Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"progestin"”.
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Progestin regulation of follicular dynamics in beef cattle
Progestins, such as melengestrol acetate (MGA) and Controlled Internal Drug Release (CIDR), can inhibit ovulation and synchronize estrus in cattle. However, long-term MGA treatment, in the absence of a corpus luteum, results in the formation of a persistent follicle (PF). Fertilization of a oocyte …
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NUCLEAR PROGESTIN RECEPTOR REGULATES FERTILITY AND SPAWNING IN FEMALE CICHLID ASTATOTILAPIA BURTONI
… varies across the reproductive cycle. I look to progestin as a potential regulator of PGF2α sensitivity. Increasing progestin levels (important in final egg maturation) precede PGF2α levels which rise during spawning. Additionally, progestin upregulates ptgfr mRNA in the preoptic area (POA) of …
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Priming with Oral Progestin Before Ovulation Induction Facilitates Ovarian Function in the Cat (Felis catus)
… short-term ovarian suppression with oral progestin (altrenogest; ALT) before ovulation induction was investigated. The hypothesis was that oral progestin priming would prevent spontaneous ovulation, improve ovarian responsiveness to exogenous gonadotropins and mitigate adverse effects …
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Inhibition of progestin-induced VEGF in mammary cancer by curcumin and 2-methoxy estradiol and their potential role as anti-angiogenic & chemopreventive compounds
Estrogen/Progestin combined hormone replacement therapy (HRT) is commonly prescribed to alleviate the symptoms of menopause in women. Combination HRT however is associated with an increased risk of breast cancer, an effect that has been attributed to the progestin component, the most common of …
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Cross talk between the glucocorticoid receptor and the progesterone receptor in modulation of progestin responses and HIV-1 infection
… that the use of the injectable contraceptive progestin Depotmedroxyprogesterone acetate (DMPA) is associated with increased HIV-1 acquisition is controversial. However, animal and ex vivo data reveal plausible biological mechanisms whereby MPA may increase HIV-1 acquisition. Relatively high …
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Effect of progestin-based hormonal contraceptives on genital inflammation and Th17 cell activation in adolescents at high risk for HIV infection
… some hormonal contraceptives (HC), such as progestin only-injectable contraceptives DMPA and NET-EN, have been associated with significantly increased risk for HIV infection. These HC together with sexual immaturity may increase activation of CD4+ T cells in the female reproductive tract …
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The effects of varying the interval from follicular wave emergence to progestin withdrawal on follicular dynamics and the synchrony of estrus in beef cattle
… the interval from follicular wave emergence to progestin removal on follicular dynamics and the synchrony of estrus. The experimental design was a 2x2x2 factorial with GnRH or estradiol-17 beta (E2) + progesterone (P4), controlled internal drug-releasing device (CIDR) treatment duration, and PG …
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Effects of energy and protein levels on attainment of puberty and steroid hormone production in captive female white-tailed deer
… diets caused a significant (p<0.05) increase in progestin concentrations over low energy diets. Progestin concentrations were significantly (p<0.05) higher during January (especially the first ⅓ of January) than any other month examined. Nine of 11 high energy animals and 0 of 8 low energy …
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I. Molecular Probes for the Progesterone Receptor. II. Design and Synthesis of a Rigidly Constrained Peptidomimetic as a Potential Beta-Turn Mimic. III. Isolation and Characterization of Novel Ion Channel Modulators From Commercial Phenol Red Preparations
… -R 5020 (K$\sb{\rm d}$ = 0.379 nM). ($\sp3$H) -progestin aryl azide 12 exhibits high photoattachment efficiency (60% at 1 h) compared to the commonly used PR PAL reagent ($\sp3$H) -R 5020 (2.2% at 1 h), and is the most efficient progesterone receptor PAL reagent prepared to date. …
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Hormonal modulation of sex steroid hormone receptors and oncogenes in human breast cancer cells
… cancer metastasis, the effects of estrogen, progestin and hormone antagonists on the levels of estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu mRNA and protein have been studied in human breast cancer cell lines using cDNA and antibody probes. In all studies, protein response …
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Estrogen Receptor and Progesterone Receptor Synthesis and Degradation in Target Cells
… and to examine the effect of estrogen and progestin on PR levels.
