Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 178 for “"progenitor cell"”.
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Olfactory progenitor cell transplantation into the mammalian inner ear
A practical consideration in the development of cellular therapy technology for the inner ear is the development of an in vitro model for assessing the optimal conditions for successful application of cells. The first part of this thesis describes the adaptation of the cochleovestibular structure …
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The transcriptional regulation of skeletal muscle progenitor cell fate
… events that lead to the expression of muscle progenitor markers. This series of studies aims to further understand the mechanisms which regulate commitment to the myogenic lineage. In Chapter 2, Sox 15 was found to be sufficient for the expression of pre-skeletal mesodermal markers, but failed …
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Novel intracellular signalling regulators of cartilage progenitor cell populations
… delivery of bone marrow and its constituent cell populations to the site of cartilage damage to form a regenerative clot have proved promising in repairing joint cartilage defects. In order to improve such regenerative technique, further research is required to provide a deeper understanding …
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Molecular Mechanisms of Airway Epithelial Progenitor Cell Maintenance and Repair.
… are lined with a continuous layer of epithelial cells. Epithelial cells in the distal most part of the lung, the alveolar space, are specialized to facilitate gas exchange. Proximal to the alveoli is the airway epithelium, which provides an essential barrier and is the first line of defense …
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Changes in the Oligodendrocyte Progenitor Cell Nuclear Lamina During Ageing
… can be generated from the oligodendrocyte progenitor cell (OPC), a multipotent progenitor cell of the central nervous system. However, the efficiency of this regenerative process declines with ageing, leading to neurodegeneration and progressive neurological dysfunction in older individuals …
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Hdac3 is a Critical Regulator of Neural Crest Progenitor Cell Biology
… on the coordinated development of multiple progenitor cell pools. Specific transcriptional programs regulate the specification, expansion, migration and eventual differentiation of these progenitor cell populations, and tight control of these programs is essential for normal development to …
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Elucidating the Relationship Between Macrophages and Synovial Mesenchymal Progenitor Cell Chondrogenesis
… macrophages interact with synovial mesenchymal progenitor cells (sMPCs) in the joint. sMPCs are able to differentiate into cartilage but for unknown reasons, sMPC chondrogenic capacity is lost in OA. This thesis elucidates the relationship between macrophages and sMPC using synovial explants …
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Identification of Novel Prostate Cancer Subtypes Using Stem/Progenitor Cell Models
Prostate cancer (CaP) is the most commonly diagnosed cancer, and the second leading cause of cancer-related deaths in American men. Despite earlier detection, CaP continues to be fatal in ~10% of cases and better treatments for patients with advanced disease are desperately needed. Understanding …
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Microgravity Exerts an Age-Dependent Effect on Cardiovascular Progenitor Cell Development
<p>The heart and its cellular components are profoundly altered by missions to space and injury on Earth. Increasing evidence has identified that one such alteration induced by spaceflight is the promotion of the efficacious use of stem cells in therapies on Earth. For this reason, neonatal and …
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The brain microenvironment and its role in oligodendrocyte progenitor cell ageing
… in molecular interplay between the brain extracellular matrix (ECM), oligodendrocyte progenitor cells (OPCs) and astrocytes. During ageing the resident brain progenitors undergo cellular arrest causing a diminished regenerative response. Increasing research evidence supports the notion that the …
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New approaches to improve the cord blood unit hematopoietic progenitor cell content
… to bone marrow and peripheral blood stem cell transplantation. To this day, over 400 000 unrelated donor cord blood units have been stored in cord blood banks worldwide. To enable successful cord blood transplantation, recent efforts have been focused on finding ways to increase the …
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DIABETES IMPAIRS THERAPEUTIC EFFECT OF ENDOTHELIAL PROGENITOR CELL EXOSOME-MEDIATED MYOCARDIAL REPAIR
… have shown that bone marrow-derived endothelial progenitor cells (BM-EPCs) promote cardiac neovascularization and attenuate ischemic injury in animal models. Lately, emerging evidence supports that exosomes (Exo), a family of extracellular vesicles, mediate stem cell therapy by carrying …
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Investigation of a pancreatic derived progenitor cell population for use in regenerative medicine
… insulin replacement therapy. Pancreatic stem cells or progenitor cells have been proposed as an attractive therapy either as a source of cells for in vitro expansion and differentiation to islets for transplantation, or as a direct in vivo cell therapy. Cellular senescence is a state of …
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CD8+ lymphocyte and progenitor cell mobilization during acute psychological stress and betaadrenergic stimulation
… mobilization of CD8+ T lymphocytes (CD8TLs) and progenitor cell (PC) populations. Chapter 2 demonstrated that CD8TL stress- and \(\beta\)AR- sensitivity increases in parallel with greater effector functions and cell differentiation. As Cytomegalovirus (CMV) infection influences CD8TL …
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The Role of Igf-1 and Il-4 in Myeloid Progenitor Cell Survival
The development of myeloid progenitor cells requires paracrine growth factors to mediate the proliferation, differentiation and survival of these cells. In this thesis, we demonstrate that IGF-I and IL-4, a cytokine produced by activated T-lymphocytes, enhance the survival of CSF-stimulated …
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Exploring the heterogeneity of the hematopoietic stem and progenitor cell pool in cord blood
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for a wide range of malignant and hereditary disorders. It is yet the only clinically established stem cell treatment. Hematopoietic stem and progenitor cells (HSPC) can be harvest-ed from bone marrow (BM), stimulated peripheral …
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CD133 Antibody Conjugation to Decellularized Human Heart Valves For Circulating Endothelial Progenitor Cell Capture
… and calcification. To avoid this degeneration, decellularized heart valves with functionalized surfaces capable of rapid in vivo endothelialization have been developed. The aim of this study is to examine the capacity of CD133 antibody-conjugated valve tissue to capture circulating endothelial …
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The role of thrombopoietin in promoting yolk sac hematopoietic progenitor cell growth and differentiation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Protective effect of JAK3 inhibition on growth factor deprivation induced neural progenitor cell death
… system. The number of embryonic neuroepithelial cells (NECs) is regulated by programmed cell death when NECs are substantially proliferated by growth factors(GFs). The extrinsic factors such as epidermal growth factor (EGF), basic fibroblast growth factor(bFGF), as well as intrinsic protein …
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Investigating the role of geometry, mechanics, and microenvironmental cues on liver progenitor cell differentiation
… of signals in the microenvironment that direct cells and tissue fates. This work focuses on developing and using such systems to investigate how mechanical characteristics impact liver progenitor cell differentiation. In this dissertation, I will introduce and review relevant concepts of …
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