Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"prognostic signature"”.
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Oncogenic Pathways and Molecular Prognostics in Neuroblastoma
… genes with the snoRNPs resulted in a 4-gene prognostic signature. Calculating the ratio (R-score) between the expression of the good and bad prognostic genes removed the need for housekeeper normalization, and provided a means of individual patient analysis. Application of a fixed-value …
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Investigating CD8+ T-cell gene expression signatures as disease prognostic biomarkers in paediatric inflammatory bowel disease.
… in adult IBD cohorts identified promising signatures, including a T-cell exhaustion signature, to predict disease outcome in these patients. Hypothesis and aim: We hypothesised that adult CD8+ T-cell prognostic signature and T-cell exhaustion signature would also predict outcome in …
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Defining the clinical importance of epithelial-stroma-immune signalling in colorectal cancer using a molecular pathology approach
… subtyping of CC has identified a poor-prognostic group of patients characterised by high levels of epithelial-to-mesenchymal transition (EMT) signalling and an abundance of stroma (particularly fibroblasts) in their tumour microenvironment. To date, there has been inconsistent data …
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Integration of Genome Scale Data for Identifying New Biomarkers in Colon Cancer: Integrated Analysis of Transcriptomics and Epigenomics Data from High Throughput Technologies in Order to Identifying New Biomarkers Genes for Personalised Targeted Therapies for Patients Suffering from Colon Cancer
… diagnostic targets and prediction of reliable prognostic signatures for clinical practice using microarray expression datasets. We performed an integrated analysis of gene expression data based on genetic, epigenetic and extensive clinical information using unsupervised learning, correlation …
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Genetic Profiling in Soft Tissue Sarcoma
… diagnostic reproducibility and insufficient prognostic markers make clinical management of these tumors difficult. This thesis has applied microarray-based gene expression and copy-number profiling to STS. The studies provide clues to the genetic pathways involved in STS development and …
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Not-so-innocent bystanders? Investigating non-antigen specific CD8+ T cell activation in autoimmune prognosis
… Laboratory identified a novel gene expression signature in T cells predictive of clinical outcome in anti-neutrophil cytoplasmic antibodies-associated vasculitis, systemic lupus erythematosus, Crohn’s disease, and ulcerative colitis that is not associated with diagnosis. Two modules …
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Prostate cancer evolution employing artificial intelligence to enhance biomarker discovery
… time, the most informative and succinct gene signatures from transcriptomic datasets.<br/><br/>Differentially expressed genes (DEGs) from the isolated prostate side-populations (SPs) have shown these prostate SPs to be genetically distinct from terminally differentiated cells. DEGs were also …