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Therapeutic and chemopreventive potential of luteolin against growth and metastasis of breast cancer
… of menopause. Recent studies implicate the progestin component of HRT as being most likely responsible for elevated breast cancer risk and increased mortality. Using animal models and cell culture we explored the preventive and therapeutic potential of luteolin (LU), a naturally-occurring …
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Influence of physical restraint and restraint-facilitating drugs on blood measurements of white-tailed deer and other selected mammals
… P and RO-5-3448 administration and in shot deer. Progestin levels increased following SCC-treatment and manual restraint. Progestins decreased or did not change following RO-5-3448 and PH + P administration and after shooting. Estrone levels increased following SCC-treatment in wild deer. …
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Cell-Type-Specific Requirement of Progestereone Receptor for Suppression of Cell Proliferation and Carcinogenesis in the Cervix
… Our lab has demonstrated that synthetic progestin medroxyprogesterone acetate (MPA) prevents and regresses cervical cancer in the HPV transgenic mouse model. Our lab also has demonstrated that stromal estrogen receptor alpha (ERα) mainly mediates pro–tumorigenic action of E2. The goal of …
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Effect of P.G. 600 on the timing of ovulation in gilts treated with Regu-mate
… America Inc., Millsboro, DE) in gilts fed a progestin (Regu-mate; Intervet America Inc.) compared with gilts receiving progestin alone. We hypothesized that P.G. 600 altered the timing of ovulation, therefore mating gilts 12 and 24 h after first detection of estrus, as is common in the swine …
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The molecular actions of medroxyprogesterone acetate on androgen receptor signalling and the promotion of breast cancer.
… equine estrogens (CEE) and the synthetic progestin medroxyprogesterone acetate (MPA) and increased breast cancer risk in post-menopausal women. Since the first WHI report in 2002, other observational studies have demonstrated that it is the addition of the synthetic progestin in the cHRT …
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Appearance Over Function - The Impact of Long-Term Oral Contraceptive Use on Brain Development, Breast Tissue Composition, and Future Lactation Outcomes
… The introduction of synthetic estrogen and progestin through COC use during this time may disrupt natural hormonal pathways, potentially altering neuroendocrine signaling and breast tissue maturation. Such changes may have lasting consequences, including impaired milk production, a weakened …
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Rhenium and technetium-labeled progestins, the development of receptor-directed agents for diagnostic imaging or therapy
… conjugate systems have been prepared in which a progestin is linked to a metal chelate system. These are bis-amino bis-thiol (BAT or N$\sb2$S$\sb2$) systems and are linked through carbon-21 of progesterone or the 17$\alpha$- or 11$\beta$-position of a nortestosterone type progestin. As a model …
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Effects of long-term hormone treatment on cognitive behavior and the structure of the medial prefrontal cortex during aging in female rats
… acetate (MPA), the most commonly prescribed progestin. The aging brain may respond differently to the presence of these hormones. Therefore, the effects of long-term hormone treatment during aging on cognition and neuroanatomy were investigated. Female Long Evans hooded rats were …
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ESTROGEN, VASCULAR INFLAMMATION, AND INTERLEUKIN-17 IN RELATION TO ATHEROSCLEROSIS IN A FEMALE NONHUMAN PRIMATE MODEL
… Initiative (WHI) study, and Heart and Estrogen/progestin Replacement Therapy have demonstrated a lack of beneficial effects provided by ET. The timing hypothesis of hormone therapy (HT) emerged from the disparity between observational studies and RCTs. The hypothesis states that exogenous …
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