Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 5498 for “"progression"”.
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Colon Cancer Initiation and Progression
… an interaction map of these confirmed progression suppressors with the ~700 mutated genes that were excluded from CAN-genes, and experimentally verifying soft-agar growth enhancement in response to depletion of a subset of these genes. Collectively, this study revealed a profound …
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Modeling progression of Parkinson's disease
… tackling three clinical questions: predicting progression events, summarizing patient state, and identifying prognosis-driven subtypes. These questions are challenging because progression is highly heterogenous across patients. In this thesis, we address these challenges for Parkinson's disease …
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God Progression In The Old Testament
73 leaves
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Cell Cycle Progression Effects of Albumin
<p>Progression through G<sub>1</sub> phase of the cell cycle is controlled largely by growth factors in early G<sub>1</sub> and by nutrients in late G<sub>1</sub> indicating sufficient raw material for cell division. We previously mapped a late G<sub>1</sub> cell cycle checkpoint for lipids …
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Halting the neural progression of cancer
… and nerve-cancer interactions play in the progression of cancer and whether the SEMA3F/NRP2 axis could be targeted to inhibit this process. We hypothesized that the presence of SEMA3F would halt axonogenesis, thus slowing down the progression of tumorigenesis. Both in vivo and in vitro …
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Contusion Progression in Traumatic Brain Injury
… and interventions to prevent or limit contusion progression may improve clinical outcomes. In preclinical studies a number of pathophysiological process have been identified that contribute to brain oedema including blood brain barrier (BBB) disruption, neuroinflammation, and cerebral metabolic …
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Kant on the Progression of Representation
Recently, the key point of contention in Kant scholarship has revolved around a question concerning whether, for Kant, intuitions can play their role of presenting objects to the mind without the discursive activity of the intellect. According to 'conceptualist' interpretations, intuitions depend …
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Circadian Control of Cell Cycle Progression
… factors involved in regulating cell cycle progression under DNA damage can offer a better idea in how cells become immortal. Initially discovered through screening of a human liver cDNA library, the novel interaction between p53-Per2 was further documented using co-precipitation. …
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Suppression of Ca2+ Signaling Enhances Melanoma Progression
… to pathological phenotypes, including cancer progression. However, given the highly context-specific nature of Ca2+-dependent changes in cell function, delineation of its role in cancer has been a challenge. Hence, the role of store-operated Ca2+ entry (SOCE) in melanoma metastasis is still …
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Nherf1 – New Modifier of Colorectal Cancer Progression
… changes in NHERF1 expression correlate with CRC progression. NHERF1 loss and ectopic expression that induce massive disruption of epithelial cell polarity may, thereby, mark important steps in CRC development.
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Role of Phosphorylated Dicer1 In Tumor Progression
… oncogenic background contributes to lung tumor progression <em>in vivo</em>. Mechanisms through which phosphomimetic <em>Dicer1</em> regulates tumor progression remain undefined.</p> <p>In this thesis, I discovered that phosphorylation of DICER1 regulates lung tumor progression through a …
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Sustained Adrenergic Signaling Promotes Cervical Cancer Progression
… adrenergic signaling are known to promote tumor progression. The underlying mechanisms behind this process are not well understood. We examined the effects of sustained adrenergic signaling on cervical cancer progression through increased expression of HPV oncogenes, E6 and E7.</p> <p>Materials …
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ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
… of increased lipogenesis in the breast cancer progression. In the first part of this study, we investigated the status of fatty acid synthase (FAS) gene which is regarded as the key lipogenic gene in fatty acid biosynthetic pathway and is responsible for the synthesis of lipid molecules by …
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Extracellular Metabolic Energetics Can Promote Cancer Progression
<p>Colon cancer progression is characterized by growth of the primary tumor in the colon followed by metastasis to distant organs. The metastatic cascade involves invasion of cells from the primary tumor into the surrounding tissue, entering into and survival of cancer cells in the circulation, …
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Parental Resources, Educational Progression, and Family Formation
In this dissertation, I use longitudinal data (1997-2011) to explore two types of financial constraints during the transition to adulthood. First, I explore the relationship between parental resources (income and net household worth) and educational transitions among U.S. men and women. I revisit …
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Mitochondrial metabolism in cancer transformation and progression
Cancer cells undergo a multifaceted rewiring of cellular metabolism to support their biosynthetic needs. Although the major determinants of this metabolic transformation have been elucidated, their broad biological implications and clinical relevance are unclear. In this study, I systematically …
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