Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 190 for “"programmed cell death"”.
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STAUROSPORINE-INDUCED APOPTOSIS/PROGRAMMED CELL DEATH
Apoptosis is the mechanism by which cells are programmed to die under a wide range of physiological and developmental stimuli. Three phases of the apoptosis process, (a) induction phase, (b) commitment phase and (c) degradation phase, have been described in interphase cells only. This study …
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Influenza A Virus Induced Programmed Cell Death
… epidemics that can result in up to 50000 deaths and 700000 hospitalizations each year, and ranks in the top ten causes of death in the United States. In addition, virulent strains of IAV have caused pandemic outbreaks triggering numerous fatalities. While tropism to the upper respiratory …
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Control of Programmed Cell Death by GCN-1
Apoptosis is a cell death phenomenon that is fundamental to the development of an organism and to the pathogenesis of disease states. Regulation of apoptosis occurs at various molecular steps, but its regulation at the translational level remains poorly understood. The phenomenon of germline …
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Genetic analysis of programmed cell death in Drosophila melanogaster
The correct regulation of programmed cell death, or apoptosis, is critical for proper development and prevention of disease. Components of the molecular mechanisms that govern apoptosis are conserved among organisms as diverse as C. elegans, Drosophila, and mammals. A central step in the execution …
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Molecular studies of Fas signaling and programmed cell death
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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A New Type of Programmed Cell Death in C. Elegans
<p>The most intensively studied form of programmed cell death (PCD) is apoptosis, which is characterized by stereotypical morphological features including chromatin compaction and by a requirement for the activity of caspase proteases, which are controlled by conserved gene pathways. Although …
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Studies of programmed cell death in the nematode caenorhabditis elegans
Programmed cell death is an evolutionarily conserved process that plays critical roles in normal animal development and has been extensively studied in C. elegans. During programmed cell death, caspases are activated in the dying cell. The cell corpse is engulfed by a neighboring cell and degraded. …
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Genetic and molecular studies of programmed cell death in the nematod Caenorhabditis elegans
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Genetic and Molecular Characterization of Programmed Cell Death in the C.elegans Tail-Spike Cell
… in deciphering the molecular basis of programmed cell death. However, despite extensive characterization of broadacting cell death genes, the molecular events triggering cell-specific activation of the cell death machinery remain, for the most part, unknown. In some C. elegans somatic …
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Gingival MSCs Improve Bone Phenotype in Ovariectomy-Induced Osteoporosis via Programmed Cell Death Pathway
… health institutions. Gingival Mesenchymal Stem cells (GMSCs) are a distinctive population of dental tissue-derived stem cells that possess uniquely high proliferation abilities and are capable of self-maintenance and multipotent differentiation. Their use has been investigated in different …
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Molecular genetic analysis of larval visual system development and programmed cell death in Drosophila
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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Genetic and molecular studies of cell-autonomous execution during programmed cell death in C. elegans
Apoptosis or programmed cell death was originally defined by evolutionarily conserved morphological characteristics that include shrinkage of cell volume and chromatin condensation. Apoptosis functions as a highly controlled mechanism for the elimination of unwanted or damaged cells and is …
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Analysis of genes involved in cell-specific control of programmed cell death in Caenorhabditis elegans
Programmed cell death is an important process regulating cell number in the development of all animals. Two genes, ces-1 and ces-2 control programmed cell death in a subset of developing neurons in C. elegans. To understand how ces-1 and ces-2 might act to regulate programmed cell death, we have …
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Characterization of three Drosophila melanogaster regulators of programmed cell death that lead to caspase activation
Programmed cell death plays an important part in metazoan development as well as in disease. The morphology of cells undergoing programmed cell death has been carefully defined and found to be conserved between a variety of species. A number of key regulators of this process were first identified …
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Phagocytosis promotes programmed cell death and is controlled by Rac signaling pathway in C. elegans
Programmed cell death is important in development, homeostasis, and disease. In the nematode Caenorhabditis elegans, four genes, egl-1, ced-9, ced-4, and ced-3, control the execution of cell death and define a molecular pathway for cell death conserved in humans. Seven genes control the engulfment …
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The pro-apoptotic Siva-1 protein plays a significant role in DNA damage-induced programmed cell death.
… plays a significant role in DNA damage-induced programmed cell death.
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Light Sheet Microscopy and Image Analysis of Neural Development and Programmed Cell Death in C. Elegans Embryos
<p>The positioning of neuronal cell bodies and neurites is critical for intact functioning of the nervous system. Mapping the positions of the soma and neurites in the brains of developing embryos as important central nervous system structures are being created may yield novel insight into the role …
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Estrogen Receptor -Dependent and Estrogen Receptor-Independent Pathways for Tamoxifen and 4-Hydroxytamoxifen-Induced Programmed Cell Death
… metabolite, 4-hydroxytamoxifen (OHT), induce programmed cell death through distinct ER-dependent and ER-independent pathways. The ER-independent pathway requires 10--20 muM TAM or OHT and occurs in ER-negative cells. Nanomolar concentrations of OHT activate an ER-dependent pathway. …
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Genetic Analysis of Hox Transcription Factors and Cofactors in the Regulation of Programmed Cell Death in C Elegans
… kingdom, apoptosis is exquisitely regulated in cell-specific and context-specific ways to ensure proper development and tissue homeostasis. In many cases, transcriptional pathways carry out this regulation by mechanisms that are not completely understood. Studies of programmed cell death in the …
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Nanosecond Pulsed Electric Field Induction of Programmed Cell Death Is Cell Type Dependent: An <i>in vitro</i> Study
… of apoptosis evasion and enforcing cancer programmed cell death. To develop nsPEFs as an anticancer method, a comprehensive understanding of cell death mechanisms is required. The overall objective of this dissertation is to elucidate molecular mechanisms underlying effects of nsPEFs on E4 …
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