Global ETD Search
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Showing 1 to 11 of 11 for “"proglucagon"”.
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In Vitro Characterization of Proglucagon Cleavage by PCI
… substrate.|Milligram quantities of methionylated proglucagon (Met-PG), its N-terminal derivative glicentin (Met-Gli) and the C-terminal derivative major pro glucagon factor (Met-MPGF) were successfully expressed and purified for use as model substrates to characterize the cleavage specificity of …
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Butyrate-Induced Expression of Proglucagon: Implications for Enteroendocrine Signaling and Intestinal Growth
… the distal ileum and colon which expresses the proglucagon gene. Proglucagon encodes a number of important hormones, namely glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2), glicentin, and oxyntomodulin and thus may impact intestinal development and dysfunction, type 2 diabetes, …
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Butyrate-induced expression of proglucagon: implications for enteroendocrine signaling and intestinal growth
… the distal ileum and colon which expresses the proglucagon gene. Proglucagon encodes a number of important hormones, namely glucagon-like peptide 1 (GLP-1), glucagon-like peptide 2 (GLP-2), glicentin, and oxyntomodulin and thus may impact intestinal development and dysfunction, type 2 diabetes, …
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Manipulating proglucagon processing in the pancreatic alpha-cell for the treatment of diabetes
… in the intestinal L-cell via processing of the proglucagon precursor by prohormone convertase (PC) 1/3. Proglucagon is also expressed in the pancreatic alpha-cell; however, in this tissue PC2 is typically expressed instead of PC1/3, resulting in differential cleavage of proglucagon to yield …
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Butyrate-induced upregulation of intestinal glucose transport and signaling pathways represent a possible nutrient therapy for individuals with malabsorptive disorders
… Sprague Dawley rat as an in vivo model. Finally, proglucagon mRNA, and the G-protein coupled receptors (GPCR), Free Fatty Acid Receptor FFAR2) and Free Fatty Acid Receptor 3 (FFAR3), were measured. To establish that butyrate increased the glucose transport capacity of the intestine through …
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Effects of exogenous and endogenous factors on appetite regulation in broiler chicks and Japanese quail
… in c-Fos mRNA after FA treatment. OXM, a proglucagon-derived peptide produced in the gastrointestinal tract, administered intracerebroventricularly (ICV) or IP in Japanese quail (Coturnix japonica), resulted in a decrease in food intake for 3 hours post-injection. There was an increase in …
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Regulation of Energy Balance by Dietary Protein
… the tissue distribution of the transcripts for proglucagon, glucose-dependent insulinotropic peptide, peptide YY and their cognate receptors in feline peripheral tissues and the effects of the consumption of high-protein diets on the concentrations of circulating metabolites and metabolic …
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Short-Chain Fatty Acids and Glucagon -Like Peptide-2 Enhance Intestinal Development and Adaptation
… increase in ileal and colonic mRNA abundance of proglucagon, the gene that encodes GLP-2. Thus, GLP-2 may mediate the intestinotrophic effects of butyrate. Further evidence for the intestinotrophic effects of GLP-2 was investigated using a degradation-resistant GLP-2 analog, teduglutide, in adult …
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VERTICAL SLEEVE GASTRECTOMY IMPROVES GLUCOSE HOMEOSTASIS VIA [beta]- CELL GLUCAGON-LIKE PEPTIDE-1 RECEPTOR SIGNALING BUT PROMOTES COLITIS DEVELOPMENT IN MICE
… GLP-1R signaling is a novel regulator of α-cell proglucagon processing after VSG; and demonstrates VSG surgery aggravates colitis in mice. The knowledge gained from this research is novel and serves as an anchor for further elucidating the mechanisms by which VSG surgery improves conditions such …
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Assessment of blue whiting protein hydrolysate bioactivities using cell culture models
… w/v dw) increased active GLP-1 secretion and proglucagon production in STC-1 cells compared to the basal control (Krebs-Ringer buffer) (p<0.05), possibly via intracellular calcium signalling, however this activity was lost following SGID. In addition, neither pre- nor post-SGID hydrolysates …
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Isolation and Characterization of Regulatory Peptides from Two Tetraploid Species, the Pallid Sturgeon, Scaphirhynchus albus, and the African Clawed Frog, Xenopus laevis
… pathway of posttranslational processing of proglucagon. Somatostatin-14 isolated from the pallid sturgeon is identical to human somatostatin-14, and was also isolated in a second molecular form with an oxidized Trp8 residue. [Pro2]somatostatin-14, previously isolated from the pituitary of …