1) cells resulted in increased hepcidin peptide secretion after 30 min and 2 hours (p<0.03) as well as 24 and 48 hours …
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The effects of vitamin D<sub>3</sub> supplementation on the aerobic and anaerobic exercise performance of recreational combat sport athletes
Vitamin D is a secosteroid prohormone classically associated with calcium metabolism and bone health. However, emerging research suggests that vitamin D may also influence exercise performance. Most research on vitamin D and exercise performance focuses on markers of muscle strength, despite …
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NESFATIN-1 AND NESFATIN-1-LIKE PEPTIDE: NUCLEOBINDIN-1/2-ENCODED INSULINOTROPIC AND ENTEROTROPIC PEPTIDES
… to NUCB1. Both proteins also retain their prohormone convertase cleavage sites. However, no information exists on whether NUCB1 encodes bioactive peptides. The fact that NUCB1 is a secreted protein suggests an endocrine function for NUCB1 and/or its encoded peptide. This research …
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Manipulating proglucagon processing in the pancreatic alpha-cell for the treatment of diabetes
… via processing of the proglucagon precursor by prohormone convertase (PC) 1/3. Proglucagon is also expressed in the pancreatic alpha-cell; however, in this tissue PC2 is typically expressed instead of PC1/3, resulting in differential cleavage of proglucagon to yield glucagon as the major …
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Neuropeptidomics: MS-base peptide identification and quantitation study
… production typically involves endoproteolytic prohormone cleavage, exoproteolytic cleavage, and post-translational modifications by a variety of enzymes. Neuropeptides are packaged into and eventually released from the large dense-core vesicles in a regulated secretory pathway. Neuropeptidomics …
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Characterisation of Guanylin and Uroguanylin in the Digestive System
… against the active human peptides and their prohormone precursors. The aim of this project was to address these deficiencies. In this thesis, specific antibodies were generated and utilised in immunoassays, which provided the ability to quantify accurately the circulating levels of proforms …
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The Effect of Allopurinol on Left Ventricular Mass in Patients with Treated Essential Hypertension
… acid reactive substances (TBARs), N-terminal prohormone B-Type Natriuretic Peptide (NTproBNP), Procollagen type I carboxy-terminal Propeptide (PICP) and soluble ST2 (sST2) and other CMRI parameters. <br/><br/>The two groups were well matched at baseline, importantly there were no statistically …
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VERTICAL SLEEVE GASTRECTOMY IMPROVES GLUCOSE HOMEOSTASIS VIA [beta]- CELL GLUCAGON-LIKE PEPTIDE-1 RECEPTOR SIGNALING BUT PROMOTES COLITIS DEVELOPMENT IN MICE
… pancreatic islets: insulin, glucagon, GLP-1, and prohormone convertase 1/3 (Chapters Two and Three). A growing number of people suffering from irritable bowel disease (IBD) also suffer from obesity and are candidates for bariatric surgery. Bariatric surgery has multiple beneficial effects, …
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The Allatoregulatory Neuropeptides and their Genes in the fall armyworm, Spodoptera frugiperda (Lepidoptera: Noctuidae)
… manner. The tissue-specific localization of the prohormone expression, as demonstrated by whole-mount in situ hybridization, confirms the overall tissue distribution of the prohormones as shown by RT-PCR and supports the pleiotropic functions of the peptides. Spofr-AST type-A gene is expressed in …
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