Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"programmed death-1"”.
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Programmed death-1 regulates islet-specific lymphocytes in type 1 diabetes
Programmed death-1 (PD-1) is a T cell inhibitory receptor important for tolerance maintenance. PD-1 is highly expressed on chronically stimulated T cells, such as those specific for persistent viral or tumor antigens. PD-1 pathway blockade revolutionized cancer therapy in recent years. While …
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Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung
<p>The binding of immune inhibitory receptor Programmed Death 1 (PD-1) on T cells to its ligand PD-L1 has been implicated as a major contributor to tumor induced immune suppression. Clinical trials of PD-L1 blockade have proven effective in unleashing therapeutic anti-tumor immune responses in a …
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PROGRAMMED DEATH LIGAND 1 (PD-L1) IMMUNE CHECKPOINT-MEDIATED STIMULATION OF MALIGNANT PHENOTYPES IN TUMOUR CELLS
Most studies on the Programmed Death 1 (PD-1)/Programmed Death Ligand 1 (PD-L1) immune checkpoint have focused on elucidating the signaling mechanisms leading to inactivation of immune effectors. We, along with others, have shown that signaling by the PD-1/PD-L1 immune checkpoint may be …
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Study of Regulated Cell Death In Two Systems: Pd-1 In Natural Killer Cells and Rip3 In Neurons
<p>Cell death is not only an essential phenomenon in normal development and homeostasis, but also crucial in various pathologies. It is now clear that many types of cell death can be regulated by pharmacological or genetic interventions. These were largely achieved by identifying the molecular …
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Dissecting the Role of Hedgehog Signaling in Tumor-associated Macrophages and Immunosuppression in the Tumor Microenvironment
… Specifically, we queried whether expression of programmed death ligand 1 (PD-L1) on TAMs, promoted by Hh signaling activation, play a role in suppressing CD8+ TILs. Using several murine models including a novel myeloid-specific Pdl1 knock-out mouse, we showed the tumor-derived Shh ligand …
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Altered Expression of Costimulatory Molecules in Behcet's Disease According to Clinical Activity
… T-lymphocyte antigen-4 (CTLA-4)/CD80, CD86 and programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) receptor/ligand systems are important. Also, regulatory T (Treg) cells play an important role in maintaining immune homeostasis. PURPOSE: The objective of the present study was to determine …
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T-Regulatory Cells and FLT3-Ligand in the Therapy of Cockroach Antigen-induced Asthma
… expressed significantly higher levels of programmed death-1 (PD-1), a negative regulator of immune responses. These data suggest a critical role of PD-1 in the reversal of AHR and airway inflammation by Tregs. To confirm the role of PD-1, the effect of anti-PD-1 antagonist was examined. …
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Programmed cell death-ligand 1 (PD-L1) expression in HIV-associated diffuse large B-cell lymphoma – role and regulation
… affected, such as in Sub-Saharan Africa. The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) signalling pathway is an important immunoregulatory mechanism that dampens the immune response by inhibiting T cell activity, playing a central role in controlling and maintaining tolerance …