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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 68 for “"prognostic marker"”.

  1. Telomerase a prognostic marker an therapeutic target

    Thakkar, Dipti SUniversity of Central Lancashire2010

    … can be potentially used as a glioma progressive marker. This is the first study to report the potential involvement of telomerase in the regulation of vimentin expression. This study also identified that combination therapy, comprising siRNA targeted towards telomerase regulatory mechanisms and …

    cent-lancashire Repository record

  2. Cell-free DNA and tumor exosome cargo as diagnostic and prognostic marker for prostate cancer

    Temilola, DadaDepartment of Integrative Biomedical Sciences (IBMS)2023

    … antigen (PSA) has long been introduced as a biomarker for screening in PCa diagnosis. However, serum PSA has low sensitivity for PCa diagnosis which has led to serious harm such as overdiagnosis and other complications of treatment for indolent disease. This makes it imperative to search for …

    cape-town Repository record

  3. Occluson Pattern in Circle of Willis: Prognostic Marker for Endovascular Treatment in Acute Carotid Terminus Occlusion

    이, 선욱2014

    … high. In this study, we aimed to discover a prognostic marker for acute CTO, thereby selectively sorting out patients who are not worthwhile for further endovascular treatment. METHODS: This is a retrospective study by reviewing our prospectively registered database of acute ischemic stroke …

    ajou Repository record

  4. CLINICAL APPLICATIONS OF PARAOXONASE-1 IN DOMESTIC ANIMALS: BEYOND CONVENTIONAL INFLAMMATORY MARKERS

    SCAVONE, DONATELLAUniversità degli Studi di Milano2022

    … and oxidative conditions are based on markers that are so far considered accurate but may lack specificity and prognostic utility. In the last years’ research, interest has grown about the role of Paraoxonase-1 (PON-1) in the pathogenesis and diagnosis of many diseases characterized by …

    milano Repository record

  5. Early Prostate Cancer, On prognostic markers and predictors of treatment outcome after radical prostatectomy.

    Khatami, Ali2007

    … the past ten years. Today’s clinically used prognostic markers are not accurate enough to separate the potentially life-threatening tumours from the insignificant ones in 50-80% of newly diagnosed PCs. Curative treatment of all men with early PC results in substantial overtreatment and …

    goteborg Repository record

  6. Roles of the ING1 Epigenetic Regulator in Breast Cancer

    Thakur, SatbirGraduate Studies2014

    … role of ING1 as a therapeutic agent and prognostic marker for breast cancer. We began by asking whether dysregulating epigenetic pathways with different chemical inhibitors could show synergistic effects with ING1 on killing cancer cells. We tested whether ING1 could synergize better with …

    calgary Repository record

  7. Trasduzione del segnale inositide-dipendente nel carcinoma della mammella

    Molinari, Chiara <1978>Alma Mater Studiorum - Università di Bologna2008

    … find out whether this enzyme could be a suitable prognostic marker for this neoplasm. Our results show that 83% of cases had aneusomies at the 20p12 level, and the most frequent alteration is a gain in this specific locus. Indeed, we found that this amplification is not related to the invasion …

    bologna Repository record

  8. A multifaceted study of the receptor tyrosine kinase Axl with focus on Renal Cell Carcinoma

    Gustafsson, AnnaDivision of Clinical Chemistry and Pharmacology, Faculty of Medicine, Lund University2009

    … and with great need for proper molecular prognostic markers. With the opportunity of having a large RCC patient material, we could conclude Axl and Gas6 to correlate with patient survival outcome (Paper I). Furthermore, we found Axl expression in the primary tumor, at time of nephrectomy, …

    lund Repository record

  9. Oral and Oropharyngeal Cancer - Aspects on Epidemiology and Prognostic Markers

    Annertz, KarinLund University, Faculty of Medicine, Otorhinolaryngology (Lund)2014

    … a previous study been found to be an independent prognostic marker for poor outcome in head and neck SCC. This thesis aimed to investigate the epidemiological changes for tongue cancer in the Nordic countries and to compare some possible predictive factors for OOPHSCC. During the period 1960-1994, …

    lund Repository record

  10. Functional In Vivo Screen Identifies Pygo2 As A Putative Gene to Promote Prostate Cancer

    Pan, Xiaolu2019

    … the results suggest PYGO2 as a potential prognostic marker as well as a therapeutic target. Additional functional characterization of PYGO2 in prostate cancer pathogenesis is warranted and ongoing.</p>

    uthsc Repository record

  11. The G protein-coupled receptor GPR30 signalosome - A novel G protein-independent mechanism regulating cAMP signaling and receptor trafficking

