Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 511 for “"progenitor cells"”.
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Transposable Elements in Neural Progenitor Cells
… called Line-1 was found to be active in neural progenitor cells and in the brain. Several studies report Line-1 transcription and frequent retrotransposition during normal brain development, with further evidence that Line-1 induced retrotransposition can influence neuronal gene expression. …
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Haematopoietic progenitor cells in carotid disease
Introduction Haematopoietic progenitor cells (HPCs) may attenuate the response to acute vascular injury by maintaining endothelial integrity and function. The aim of this study was to determine whether circulating HPC number and function, and mobilising cytokines, reflect significant carotid …
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Liver regeneration by hepatic progenitor cells
… with stem cell like qualities known as hepatic progenitor cells (HPCs). HPCs are particularly active during massive or chronic liver injury and therefore are an attractive target for much needed novel therapies to enhance regeneration in patients for whom the only current effective therapy is …
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Epigenetic Regulation of Muscle Stem and Progenitor Cells
… The mechanisms regulating muscle stem and progenitor cell identity have ramifications for understanding all aspects of myogenesis. The epigenetic mechanisms regulating muscle stem cells are therefore important aspects for understanding the regulation of muscle regeneration and maintenance. …
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Studies on renal progenitor cells and kidney cancer
… type intermingled between the proximal tubular cells of the nephron in normal human kidney. These cells share marker expression with regenerating tubules and display stem cell-like abilities as well as distinct morphological properties, such as low mitochondrial content and extensive structural …
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Redefining endothelial progenitor cells using a proteomics approach
The concept of endothelial progenitor cells (EPCs) has attracted considerable interest in cardiovascular research, but despite a decade of research there are still no specific markers for EPCs and results from clinical trials remain controversial. To identify membrane proteins, which could serve as …
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Neural Stem / Progenitor Cells in the Adult Mouse Hypothalamus
Adult neural stem cells are now widely accepted to exist in the neurogenic regions of the subventricular zone and dentate gyrus; however there is increasing evidence to suggest that neurogenesis may also occur in other brain regions. It has been proposed that one such population of neural stem …
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Role of Fra-2/AP-1 in Myogenic Progenitor Cells
… expression profiles during myogenesis in C2C12 cells, the expression profile of AP-1 is different among proliferative myoblasts, differentiating myoblasts, differentiated myotubes and reserve cells, indicating context-dependent spatial and temporal roles. We found that the expression profile of …
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Suppression of telomerase component dyskerin in human haematopoietic progenitor cells
… Replicative deficiency of human haematopoietic progenitor cells (HPCs) has been attributed to inadequate telomere length reserve. However, the unexplained phenotypic heterogeneity of these disorders suggest there may be additional mechanisms involved. Dyskerin is a nucleolar protein that …
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Controlled Migration of Retinal Progenitor Cells Within Electro-Chemotactic Fields
… to damage and death of retinal photoreceptor cells. Studies in mouse retina have suggested that transplantation of isolated post-natal or stem cell-derived retinal progenitor cells (RPCs) to replace apoptotic or damaged photoreceptors may be a novel approach to restore vision. Thus far, …
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Identifying the Origin of Zebrafish (Danio rerio) Renal Progenitor Cells
… the human kidney by the presence of adult renal progenitor cells (RPCs) that are capable of neonephrogenesis. These cells can be labeled with eGFP in the Tg(lhx1a:egfp) transgenic line. Using this transgenic line, zebrafish kidney regeneration was shown to utilize tubule repair mechanisms early …
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Mapping the transcriptional landscape of haematopoietic stem and progenitor cells
… cell-fate decisions of haematopoietic stem and progenitor cells (HSPCs). Individual haematopoietic stem cells (HSCs) decide between self-renewal and differentiation and can generate all mature cell types. Cell-fate decisions are made at the single-cell level and are governed by regulatory …
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Spatial organisation of proto-oncogenes in human haematopoietic progenitor cells
The eukaryotic cell nucleus is a highly organised organelle, with distinct specialised sub- compartments responsible for specific nuclear functions. Within the context of this functional framework, the genome is organised, allowing contact between specific genomic regions and sub-compartments. …
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Balancing Renewal and Differentiation of Progenitor Cells in the Developing Kidney
… likely due to the absence of nephron precursor cells. If nephron number falls below a certain threshold, the kidneys stop functioning properly pre-disposing individuals to a myriad of medical conditions including renal failure. While dialysis is a treatment option, the survival rate of a …
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Biology of stem cells and myeloid progenitor cells in myelodysplastic syndromes.
Contains fulltext : 52863.pdf (Publisher’s version ) (Open Access)
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Stereological Analysis of Oligodendrocyte Progenitor Cells In the Adult Mouse Brain
… histological analysis of these closely apposed cells, corresponds to experiment 4.
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