    Broselid, StefanDrug Target Discovery2014

    … expression in ER+ breast cancer is a favorable prognostic marker for distant-disease-free survival. (4) GPR30 confer some constitutive pro-apoptotic signaling but also readily sensitizes the cells to other apoptotic stimuli. (5) GPR30 directly associates with RAMP3 in-vivo and in-vitro and RAMP3 …

    lund Repository record

  12. Prediction of the Outcome in Cardiac Arrest Patients Undergoing Hypothermia Using EEG Wavelet Entropy

    Moshirvaziri, Hana2023

    … The present work aimed at the development of a prognostic marker for the CA patients undergoing hypothermia. A quantitative measure of the complexity of Electroencephalogram (EEG) signals, called wavelet sub-band entropy, was employed to predict the patients’ outcomes. We hypothesized that the …

    claremont Repository record

  13. Immunhistochemische Analyse des p16-Proteins bei Patientinnen mit primärem Mammakarzinom und seine prognostische Relevanz

    Scozzai, CorinnePublikationsserver der RWTH Aachen University2006

    … and the results were compared with established prognostic parameters. In the univariate survival analysis we first demonstrated the significant association of the patients survival time with histologic staging (pTMN =0,0005, pN = 0,0005, pT = 0,0141, pM = 0,0081) and with histologic grade (p = …

    aachen Repository record

  14. Verlauf der PCT-Blutkonzentrationen während und nach Herzoperationen mit extrakorporaler Zirkulation bei Kindern

    Babilas, KirstenPublikationsserver der RWTH Aachen University2007

    … to these results, PCT can not serve as a prognostic marker for children undergoing heart surgery. In further clinical and experimental studies the place of PCT synthesis as well as the cells which synthesise PCT after EKK must be elucidated.

    aachen Repository record

  15. CD200: A Novel Therapeutic Target for Chronic Lymphocytic Leukemia

    Wong, Karrie2013

    … disease, inferring that sCD200 may be a novel prognostic marker for CLL. The in vivo function of sCD200 was investigated for its ability to support engraftment of CLL splenocytes in NOD.SCID mice. Infusion of sCD200hi CLL plasma, but not sCD200lo normal plasma, enhanced engraftment of …

    toronto-retro Repository record

  16. AKR1B10 PROMOTES BREAST CANCER METASTASIS THROUGH INTEGRIN α5/δ-CATENIN-RAC1 SIGNALING PATHWAY

    Huang, Chenfei

    … and metastatic breast cancers, being a negative prognostic marker. This study characterized the molecular mechanisms of action of AKR1B10. Ectopic expression in breast cancer cells MCF-7 and MDA-MB-231 or siRNA-mediated silencing in BT-20 cell of AKR1B10 affected cell adhesion, migration and …

    siu-theses Repository record

  17. Understanding Acquired Resistance to Lapatinib In Breast Cancer Cells

    Tseng, Jen-Te2010

    … Expression levels of ErbB2 are used as a prognostic marker for Lapatinib response; however, even among breast tumor cell lines that express similar levels of ErbB2 there is marked difference in their proliferative responses to Lapatinib. To understand the mechanisms of acquired resistance, …

    uthsc Repository record

  18. Cyclin B1 Mediates The Effect of Uchl1 In Promoting Cell Cycle Progression In Uterine Papillary Serous Carcinoma

    Kwan, Suet Ying, <p>0000-0002-8222-3827</p>2018

    … In summary, we have identified UCHL1 as a prognostic marker for UPSC and a viable therapeutic target.</p>

    uthsc Repository record

  19. Novel Paclitaxel Nanoparticles for Enhanced Therapeutic Effects in Breast Cancer

    Chowdhury, Pallabita2021

    … factor receptor (HER2), there is no specific prognostic marker for targeting this aggressive cancer. In spite of rapid advancement in breast cancer with agents such as Trastuzumab in HER2 positive, chemotherapy with cytotoxic agents remains the mainstay treatment for TNBC. Although these …

    tenn-hsc Repository record

  20. Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer

    Lundgren, KatjaKatja Lundgren2010

    … strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast cancer is essential to effectively improve therapies and diagnosis. The main goal of this thesis was to identify putative markers for prediction of clinical …

    lund Repository record

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